GHB - Revision history

Toasterlizard: Reverted edits by Dumbdumb123 (talk) to last revision by Sleep

2018-10-09T22:09:33Z

Reverted edits by Dumbdumb123 (talk) to last revision by Sleep

← Older revision		Revision as of 17:09, 9 October 2018
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	== Effects ==		== Effects ==

	~~Goodbye moonmen~~		=== Positive ===
			*Relaxation
			*Increased sociability
			*Positive mood changes
			*Euphoria
			*Empathogenic
			*Enhanced sensuality

	~~Goodbye moonmen~~		=== Neutral ===
			*Dizziness

	== Negative ==		== Negative ==
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	*Amnesia		*Amnesia

	~~Goodbye moonmen~~		=== After effects ===

			* Hangover (usually only occurs from high doses)
			* [[#Dopamine Rebound]]


	== Harm Reduction ==		== Harm Reduction ==
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	If taken orally, GABA itself does not effectively cross the blood-brain-barrier.		If taken orally, GABA itself does not effectively cross the blood-brain-barrier.

	~~Goodbye moonmen~~		=== Dopamine Rebound ===

			GHB will reduce dopamine levels in high amounts, but increase dopamine levels in the brain in low amounts<ref>https://www.ncbi.nlm.nih.gov/pubmed/1847191</ref>. This leads to what is known as dopamine rebound among users. Users can experience strong wakefullness about 4 hours after the last dose was consumed. This is often strong enough to wake the user up from sleep, and may be accompanied by a strong redose compulsion. The longer and higher the dose of GHB used, the more pronounced the effect may become.

	~~Goodbye moonmen~~		=== Production ===
			Production of GHB consists simply of mixing "lactone" (short for gamma butyrlactone) and lye (sodium hydroxide) in the proper amounts. It can also be converted from GBL.

	== Legal status ==		== Legal status ==

Dumbdumb123: Goodbye moonmen

2018-10-09T21:56:34Z

Goodbye moonmen

← Older revision		Revision as of 16:56, 9 October 2018
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	Goodbye moonmen		Goodbye moonmen

	~~=== Production ===~~		Goodbye moonmen
	~~Production of GHB consists simply of mixing "lactone" (short for gamma butyrlactone) and lye (sodium hydroxide) in the proper amounts. It can also be converted from GBL.~~

	== Legal status ==		== Legal status ==

Dumbdumb123: Goodbye moonmen

2018-10-09T21:56:02Z

Goodbye moonmen

← Older revision		Revision as of 16:56, 9 October 2018
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	If taken orally, GABA itself does not effectively cross the blood-brain-barrier.		If taken orally, GABA itself does not effectively cross the blood-brain-barrier.

	~~=== Dopamine Rebound ===~~		Goodbye moonmen

	GHB will reduce dopamine levels in high amounts, but increase dopamine levels in the brain in low amounts<ref>https://www.ncbi.nlm.nih.gov/pubmed/1847191</ref>. This leads to what is known as dopamine rebound among users. Users can experience strong wakefullness about 4 hours after the last dose was consumed. This is often strong enough to wake the user up from sleep, and may be accompanied by a strong redose compulsion. The longer and higher the dose of GHB used, the more pronounced the effect may become.

	=== Production ===		=== Production ===

Dumbdumb123: Goodbye moonmen

2018-10-09T21:55:40Z

Goodbye moonmen

← Older revision		Revision as of 16:55, 9 October 2018
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	*Amnesia		*Amnesia

	~~=== After effects ===~~		Goodbye moonmen

	* Hangover (usually only occurs from high doses)
	* [[#Dopamine Rebound]]


	== Harm Reduction ==		== Harm Reduction ==

Dumbdumb123: Goodbye moonmen

2018-10-09T21:55:28Z

Goodbye moonmen

← Older revision		Revision as of 16:55, 9 October 2018
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	Goodbye moonmen		Goodbye moonmen

	~~=== Neutral ===~~		Goodbye moonmen
	*Dizziness

	== Negative ==		== Negative ==

Dumbdumb123: Goodbye moonmen

2018-10-09T21:55:15Z

Goodbye moonmen

← Older revision		Revision as of 16:55, 9 October 2018
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	== Effects ==		== Effects ==

	~~=== Positive ===~~		Goodbye moonmen
	*Relaxation
	*Increased sociability
	*Positive mood changes
	*Euphoria
	*Empathogenic
	*Enhanced sensuality

	=== Neutral ===		=== Neutral ===

Sleep at 21:14, 28 February 2017

2017-02-28T21:14:59Z

← Older revision		Revision as of 16:14, 28 February 2017
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	== Dosage ==		== Dosage ==

	GBL dose: 1ml GBL is equal to 1.6g GHB		GBL dose: 1ml GBL is equal to 1.6ml GHB

	{\| class="wikitable"		{\| class="wikitable"

GrimReaper at 10:38, 10 March 2015

2015-03-10T10:38:44Z

← Older revision		Revision as of 05:38, 10 March 2015
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	[[File:GHB.jpg\|right]]		[[File:GHB.jpg\|right]]

	GHB (Gamma-Hydroxybutyric Acid) is a CNS depressant used as intoxicant. It is a naturally occurring substance found in the human central nervous system, as well as in wine, beef, small citrus fruits, and in small amounts in almost all animals. GHB has been used in a medical setting as a general anaesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcohol withdrawal, and to improve athletic performance.		'''GHB''' (Gamma-Hydroxybutyric Acid) is a CNS depressant used as intoxicant. It is a naturally occurring substance found in the human central nervous system, as well as in wine, beef, small citrus fruits, and in small amounts in almost all animals. GHB has been used in a medical setting as a general anaesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcohol withdrawal, and to improve athletic performance.

	== History ==		== History ==
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	GHB (Xyrem) was approved by the FDA in 2002 for use in the treatment of narcolepsy/Cataplexy.		GHB (Xyrem) was approved by the FDA in 2002 for use in the treatment of narcolepsy/Cataplexy.

	= Dosage =		== Dosage ==

	GBL dose: 1ml GBL is equal to 1.6g GHB		GBL dose: 1ml GBL is equal to 1.6g GHB
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	\|}		\|}

	= Duration =		== Duration ==

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	= Effects =		== Effects ==

	== Positive ==		=== Positive ===
	*Relaxation		*Relaxation
	*Increased sociability		*Increased sociability
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	*Enhanced sensuality		*Enhanced sensuality

	== Neutral ==		=== Neutral ===
	*Dizziness		*Dizziness

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	*Amnesia		*Amnesia

	== After effects ==		=== After effects ===

	* Hangover (usually only occurs from high doses)		* Hangover (usually only occurs from high doses)
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	= Harm Reduction =		== Harm Reduction ==
	* The dosage curve of GHB is very steep, recreational doses being very close to doses which will cause a period of unrousable sleep, which are again relatively close to doses which may cause coma or death through respiratory depression.		* The dosage curve of GHB is very steep, recreational doses being very close to doses which will cause a period of unrousable sleep, which are again relatively close to doses which may cause coma or death through respiratory depression.
	*The only way to know the concentration of liquid GHB is to know and trust information provided by the source. Users should be extremely careful about GHB dosages as even small overdoses can result in temporarily unrousable sleep.		*The only way to know the concentration of liquid GHB is to know and trust information provided by the source. Users should be extremely careful about GHB dosages as even small overdoses can result in temporarily unrousable sleep.
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	* High addiction potential		* High addiction potential

	= Chemistry and Pharmacology =		== Chemistry and Pharmacology ==
	GHB has at least two distinct binding sites in the central nervous system. GHB is an agonist at the newly characterized GHB receptor, which is excitatory, and it is a weak agonist at the GABA-B receptor, which is inhibitory. GHB is a naturally occurring substance that acts in a similar fashion to some neurotransmitters in the mammalian brain. GHB is probably synthesized from GABA in GABAergic neurons, and released when the neurons fire.		GHB has at least two distinct binding sites in the central nervous system. GHB is an agonist at the newly characterized GHB receptor, which is excitatory, and it is a weak agonist at the GABA-B receptor, which is inhibitory. GHB is a naturally occurring substance that acts in a similar fashion to some neurotransmitters in the mammalian brain. GHB is probably synthesized from GABA in GABAergic neurons, and released when the neurons fire.

	If taken orally, GABA itself does not effectively cross the blood-brain-barrier.		If taken orally, GABA itself does not effectively cross the blood-brain-barrier.

	== Dopamine Rebound ==		=== Dopamine Rebound ===

	GHB will reduce dopamine levels in high amounts, but increase dopamine levels in the brain in low amounts<ref>https://www.ncbi.nlm.nih.gov/pubmed/1847191</ref>. This leads to what is known as dopamine rebound among users. Users can experience strong wakefullness about 4 hours after the last dose was consumed. This is often strong enough to wake the user up from sleep, and may be accompanied by a strong redose compulsion. The longer and higher the dose of GHB used, the more pronounced the effect may become.		GHB will reduce dopamine levels in high amounts, but increase dopamine levels in the brain in low amounts<ref>https://www.ncbi.nlm.nih.gov/pubmed/1847191</ref>. This leads to what is known as dopamine rebound among users. Users can experience strong wakefullness about 4 hours after the last dose was consumed. This is often strong enough to wake the user up from sleep, and may be accompanied by a strong redose compulsion. The longer and higher the dose of GHB used, the more pronounced the effect may become.

	== Production ==		=== Production ===
	Production of GHB consists simply of mixing "lactone" (short for gamma butyrlactone) and lye (sodium hydroxide) in the proper amounts. It can also be converted from GBL.		Production of GHB consists simply of mixing "lactone" (short for gamma butyrlactone) and lye (sodium hydroxide) in the proper amounts. It can also be converted from GBL.

	= Legal status =		== Legal status ==

	GHB is illegal in most parts of the world, GBL is legal in parts of Europe.		GHB is illegal in most parts of the world, GBL is legal in parts of Europe.

	= Links =		== Links ==

	[http://en.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid Wikipedia]		[http://en.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid Wikipedia]
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	[https://www.erowid.org/chemicals/ghb/ghb.shtml Erowid]		[https://www.erowid.org/chemicals/ghb/ghb.shtml Erowid]

	= References =		== References ==

	<references />		<references />

Roi at 19:30, 1 August 2014

2014-08-01T19:30:31Z

← Older revision		Revision as of 14:30, 1 August 2014
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	GHB was widely used in France, Italy, and other European countries for several decades as a sleeping agent and an anesthetic in childbirth, but problems with its abuse potential and development of newer drugs have led to a decrease in the medical use in recent times.		GHB was widely used in France, Italy, and other European countries for several decades as a sleeping agent and an anesthetic in childbirth, but problems with its abuse potential and development of newer drugs have led to a decrease in the medical use in recent times.

	In the 1980's It was marketed for a short time as a fat burner and muscle developer. However, in 1990, based off many reports of GHB-linked illness, ~~The~~ FDA declared GHB unsafe, and ordered it to be removed from stores shelves. Following this, many users switched to GBL and 1 4-butanediol.		In the 1980's It was marketed for a short time as a fat burner and muscle developer. However, in 1990, based off many reports of GHB-linked illness, the FDA declared GHB unsafe, and ordered it to be removed from stores shelves. Following this, many users switched to GBL and 1 4-butanediol.

	GHB (Xyrem) was approved by the FDA in 2002 for use in the treatment of narcolepsy/Cataplexy.		GHB (Xyrem) was approved by the FDA in 2002 for use in the treatment of narcolepsy/Cataplexy.

Sleep: /* History */

2014-08-01T19:28:15Z

History

← Older revision		Revision as of 14:28, 1 August 2014
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	Synthesis of this chemical was first reported in 1874 by Alexander Zaytsev. But the first major research in humans was conducted in the early 1960's by Dr. Henri Laborit to use in studying the neurotransmitter GABA.		Synthesis of this chemical was first reported in 1874 by Alexander Zaytsev. But the first major research in humans was conducted in the early 1960's by Dr. Henri Laborit to use in studying the neurotransmitter GABA.

	Throughout most of the 1960's it was a popular anesthetic, was abandoned by doctors following discoveries of its poor analgesic effects. In the 1970's was recommended for the treatment of narcolepsy, though the euphoric side of GHB made that unfavourable.		Throughout most of the 1960's it was a popular anesthetic, then was abandoned by doctors, following discoveries of its poor analgesic effects. In the 1970's was recommended for the treatment of narcolepsy, though the euphoric side of GHB made that unfavourable.

	GHB was widely used in France, Italy, and other European countries for several decades as a sleeping agent and an anesthetic in childbirth, but problems with its abuse potential and development of newer drugs have led to a decrease in the medical use in recent times.		GHB was widely used in France, Italy, and other European countries for several decades as a sleeping agent and an anesthetic in childbirth, but problems with its abuse potential and development of newer drugs have led to a decrease in the medical use in recent times.