Fentanyl - Revision history

Nndmt: /* Negative */ british english edit

2015-04-02T17:45:07Z

Negative: british english edit

← Older revision		Revision as of 12:45, 2 April 2015
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	*Respiratory depression		*Respiratory depression
	*~~Diarrhea~~		*Diarrhoea
	*Nausea		*Nausea
	*Constipation		*Constipation

Nndmt: /* Negative */ capitalization

2015-04-02T17:43:56Z

Negative: capitalization

← Older revision		Revision as of 12:43, 2 April 2015
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	*Dry Mouth		*Dry Mouth
	*Somnolence		*Somnolence
	*~~confusion~~		*Confusion
	*~~weakness~~		*Weakness
	*Sweating		*Sweating
	*~~headache~~		*Headache
	*Fatigue		*Fatigue
	*Dizziness		*Dizziness

GrimReaper at 10:37, 10 March 2015

2015-03-10T10:37:33Z

← Older revision		Revision as of 05:37, 10 March 2015
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	Fentanyl is a synthetic opiate analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors and is historically used to treat breakthrough pain. Fentanyl is approximately 100 times more potent than morphine, and is commonly used as a patch. The patches work by releasing fentanyl into body fats, which then slowly release the drug into the bloodstream over 48 to 72 hours, allowing for long-lasting relief from pain.		'''Fentanyl''' is a synthetic opiate analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors and is historically used to treat breakthrough pain. Fentanyl is approximately 100 times more potent than morphine, and is commonly used as a patch. The patches work by releasing fentanyl into body fats, which then slowly release the drug into the bloodstream over 48 to 72 hours, allowing for long-lasting relief from pain.

	=== History ===		== History ==

	Fentanyl was first synthesized by Paul Janssen in 1960. Fentanyl was introduced in patch form in the mid 1990s, shortly followed by lollipop form. As of 2012 fentanyl was the most widely used synthetic opioid in clinical practice.		Fentanyl was first synthesized by Paul Janssen in 1960. Fentanyl was introduced in patch form in the mid 1990s, shortly followed by lollipop form. As of 2012 fentanyl was the most widely used synthetic opioid in clinical practice.
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	== Legal ==		== Legal status==
	In most countries, fentanyl is illegal to sell without a license and illegal to buy or possess without a license or prescription.		In most countries, fentanyl is illegal to sell without a license and illegal to buy or possess without a license or prescription.

	~~===~~ Europe ~~===~~		*Europe: http://europa.eu/legislation_summaries/customs/l33215_en.htm
			*USA: Regulated as a schedule II opiate.
	~~See~~: http://europa.eu/legislation_summaries/customs/l33215_en.htm		*Canada: Regulated as schedule I.
			*Australia: Fentanyl is a border controlled substance under Criminal Code Act 9.1.314 and is additionally controlled by several states and territories.
	~~=== America ===~~
	Regulated as a schedule II opiate.

	~~===~~ Canada ~~===~~
	Regulated as schedule I.

	~~===~~ Australia ~~===~~
	Fentanyl is a border controlled substance under Criminal Code Act 9.1.314 and is additionally controlled by several states and territories.

	[[Category:Drugs]]		[[Category:Drugs]]

Roi at 06:17, 21 July 2014

2014-07-21T06:17:33Z

← Older revision		Revision as of 01:17, 21 July 2014
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	~~== General Information ==~~

	~~=== Introduction ===~~

	Fentanyl is a synthetic opiate analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors and is historically used to treat breakthrough pain. Fentanyl is approximately 100 times more potent than morphine, and is commonly used as a patch. The patches work by releasing fentanyl into body fats, which then slowly release the drug into the bloodstream over 48 to 72 hours, allowing for long-lasting relief from pain.		Fentanyl is a synthetic opiate analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors and is historically used to treat breakthrough pain. Fentanyl is approximately 100 times more potent than morphine, and is commonly used as a patch. The patches work by releasing fentanyl into body fats, which then slowly release the drug into the bloodstream over 48 to 72 hours, allowing for long-lasting relief from pain.

CustaiCo: Categorization

2014-07-21T06:16:32Z

Categorization

← Older revision		Revision as of 01:16, 21 July 2014
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	=== Australia ===		=== Australia ===
	Fentanyl is a border controlled substance under Criminal Code Act 9.1.314 and is additionally controlled by several states and territories.		Fentanyl is a border controlled substance under Criminal Code Act 9.1.314 and is additionally controlled by several states and territories.

			[[Category:Drugs]]

			[[Category:Opioid]]

			[[Category:Depressant]]

Anonymous: /* Images */

2013-10-20T22:36:07Z

Images

← Older revision		Revision as of 17:36, 20 October 2013
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	[[file:fpatch.gif\|thumb\|left\|packaging for the 100ug/hr Mylan brand fentanyl patch]]		[[file:fpatch.gif\|thumb\|left\|packaging for the 100ug/hr Mylan brand fentanyl patch]]
	[[file:Mylan.jpg\|thumb\|left\|400x400\|a 75ug/hr Mylan patch applied to the skin]]		[[file:Mylan.jpg\|thumb\|left\|400x400\|a 75ug/hr Mylan patch applied to the skin]]
			<br clear="all"/>

	== Legal ==		== Legal ==

Anonymous: /* Images */ +images

2013-10-20T22:35:32Z

Images: +images

← Older revision		Revision as of 17:35, 20 October 2013
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	== Images ==		== Images ==
	[[File:fent.jpg]]		[[File:fent.jpg\|thumb\|left\|various commercial preparations for parenteral administration]]
			[[file:fpatch.gif\|thumb\|left\|packaging for the 100ug/hr Mylan brand fentanyl patch]]
			[[file:Mylan.jpg\|thumb\|left\|400x400\|a 75ug/hr Mylan patch applied to the skin]]

	== Legal ==		== Legal ==

Anonymous: /* Buccal: Lollipop Lozenge */ removed due to inaccurate data

2013-10-20T15:56:49Z

Buccal: Lollipop Lozenge: removed due to inaccurate data

← Older revision		Revision as of 10:56, 20 October 2013
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	The patch may be taken orally (sublingually) by sectioning into doses (such as 1/10th of a 10mg patch being 1mg delivered), but it is not recommended, and requires a solvent such as overproof ethanol for sufficient absorption.		The patch may be taken orally (sublingually) by sectioning into doses (such as 1/10th of a 10mg patch being 1mg delivered), but it is not recommended, and requires a solvent such as overproof ethanol for sufficient absorption.

	~~=== Buccal: Lollipop Lozenge ===~~

	~~Oral Bioavailability: 33%-50%~~

	~~Comeup time 8-12 hours~~

	~~Duration: 1-2 hours~~

	~~Typical dose: 400 μg~~

	~~High dose: 1600 μg~~

	~~Available in dosages from 200 μg to 1600μg~~

	=== Insufflated ===		=== Insufflated ===

Anonymous: /* After effects */

2013-10-20T15:49:14Z

After effects

← Older revision		Revision as of 10:49, 20 October 2013
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	=== After effects ===		=== After effects ===

	* Risk of post-acute withdrawal effects, including depression, anxiety disorder, psychosis, or even suicidal ideation in extreme cases		* Risk of post-acute withdrawal effects, diarrhea including depression, anxiety disorder, psychosis, or even suicidal ideation in extreme cases

	== Harm Reduction ==		== Harm Reduction ==

Anonymous: /* Injected */ clarify "powder"

2013-10-20T15:48:40Z

Injected: clarify "powder"

← Older revision		Revision as of 10:48, 20 October 2013
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	=== Injected ===		=== Injected ===
	Fentanyl ~~powder may be injected, but it~~ is not ~~recommended~~.		Fentanyl is most commonly prepared in a saline solution with lactose or inositol as a buffering agent and either sold as heroin or as fentanyl itself. Fentanyl is not commonly available by itself as a powder and has low potential for abuse due to the low margin of safety with microgram-scale dosages.

	== Effects ==		== Effects ==