Etizolam - Revision history

Anonymous: /* Doses */

2020-12-27T22:53:34Z

Doses

← Older revision		Revision as of 17:53, 27 December 2020
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	\| Common \|\|1-2mg		\| Common \|\|1-2mg
	\|-		\|-
	\| Strong \|\|2-~~5mg~~		\| Strong \|\|2-4mg
	\|-		\|-
	\|Heavy \|\|~~5mg~~+		\|Heavy \|\|4mg+
	\|}		\|}

GrimReaper at 10:29, 10 March 2015

2015-03-10T10:29:39Z

← Older revision		Revision as of 05:29, 10 March 2015
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	[[File:Etizolam.jpg\|thumb\|300px\|Sealed vial of etizolam dissolved in propylene glycol.]]		[[File:Etizolam.jpg\|thumb\|300px\|Sealed vial of etizolam dissolved in propylene glycol.]]

	Etizolam is a research chemical analogue of the [[benzodiazepines\|benzodiazepine]] class of drugs - the benzene ring being replaced by a thiophene ring, making it a thienodiazepine. The drug largely shares the effect profile of benzodiazepine drugs (being both hypnotic and anxiolytic), however studies have shown some major differences between etizolam and the more traditional benzos used for treatments; it suffers much less from a rapid build-up of tolerance, and also has a larger range of observed side-effects with abuse.		'''Etizolam''' is a research chemical analogue of the [[benzodiazepines\|benzodiazepine]] class of drugs - the benzene ring being replaced by a thiophene ring, making it a thienodiazepine. The drug largely shares the effect profile of benzodiazepine drugs (being both hypnotic and anxiolytic), however studies have shown some major differences between etizolam and the more traditional benzos used for treatments; it suffers much less from a rapid build-up of tolerance, and also has a larger range of observed side-effects with abuse.

	= History =		== History ==

	The availability of Etizolam in the more general research chemical scene began around 2011, and attention has only increased since. Its prevalence is probably due to both the low cost of the drug (with 500-1000 standard doses costing around £100, and is available in bulk powder form for even less), and the highly addictive nature it shares with benzodiazepines.		The availability of Etizolam in the more general research chemical scene began around 2011, and attention has only increased since. Its prevalence is probably due to both the low cost of the drug (with 500-1000 standard doses costing around £100, and is available in bulk powder form for even less), and the highly addictive nature it shares with benzodiazepines.
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	Though relatively new to the recreational research chemical scene, etizolam differs from most other research chemicals in that it is actually approved and actively prescribed as a medical treatment for anxiety in many countries around the world (such as India) under brand names such as Etilaam and Etizest. Its origins as a medical drug are actually very unclear, though medical papers citing its use in the treatment of anxiety are recorded as early as the 90s.		Though relatively new to the recreational research chemical scene, etizolam differs from most other research chemicals in that it is actually approved and actively prescribed as a medical treatment for anxiety in many countries around the world (such as India) under brand names such as Etilaam and Etizest. Its origins as a medical drug are actually very unclear, though medical papers citing its use in the treatment of anxiety are recorded as early as the 90s.

	= Doses =		== Doses ==

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	= Duration =		== Duration ==

	Note: Duration can be significantly longer with higher doses.		Note: Duration can be significantly longer with higher doses.
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	\|}		\|}

	= Effects =		== Effects ==

	== Positive ==		=== Positive ===

	* Anti-Anxiety		* Anti-Anxiety
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	* A Sense of Well Being		* A Sense of Well Being

	== Neutral ==		=== Neutral ===

	* Appetite fluctuation		* Appetite fluctuation
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	* Drowsiness		* Drowsiness

	== Negative ==		=== Negative ===

	* Memory loss		* Memory loss
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	* Emotional and social dissociation or derealization (long term)		* Emotional and social dissociation or derealization (long term)

	== Long Term Effects ==		=== Long Term Effects ===

	* The effects of long-term Etizolam, as with benzodiazepine use include drug dependence as well as the possibility of adverse effects on cognitive function, physical health, and mental health.		* The effects of long-term Etizolam, as with benzodiazepine use include drug dependence as well as the possibility of adverse effects on cognitive function, physical health, and mental health.
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	* In very rare cases, Etizolam has been responsible for skin lesions in abusers.		* In very rare cases, Etizolam has been responsible for skin lesions in abusers.

	= Harm Reduction =		== Harm Reduction ==

	* When on high doses of depressants, users are likely to black out and potentially hurt themselves through misadventure. If you are taking a hypnotic dose of Etizolam, it is best to confine yourself to your bed.		* When on high doses of depressants, users are likely to black out and potentially hurt themselves through misadventure. If you are taking a hypnotic dose of Etizolam, it is best to confine yourself to your bed.
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	* Some users report Etizolam as given to compulsive redosing, especially when a user is 'blacked out'. To avoid this, keep doses low and be wary of reduced inhibitions while under the influence.		* Some users report Etizolam as given to compulsive redosing, especially when a user is 'blacked out'. To avoid this, keep doses low and be wary of reduced inhibitions while under the influence.

	==Interactions==		=== Interactions ===

	As with other depressants, Etizolam should not be combined with any other CNS depressants (such as [[alcohol]]), at the risk of respiratory depression, which can lead to death.		As with other depressants, Etizolam should not be combined with any other CNS depressants (such as [[alcohol]]), at the risk of respiratory depression, which can lead to death.
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	See the [[Drug combinations]] chart for more information.		See the [[Drug combinations]] chart for more information.

	= Chemistry and Pharmacology =		== Chemistry and Pharmacology ==

	Etizolam is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects. In addition, etizolam, unlike most other benzodiazepines, has prolactogenic effects, leading to an increase in blood levels of prolactin, which is a protein that in humans is best known for its role in enabling female mammals to produce milk.		Etizolam is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects. In addition, etizolam, unlike most other benzodiazepines, has prolactogenic effects, leading to an increase in blood levels of prolactin, which is a protein that in humans is best known for its role in enabling female mammals to produce milk.
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	The LD50 of Etizolam is currently unknown.		The LD50 of Etizolam is currently unknown.

	= ~~Legal status =~~		== Images ==

	~~==USA==~~

	~~Etizolam is not controlled in the USA. However, it is a Schedule I drug in Arkansas and Mississippi.~~

	~~==UK==~~

	~~Not controlled as of October 2014.~~

	==~~Germany==~~

	~~Controlled since 2013.~~

	~~=Images~~=
	<gallery mode="packed-hover" heights="200px">		<gallery mode="packed-hover" heights="200px">
	Image:Etizolam.jpg\|''Etizolam solution''		Image:Etizolam.jpg\|''Etizolam solution''
	Image:etizolam2.jpg\|''Etizolam tablets''		Image:etizolam2.jpg\|''Etizolam tablets''
	</gallery>		</gallery>

			== Legal status ==
			* USA: Not controlled in the USA. However, it is a Schedule I drug in Arkansas and Mississippi.
			* UK: Not controlled as of October 2014.
			* Germany: Controlled since 2013.

	= Links =		== Links ==

	* [http://tripsit.me/history-of-etizolam History of Etizolam]		* [http://tripsit.me/history-of-etizolam History of Etizolam]

Sleep at 20:27, 23 December 2014

2014-12-23T20:27:08Z

← Older revision		Revision as of 15:27, 23 December 2014
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	[[Category:Drugs]]		[[Category:Drugs]]
			[[Category:Research Chemical]]

Sleep at 11:11, 22 December 2014

2014-12-22T11:11:38Z

← Older revision		Revision as of 06:11, 22 December 2014
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	[[File:Etizolam.jpg\|thumb\|300px\|Sealed vial of etizolam ~~solved~~ in propylene glycol.]]		[[File:Etizolam.jpg\|thumb\|300px\|Sealed vial of etizolam dissolved in propylene glycol.]]

	Etizolam is a research chemical analogue of the [[benzodiazepines\|benzodiazepine]] class of drugs - the benzene ring being replaced by a thiophene ring, making it a thienodiazepine. The drug largely shares the effect profile of benzodiazepine drugs (being both hypnotic and anxiolytic), however studies have shown some major differences between etizolam and the more traditional benzos used for treatments; it suffers much less from a rapid build-up of tolerance, and also has a larger range of observed side-effects with abuse.		Etizolam is a research chemical analogue of the [[benzodiazepines\|benzodiazepine]] class of drugs - the benzene ring being replaced by a thiophene ring, making it a thienodiazepine. The drug largely shares the effect profile of benzodiazepine drugs (being both hypnotic and anxiolytic), however studies have shown some major differences between etizolam and the more traditional benzos used for treatments; it suffers much less from a rapid build-up of tolerance, and also has a larger range of observed side-effects with abuse.

Reality at 15:44, 14 November 2014

2014-11-14T15:44:33Z

← Older revision		Revision as of 10:44, 14 November 2014
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	[[File:Etizolam.jpg\|thumb\|300px\|Sealed vial of etizolam solved in propylene glycol.]]		[[File:Etizolam.jpg\|thumb\|300px\|Sealed vial of etizolam solved in propylene glycol.]]

	Etizolam is a research chemical analogue of the [[benzodiazepines\|benzodiazepine]] class of drugs - the benzene ring being replaced by a thiophene ring, making it a thienodiazepine. The drug largely shares the effect profile of benzodiazepine drugs (being both hypnotic and anxiolytic), however studies have shown some major differences between etizolam and the more traditional benzos used for treatments; it suffers much less from ~~the~~ build-up of tolerance, and also has a larger range of observed side-effects with abuse.		Etizolam is a research chemical analogue of the [[benzodiazepines\|benzodiazepine]] class of drugs - the benzene ring being replaced by a thiophene ring, making it a thienodiazepine. The drug largely shares the effect profile of benzodiazepine drugs (being both hypnotic and anxiolytic), however studies have shown some major differences between etizolam and the more traditional benzos used for treatments; it suffers much less from a rapid build-up of tolerance, and also has a larger range of observed side-effects with abuse.

	= History =		= History =

Sevenforall: /* Chemistry and Pharmacology */

2014-10-15T14:30:15Z

Chemistry and Pharmacology

← Older revision		Revision as of 09:30, 15 October 2014
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	= Chemistry and Pharmacology =		= Chemistry and Pharmacology =

	Etizolam is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects. In addition, etizolam, unlike most other benzodiazepines, has prolactogenic effects, leading to an increase in blood levels of prolactin, which is a protein that in humans is best known for its role in enabling female mammals to produce milk~~. Etizolam abuse can also cause lactation in males~~.		Etizolam is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects. In addition, etizolam, unlike most other benzodiazepines, has prolactogenic effects, leading to an increase in blood levels of prolactin, which is a protein that in humans is best known for its role in enabling female mammals to produce milk.

	During a controlled clinical trial that compared the effectiveness of etizolam and several benzodiazepines for the treatment of generalized anxiety disorder, it was found that etizolam became more effective over time, implying a type of reverse tolerance.		During a controlled clinical trial that compared the effectiveness of etizolam and several benzodiazepines for the treatment of generalized anxiety disorder, it was found that etizolam became more effective over time, implying a type of reverse tolerance.

Sevenforall: /* Chemistry and Pharmacology */

2014-10-15T13:54:52Z

Chemistry and Pharmacology

← Older revision		Revision as of 08:54, 15 October 2014
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	= Chemistry and Pharmacology =		= Chemistry and Pharmacology =

	Etizolam is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects.		Etizolam is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam acts as a full agonist at the benzodiazepine receptor to produce its range of therapeutic and adverse effects. In addition, etizolam, unlike most other benzodiazepines, has prolactogenic effects, leading to an increase in blood levels of prolactin, which is a protein that in humans is best known for its role in enabling female mammals to produce milk. Etizolam abuse can also cause lactation in males.

	In addition, etizolam, unlike most other benzodiazepines, has prolactogenic effects, leading to an increase in blood levels of prolactin, which is a protein that in humans is best known for its role in enabling female mammals to produce milk. Etizolam abuse can also cause lactation in males.

	During a controlled clinical trial that compared the effectiveness of etizolam and several benzodiazepines for the treatment of generalized anxiety disorder, it was found that etizolam became more effective over time, implying a type of reverse tolerance.		During a controlled clinical trial that compared the effectiveness of etizolam and several benzodiazepines for the treatment of generalized anxiety disorder, it was found that etizolam became more effective over time, implying a type of reverse tolerance.

Sevenforall: /* USA */

2014-10-15T13:54:31Z

USA

← Older revision		Revision as of 08:54, 15 October 2014
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	==USA==		==USA==

	Etizolam is not controlled in the USA, ~~however~~ it is a Schedule I drug in Arkansas and Mississippi.		Etizolam is not controlled in the USA. However, it is a Schedule I drug in Arkansas and Mississippi.

	==UK==		==UK==

Sevenforall: /* Chemistry and Pharmacology */

2014-10-15T13:50:14Z

Chemistry and Pharmacology

← Older revision		Revision as of 08:50, 15 October 2014
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	In addition, etizolam, unlike most other benzodiazepines, has prolactogenic effects, leading to an increase in blood levels of prolactin, which is a protein that in humans is best known for its role in enabling female mammals to produce milk. Etizolam abuse can also cause lactation in males.		In addition, etizolam, unlike most other benzodiazepines, has prolactogenic effects, leading to an increase in blood levels of prolactin, which is a protein that in humans is best known for its role in enabling female mammals to produce milk. Etizolam abuse can also cause lactation in males.

	During a controlled clinical trial that compared the effectiveness of etizolam and several benzodiazepines for the treatment of generalized anxiety disorder, it was found that etizolam became more effective ~~from 2 weeks to 4 weeks~~, ~~which implies~~ a type of reverse tolerance.		During a controlled clinical trial that compared the effectiveness of etizolam and several benzodiazepines for the treatment of generalized anxiety disorder, it was found that etizolam became more effective over time, implying a type of reverse tolerance.

	The LD50 of Etizolam is currently unknown.		The LD50 of Etizolam is currently unknown.

Sevenforall at 13:49, 15 October 2014

2014-10-15T13:49:25Z

← Older revision		Revision as of 08:49, 15 October 2014
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	* There are a number of side-effects associated with addiction to benzodiazepines such as depression and flu-like symptoms, though occurring in only a small amount of people.		* There are a number of side-effects associated with addiction to benzodiazepines such as depression and flu-like symptoms, though occurring in only a small amount of people.

	~~= Harm Reduction =~~		* In some users, particular with abuse Etizolam has been shown to cause blepharospasm.

	* ~~When on high doses of the drug~~, ~~users are likely to black out and potentially hurt themselves through misadventure. If you are taking a hypnotic dose, it is best to confine yourself to your bed~~.		* In very rare cases, Etizolam has been responsible for skin lesions in abusers.

	* Some users report Etizolam as given to compulsive redosing, especially when a user is 'blacked out.' To avoid this, keep doses low and take note of reduced inhibitons while under the influence.		= Harm Reduction =

	* ~~In some~~ users, ~~particular with abuse Etizolam has been shown~~ to ~~cause blepharospasm~~.		* When on high doses of depressants, users are likely to black out and potentially hurt themselves through misadventure. If you are taking a hypnotic dose of Etizolam, it is best to confine yourself to your bed.

	* ~~In very rare cases~~, ~~Etizolam has been responsible for skin lesions in abusers~~.		* Some users report Etizolam as given to compulsive redosing, especially when a user is 'blacked out'. To avoid this, keep doses low and be wary of reduced inhibitions while under the influence.

	==Interactions==		==Interactions==