Diphenhydramine - Revision history

Sleep at 01:46, 6 July 2016

2016-07-06T01:46:24Z

← Older revision		Revision as of 20:46, 5 July 2016
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	* If taking high doses, it is a very good idea to have a sober tripsitter or a friend with you		* If taking high doses, it is a very good idea to have a sober tripsitter or a friend with you

			* High doses have led to seizures.
	== Links ==		== Links ==

Lightning po: Revised harm reduction information regarding mixes with dxm and opiates.

2015-12-08T06:38:46Z

Revised harm reduction information regarding mixes with dxm and opiates.

← Older revision		Revision as of 01:38, 8 December 2015
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	* Many oral diphenhydramine preparations contain analgesics such as acetaminophen/paracetamol or aspirin, which can be toxic to the liver in high doses. Some adulterants, such as paracetamol, can be removed by [[Cold Water Extraction]].		* Many oral diphenhydramine preparations contain analgesics such as acetaminophen/paracetamol or aspirin, which can be toxic to the liver in high doses. Some adulterants, such as paracetamol, can be removed by [[Cold Water Extraction]].

	* Do not combine DPH with any other depressant drugs such as benzos, DXM, alcohol, or opiates		* Do not combine LARGE, recreational doses of DPH with any other depressant drugs such as benzos, DXM, alcohol, or opiates
			*However smaller doses (25mg-50mg) are totally safe to mix with dxm and opiates and cut down on the itching caused by them

	* DPH in high doses may induce delirium, making him or her unpredictable and possible dangerous, especially in public		* DPH in high doses may induce delirium, making him or her unpredictable and possible dangerous, especially in public

GrimReaper at 10:17, 10 March 2015

2015-03-10T10:17:13Z

← Older revision		Revision as of 05:17, 10 March 2015
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	[[File:Benadryl.jpg\|right]]		[[File:Benadryl.jpg\|right]]
	Diphenhydramine (DPH, also sold as Benadryl) is an antihistamine with anticholinergic and sedative effects. It is found in both OTC and prescription drugs used in the treatment of allergy-related symptoms, some cold and flu symptoms, insomnia, motion sickness and Parkinson's disease. It has also been researched for many other medicinal uses, including the treatment of OCD.		'''Diphenhydramine''' (DPH, also sold as Benadryl) is an antihistamine with anticholinergic and sedative effects. It is found in both OTC and prescription drugs used in the treatment of allergy-related symptoms, some cold and flu symptoms, insomnia, motion sickness and Parkinson's disease. It has also been researched for many other medicinal uses, including the treatment of OCD.

	It has also seen recreational use as a [[depressants\|depressant]] or [[deliriants\|deliriant]] drug, with high doses inducing vivid hallucinations which users are often unable to distinguish from reality. Most recreational users find the drug causes a negative experience, due to the profusely negative experience it tends to provide - along with the large amount of negative physical side-effects.		It has also seen recreational use as a [[depressants\|depressant]] or [[deliriants\|deliriant]] drug, with high doses inducing vivid hallucinations which users are often unable to distinguish from reality. Most recreational users find the drug causes a negative experience, due to the profusely negative experience it tends to provide - along with the large amount of negative physical side-effects.
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	In the 1980s, the drug became approved for over-the-counter use as a sleep-aid (due to its sedative effect) and antihistamine.		In the 1980s, the drug became approved for over-the-counter use as a sleep-aid (due to its sedative effect) and antihistamine.

	= Dosage =		== Dosage ==

	Overdoses of DPH may cause seizures, coma and ultimately an acute overdose of DPH can be fatal through cardiovascular collapse - though the threshold for this type of reaction is relatively unknown.		Overdoses of DPH may cause seizures, coma and ultimately an acute overdose of DPH can be fatal through cardiovascular collapse - though the threshold for this type of reaction is relatively unknown.
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	\|}		\|}

	= Duration =		== Duration ==

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	= Effects =		== Effects ==

	Though DPH causes hallucinations and distortions in the perception, which are often effects sought by the recreational users of [[psychedelics]], these effects are often negative in nature due to the [[deliriants\|deliriant]] nature of the chemical and experience.		Though DPH causes hallucinations and distortions in the perception, which are often effects sought by the recreational users of [[psychedelics]], these effects are often negative in nature due to the [[deliriants\|deliriant]] nature of the chemical and experience.

	== Positive ==		=== Positive ===
	* Increased awareness and appreciation of music		* Increased awareness and appreciation of music
	* Dream-like experiences		* Dream-like experiences
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	* Muscle relaxation		* Muscle relaxation

	== Neutral ==		=== Neutral ===

	* Visual distortions		* Visual distortions
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	* Sound distortions		* Sound distortions

	== Negative ==		=== Negative ===

	* Dry mouth		* Dry mouth
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	* Dysphoria		* Dysphoria

	= Chemistry and Pharmacology =		== Chemistry and Pharmacology ==
	[[File:DPH_molecule.png\|110px\|right]]		[[File:DPH_molecule.png\|110px\|right]]
	Chemical name: 2-(diphenylmethoxy)-N,N-dimethylethanamine		Chemical name: 2-(diphenylmethoxy)-N,N-dimethylethanamine
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	Diphenhydramine is an inverse agonist of the histamine H1 receptor. It is a member of the ethanolamine class of antihistaminergic agents. By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. Diphenhydramine also crosses the blood–brain barrier and antagonizes the H1 receptors centrally. Its effects on central H1receptors cause drowsiness.		Diphenhydramine is an inverse agonist of the histamine H1 receptor. It is a member of the ethanolamine class of antihistaminergic agents. By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. Diphenhydramine also crosses the blood–brain barrier and antagonizes the H1 receptors centrally. Its effects on central H1receptors cause drowsiness.

	= Harm Reduction =		== Harm Reduction ==

	* Many oral diphenhydramine preparations contain analgesics such as acetaminophen/paracetamol or aspirin, which can be toxic to the liver in high doses. Some adulterants, such as paracetamol, can be removed by [[Cold Water Extraction]].		* Many oral diphenhydramine preparations contain analgesics such as acetaminophen/paracetamol or aspirin, which can be toxic to the liver in high doses. Some adulterants, such as paracetamol, can be removed by [[Cold Water Extraction]].
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	* If taking high doses, it is a very good idea to have a sober tripsitter or a friend with you		* If taking high doses, it is a very good idea to have a sober tripsitter or a friend with you

	= Links =		== Links ==

	* [http://www.erowid.org/pharms/diphenhydramine/diphenhydramine.shtml Erowid]		* [http://www.erowid.org/pharms/diphenhydramine/diphenhydramine.shtml Erowid]

Trainwreck: /* Harm Reduction */

2014-07-17T16:35:34Z

Harm Reduction

← Older revision		Revision as of 11:35, 17 July 2014
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	* Many oral diphenhydramine preparations contain analgesics such as acetaminophen/paracetamol or aspirin, which can be toxic to the liver in high doses. Some adulterants, such as paracetamol, can be removed by [[Cold Water Extraction]].		* Many oral diphenhydramine preparations contain analgesics such as acetaminophen/paracetamol or aspirin, which can be toxic to the liver in high doses. Some adulterants, such as paracetamol, can be removed by [[Cold Water Extraction]].

	* Do not combine DPH with any other depressant drugs.		* Do not combine DPH with any other depressant drugs such as benzos, DXM, alcohol, or opiates

			* DPH in high doses may induce delirium, making him or her unpredictable and possible dangerous, especially in public

			* Never drive or operate heavy machinery under the influence

			* If taking high doses, it is a very good idea to have a sober tripsitter or a friend with you

	= Links =		= Links =

Reality at 14:16, 16 July 2014

2014-07-16T14:16:20Z

← Older revision		Revision as of 09:16, 16 July 2014
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	Overdoses of DPH may cause seizures, coma and ultimately an acute overdose of DPH can be fatal through cardiovascular collapse - though the threshold for this type of reaction is relatively unknown.		Overdoses of DPH may cause seizures, coma and ultimately an acute overdose of DPH can be fatal through cardiovascular collapse - though the threshold for this type of reaction is relatively unknown.

	~~== Oral ==~~

	DPH is primarily taken orally.		DPH is primarily taken orally.

	Therapeutic (insomnia): 50mg		{\| class="wikitable"
			\|+ Oral
	Light: 150-300mg		\|-
			\| Therapeutic (insomnia) \|\| 50mg
	Common: 250-500mg		\|-
			\| Light \|\| 150-300mg
	Strong: 450-700mg		\|-
			\| Common \|\| 250-500mg
	Heavy: 650-800mg+		\|-
			\| Strong \|\| 450-700mg
			\|-
			\| Heavy \|\| 650-800mg
			\|}

	= Duration =		= Duration =
	~~Onset: 60-120 minutes~~
	~~Duration: 6-8 hours~~

	After-effects: 24 hours		{\| class="wikitable"
			\|+ Oral
			\|-
			\| Onset \|\| 60-120 minutes
			\|-
			\| Total \|\| 6-8 hours
			\|-
			\| After-effects \|\| 24 hours
			\|}

	= Effects =		= Effects =


	Though DPH causes hallucinations and distortions in the perception, which are often effects sought by the recreational users of [[psychedelics]], these effects are often negative in nature due to the [[deliriants\|deliriant]] nature of the chemical and experience.		Though DPH causes hallucinations and distortions in the perception, which are often effects sought by the recreational users of [[psychedelics]], these effects are often negative in nature due to the [[deliriants\|deliriant]] nature of the chemical and experience.

GrimReaper at 17:12, 15 July 2014

2014-07-15T17:12:58Z

← Older revision		Revision as of 12:12, 15 July 2014
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			[[File:Benadryl.jpg\|right]]
	Diphenhydramine (DPH, also sold as Benadryl) is an antihistamine with anticholinergic and sedative effects. It is found in both OTC and prescription drugs used in the treatment of allergy-related symptoms, some cold and flu symptoms, insomnia, motion sickness and Parkinson's disease. It has also been researched for many other medicinal uses, including the treatment of OCD.		Diphenhydramine (DPH, also sold as Benadryl) is an antihistamine with anticholinergic and sedative effects. It is found in both OTC and prescription drugs used in the treatment of allergy-related symptoms, some cold and flu symptoms, insomnia, motion sickness and Parkinson's disease. It has also been researched for many other medicinal uses, including the treatment of OCD.

GrimReaper at 17:11, 15 July 2014

2014-07-15T17:11:01Z

← Older revision		Revision as of 12:11, 15 July 2014
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	* Do not combine DPH with any other depressant drugs.		* Do not combine DPH with any other depressant drugs.

			= Links =

			* [http://www.erowid.org/pharms/diphenhydramine/diphenhydramine.shtml Erowid]

			* [https://en.wikipedia.org/wiki/Diphenhydramine Wikipedia]

	[[Category:Drugs]]		[[Category:Drugs]]
	[[Category:Deliriant]]		[[Category:Deliriant]]
	[[Category:Depressant]]		[[Category:Depressant]]

GrimReaper at 17:08, 15 July 2014

2014-07-15T17:08:49Z

← Older revision		Revision as of 12:08, 15 July 2014
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	~~= General information =~~

	Diphenhydramine (DPH, also sold as Benadryl) is an antihistamine with anticholinergic and sedative effects. It is found in both OTC and prescription drugs used in the treatment of allergy-related symptoms, some cold and flu symptoms, insomnia, motion sickness and Parkinson's disease. It has also been researched for many other medicinal uses, including the treatment of OCD.		Diphenhydramine (DPH, also sold as Benadryl) is an antihistamine with anticholinergic and sedative effects. It is found in both OTC and prescription drugs used in the treatment of allergy-related symptoms, some cold and flu symptoms, insomnia, motion sickness and Parkinson's disease. It has also been researched for many other medicinal uses, including the treatment of OCD.

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	* Dysphoria		* Dysphoria

	=Harm Reduction=		= Chemistry and Pharmacology =
			[[File:DPH_molecule.png\|110px\|right]]
			Chemical name: 2-(diphenylmethoxy)-N,N-dimethylethanamine

			Diphenhydramine is an inverse agonist of the histamine H1 receptor. It is a member of the ethanolamine class of antihistaminergic agents. By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. Diphenhydramine also crosses the blood–brain barrier and antagonizes the H1 receptors centrally. Its effects on central H1receptors cause drowsiness.

			= Harm Reduction =

	* Many oral diphenhydramine preparations contain analgesics such as acetaminophen/paracetamol or aspirin, which can be toxic to the liver in high doses. Some adulterants, such as paracetamol, can be removed by [[Cold Water Extraction]].		* Many oral diphenhydramine preparations contain analgesics such as acetaminophen/paracetamol or aspirin, which can be toxic to the liver in high doses. Some adulterants, such as paracetamol, can be removed by [[Cold Water Extraction]].

GrimReaper: /* Neutral */

2014-07-14T18:29:35Z

Neutral

← Older revision		Revision as of 13:29, 14 July 2014
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	== Neutral ==		== Neutral ==

	* Dream-like experiences

	* Visual distortions		* Visual distortions

GrimReaper: /* Positive */

2014-07-14T18:29:01Z

Positive

← Older revision		Revision as of 13:29, 14 July 2014
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	== Positive ==		== Positive ==
			* Increased awareness and appreciation of music
			* Dream-like experiences
			* Vivid hallucinations
			* Muscle relaxation

	== Neutral ==		== Neutral ==