DXM - Revision history

Trees: /* Dosage */ added warning about using enzyme inhibition to adjust the high of polistyrex

2023-04-09T00:04:20Z

Dosage: added warning about using enzyme inhibition to adjust the high of polistyrex

← Older revision		Revision as of 19:04, 8 April 2023
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	* HBR and Polistirex doses vary significantly due to polistirex slow absorbsion rate.		* HBR and Polistirex doses vary significantly due to polistirex slow absorbsion rate.
	**Dextromethorphan Polistrex, being extended release, means that your enzyme is more able to convert dxm into dxo. DXO being a more physical, less trippy drug, leads to this preparation of dxm feeling much less intense, and in many cases, very subtle. It is recommended to predose with grapefruit juice to fully enjoy polistrex because it slows down the conversion of dxm to dxo, effectively making polistrex "more trippy" because of a higher amount of dxm that didn't get converted.		**Dextromethorphan Polistrex, being extended release, means that your enzyme is more able to convert dxm into dxo. DXO being a more physical, less trippy drug, leads to this preparation of dxm feeling much less intense, and in many cases, very subtle. It is therefor recommended by some to predose with grapefruit juice to fully enjoy polistrex because it slows down the conversion of dxm to dxo, effectively making polistrex "more trippy" because of a higher amount of dxm that didn't get converted. <u>It should be noted that inhibiting digestive enzymes with grapefruit juice is risky and can interact with several medications and drugs and not be taken lightly.</u> For more information look up "CYP3A4 Inhibition drug interactions".

	* '''DXM doses are affected by weight'''. For more accurate dosage information, see the following resources:		* '''DXM doses are affected by weight'''. For more accurate dosage information, see the following resources:

Lightning po: Added kidney stone possibility and reference

2021-06-18T08:00:40Z

Added kidney stone possibility and reference

← Older revision		Revision as of 03:00, 18 June 2021
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	\| Guaifenesin is an expectorant.		\| Guaifenesin is an expectorant.
	\| Robitussin DM, Mucinex, Robefen		\| Robitussin DM, Mucinex, Robefen
	\| Guaifenesin overdoses cause severe nausea and vomiting in most users.		\| Guaifenesin overdoses cause severe nausea and vomiting in most users. Guaifenesin can also cause kidney stones with chronic use.<ref>https://pubmed.ncbi.nlm.nih.gov/15673990/</ref>
	\|-		\|-
	\| Antihistamines		\| Antihistamines

Lightning po at 03:40, 27 May 2020

2020-05-27T03:40:41Z

← Older revision		Revision as of 22:40, 26 May 2020
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	Third Plateau is a full on dissociative experience. At this point it is no longer a social drug and should be done alone or with a tripsitter. The third plateau is considerably more sedating and movement becomes a bit harder. Closed eye visuals are more prominent at this level. You will lose track of time quit easily as it becomes meaningless quite quickly. Large amounts of dissociation happens at this level, and the internal thoughts can be quite interesting. To explain further, you may start to feel like you don't belong in your own body, or that your mind and body are two separate beings. Additionally, thoughts may be similar to "My body is only what everyone else sees but not really me, because I am just my mind, not my body."		Third Plateau is a full on dissociative experience. At this point it is no longer a social drug and should be done alone or with a tripsitter. The third plateau is considerably more sedating and movement becomes a bit harder. Closed eye visuals are more prominent at this level. You will lose track of time quit easily as it becomes meaningless quite quickly. Large amounts of dissociation happens at this level, and the internal thoughts can be quite interesting. To explain further, you may start to feel like you don't belong in your own body, or that your mind and body are two separate beings. Additionally, thoughts may be similar to "My body is only what everyone else sees but not really me, because I am just my mind, not my body."

	There is a little bit of trip amnesia starting at 3rd Plateau. As stated previously, 3rd Plateau is quite intense. It's not the full comatose stage that the 4th Plateau is, but it can be pretty overwhelming nonetheless.		There is a little bit of post-trip amnesia starting at 3rd Plateau. As stated previously, 3rd Plateau is quite intense. It's not the full comatose stage that the 4th Plateau is, but it can be pretty overwhelming nonetheless.

	'''Third Plateau dose: 7.5-15 mg/kg.'''		'''Third Plateau dose: 7.5-15 mg/kg.'''

Lightning po at 03:40, 27 May 2020

2020-05-27T03:40:11Z

← Older revision		Revision as of 22:40, 26 May 2020
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	Third Plateau is a full on dissociative experience. At this point it is no longer a social drug and should be done alone or with a tripsitter. The third plateau is considerably more sedating and movement becomes a bit harder. Closed eye visuals are more prominent at this level. You will lose track of time quit easily as it becomes meaningless quite quickly. Large amounts of dissociation happens at this level, and the internal thoughts can be quite interesting. To explain further, you may start to feel like you don't belong in your own body, or that your mind and body are two separate beings. Additionally, thoughts may be similar to "My body is only what everyone else sees but not really me, because I am just my mind, not my body."		Third Plateau is a full on dissociative experience. At this point it is no longer a social drug and should be done alone or with a tripsitter. The third plateau is considerably more sedating and movement becomes a bit harder. Closed eye visuals are more prominent at this level. You will lose track of time quit easily as it becomes meaningless quite quickly. Large amounts of dissociation happens at this level, and the internal thoughts can be quite interesting. To explain further, you may start to feel like you don't belong in your own body, or that your mind and body are two separate beings. Additionally, thoughts may be similar to "My body is only what everyone else sees but not really me, because I am just my mind, not my body."

			There is a little bit of trip amnesia starting at 3rd Plateau. As stated previously, 3rd Plateau is quite intense. It's not the full comatose stage that the 4th Plateau is, but it can be pretty overwhelming nonetheless.

	'''Third Plateau dose: 7.5-15 mg/kg.'''		'''Third Plateau dose: 7.5-15 mg/kg.'''

Lightning po at 03:21, 27 May 2020

2020-05-27T03:21:06Z

← Older revision		Revision as of 22:21, 26 May 2020
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	\| Found in Allergy/Sleep/Nighttime medications		\| Found in Allergy/Sleep/Nighttime medications
	\| Coricidin Cough and Cold, Zicam, Dimetapp, Chloraseptic		\| Coricidin Cough and Cold, Zicam, Dimetapp, Chloraseptic
	\| When taken in high doses antihistamines can cause dizzyness, nausea, a strong dysphoria, paranoia, delirium and hallucinations. Many antihistamines can also have a dangerous synergy with DXM		\| When taken in high doses antihistamines can cause dizzyness, nausea, a strong dysphoria, paranoia, delirium and hallucinations. Many antihistamines can also have a dangerous synergy with DXM which can lead to liver, kidney and heart complications.
	\|-		\|-
	\| PPA, pseudoephedrine, and phenyleprine		\| PPA, pseudoephedrine, and phenyleprine

Lightning po: /* Adulteration */

2020-05-27T03:17:16Z

Adulteration

← Older revision		Revision as of 22:17, 26 May 2020
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	\| a painkiller found in headache/flu medicine		\| a painkiller found in headache/flu medicine
	\| Tylenol, Vicks (NyQuil), TheraFlu, Triaminic		\| Tylenol, Vicks (NyQuil), TheraFlu, Triaminic
	\| is ~~hepatoxic~~ in high doses. This means it will damage your liver if taken in high doses. Your body can only process a certain amount of APAP at once before it the normal pathways become saturated Once the regular pathways used for metabolizing APAP have been saturated the remaining APAP gets broken down in the liver by an enzyme called ''cytochrome P450'' '''When forced to break down APAP this enzyme produces toxic metabolites!'''		\| APAP is Hepatoxic in high doses. This means it will damage your liver if taken in high doses. Your body can only process a certain amount of APAP at once before it the normal pathways become saturated. Once the regular pathways used for metabolizing APAP have been saturated, the remaining APAP gets broken down in the liver by an enzyme called ''cytochrome P450'' '''When forced to break down APAP this enzyme produces toxic metabolites!'''
	\|-		\|-
	\| Guaifenesin		\| Guaifenesin

Lightning po at 03:12, 27 May 2020

2020-05-27T03:12:22Z

← Older revision		Revision as of 22:12, 26 May 2020
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	=== Third Plateau ===		=== Third Plateau ===

	Third Plateau is a full on dissociative experience. ~~You cannot ignore the feeling inside of you and at~~ this point ~~its~~ no longer a social drug and should be done ~~by yourself~~ or with a ~~sitter~~. The third plateau ~~isn't 'party-mode' or even 'socialize-mode'. Its~~ more ~~like 'alone-~~and~~-tripping-mode'~~. Closed eye visuals are more prominent at this level. You will lose track of time quit easily as it becomes meaningless quite quickly. Large amounts of dissociation happens at this level, and the internal thoughts can be quite interesting. To explain further, you may start to feel like you don't belong in your own body, or that your mind and body are two separate beings. Additionally, thoughts may be similar to "My body is only what everyone else sees but not really me, because I am just my mind, not my body."		Third Plateau is a full on dissociative experience. At this point it is no longer a social drug and should be done alone or with a tripsitter. The third plateau is considerably more sedating and movement becomes a bit harder. Closed eye visuals are more prominent at this level. You will lose track of time quit easily as it becomes meaningless quite quickly. Large amounts of dissociation happens at this level, and the internal thoughts can be quite interesting. To explain further, you may start to feel like you don't belong in your own body, or that your mind and body are two separate beings. Additionally, thoughts may be similar to "My body is only what everyone else sees but not really me, because I am just my mind, not my body."

	'''Third Plateau dose: 7.5-15 mg/kg.'''		'''Third Plateau dose: 7.5-15 mg/kg.'''

Lightning po: /* Second Plateau */

2020-05-27T03:09:09Z

Second Plateau

← Older revision		Revision as of 22:09, 26 May 2020
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	Most people stop their DXM journey here, as the higher two plateaus are not really '''fun''' but ''introspective'' and ''enlightening''. We don't recommend crossing this threshold until you're ready to move on from a lighter, happier experience to a sometimes darker and definitely more introspective full blown trip. Enjoy the 2nd plateau as long as you can because it's more of a fun experience and one tends to enjoy second plateau less after visiting the third plateau. "Once you see what's behind the curtain, you can't enjoy the show" so they say.		Most people stop their DXM journey here, as the higher two plateaus are not really '''fun''' but ''introspective'' and ''enlightening''. We don't recommend crossing this threshold until you're ready to move on from a lighter, happier experience to a sometimes darker and definitely more introspective full blown trip. Enjoy the 2nd plateau as long as you can because it's more of a fun experience and one tends to enjoy second plateau less after visiting the third plateau. "Once you see what's behind the curtain, you can't enjoy the show" so they say.

	Additionally, ~~exactly~~ at 7.5mg/kg there is an elusive "Eiffel Tower" dose where you may experience the effects of both the Second and Third plateaus ~~simultaneously~~.		Additionally, approximate at 7.5mg/kg there is an elusive "Eiffel Tower" dose where you may experience the effects of both the Second and Third plateaus in waves.

	=== Third Plateau ===		=== Third Plateau ===

Lightning po: /* Lozenges */

2020-05-27T03:06:29Z

Lozenges

← Older revision		Revision as of 22:06, 26 May 2020
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	There are also sore-throat and cough medications containing DXM which exist in the form of a hard-candy like lozenge. These sometimes contain only DXM, however most brands of DXM lozenges also contain analgesics such as acetaminophen or benzocaine.		There are also sore-throat and cough medications containing DXM which exist in the form of a hard-candy like lozenge. These sometimes contain only DXM, however most brands of DXM lozenges also contain analgesics such as acetaminophen or benzocaine.

	~~As always when using lozenges,~~ choose a product which only has ~~DXM~~ in ~~it.~~		Always choose a product which only has Dextromethorphan in the active ingredients!

	=== Syrup ===		=== Syrup ===

Lightning po: changed wording about extractions

2020-05-27T03:04:38Z

changed wording about extractions

← Older revision		Revision as of 22:04, 26 May 2020
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	While there are some products available which contain only DXM as active medical ingredients it is common to find products which contain DXM but also contain enough of another active ingredient to pose a serious risk to the user's health.		While there are some products available which contain only DXM as active medical ingredients it is common to find products which contain DXM but also contain enough of another active ingredient to pose a serious risk to the user's health.

	=== ~~Extracted~~ ===		=== Pure/Extractions ===

	The ideal source of DXM would be pure powder or an extraction, ~~but that~~ requires time and a chemical procedure which most people are not equipped to do. ~~It's not a complicated process~~, ~~however it does carry~~ some ~~risks~~. ~~There is a technique known as the 'Agent Lemon extraction'~~.		The ideal source of DXM would be the purest. The safest way to use dxm is with pure powder (and at least 5-10ml propylene glycol to aid digestion) or an extraction. However, for most this form will prove impractical due to obtaining the pure powder.

			Extractions from OTC sources requires time and a chemical procedure which most people are not equipped to do safely. If you are properly equipped, there is some detailed information on this page: https://erowid.org/chemicals/dxm/faq/dxm_chemistry.shtml

	===Gel Caps===		===Gel Caps===

	DXM Gelcaps such as Robitussin Gelcaps or other ~~no-name-brand~~ products containing only DXM encased in a gelcap are often the preferred source for DXM users. For most users, gelcaps which contain only DXM produce a more clear headed high in lower doses. Most users experience fewer side effects from gelcaps than from syrup, however some users report an upset stomach, indicating that some users may have a sensitivity to the edible plastics used to make the gelcaps.		DXM Gelcaps such as Robitussin Gelcaps or other products containing only DXM encased in a gelcap are often the preferred source for DXM users. For most users, gelcaps which contain only DXM produce a more clear headed high in lower doses (slower digestion, see . Most users experience fewer side effects from gelcaps than from syrup, however some users report an upset stomach, indicating that some users may have a sensitivity to the edible plastics used to make the gelcaps.

	Some brands such as '''Cordicin Cough and Cold''' (also known as '''CCC''') have a variety of products, most of which contain other active ingredients such as antihistamines or CPM (Chlorpheniramine Maleate) and may have one or two products which contain only DXM.		Some brands such as '''Cordicin Cough and Cold''' (also known as '''CCC''') have a variety of products, most of which contain other active ingredients such as antihistamines or CPM (Chlorpheniramine Maleate) and may have one or two products which contain only DXM.
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	Around 10 percent of the Caucasian population has little or no CYP2D6 enzyme activity, leading to long-lived high drug levels. ALL Caucasians should take a small test dose (1st plateau or medical levels) to feel for this ahead of time.		Around 10 percent of the Caucasian population has little or no CYP2D6 enzyme activity, leading to long-lived high drug levels. ALL Caucasians should take a small test dose (1st plateau or medical levels) to feel for this ahead of time.



	== Images ==		== Images ==