Alprazolam - Revision history

Toasterlizard: that /other/ link

2015-06-26T10:23:14Z

that /other/ link

← Older revision		Revision as of 05:23, 26 June 2015
Line 102:		Line 102:
	The LD50 of Alprazolam in rats is 331-2171mg/kg.		The LD50 of Alprazolam in rats is 331-2171mg/kg.

	An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed [[Benzodiazepines\|benzodiazepine]] in the U.S. by a large margin, to be more toxic than diazepam and other [[Benzodiazepines\|benzodiazepines]].		An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed [[Benzodiazepines\|benzodiazepine]] in the U.S. by a large margin, to be more toxic than [[Diazepam\|diazepam]] and other [[Benzodiazepines\|benzodiazepines]].

	== Legal Status ==		== Legal Status ==

Toasterlizard: Links! All the links! ... okay, perhaps just a few links.

2015-06-26T10:08:12Z

Links! All the links! ... okay, perhaps just a few links.

← Older revision		Revision as of 05:08, 26 June 2015
Line 1:		Line 1:
	[[File:Xanax.jpg\|250px\|right]]		[[File:Xanax.jpg\|250px\|right]]
	'''Alprazolam''' is a short acting anxiolytic of the benzodiazepine class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is available in both instant and time released version.		'''Alprazolam''' is a short acting anxiolytic of the [[Benzodiazepines\|benzodiazepine]] class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is available in both instant and time released version.

	== History ==		== History ==
Line 85:		Line 85:
	== Harm Reduction ==		== Harm Reduction ==

	When on high doses of benzodiazepines, users are likely to black out and potentially hurt themselves through a variety of adventures. If you are using it as a sleep aid, it's ~~reccomended~~ to continue doing what you're doing until you begin to feel drowsy, then go to bed.		When on high doses of [[Benzodiazepines\|benzodiazepines]], users are likely to black out and potentially hurt themselves through a variety of adventures. If you are using it as a sleep aid, it's recommended to continue doing what you're doing until you begin to feel drowsy, then go to bed.

	Some users report Alprazolam (and benzodiazepines in general) to lead to compulsive redosing, trying to find a “high” which is where a fair amount of the point above comes from. To avoid this keep doses low and be wary of reduced inhibitions while under the influence of Alprazolam.		Some users report Alprazolam (and [[Benzodiazepines\|benzodiazepines]] in general) to lead to compulsive redosing, trying to find a “high” which is where a fair amount of the point above comes from. To avoid this keep doses low and be wary of reduced inhibitions while under the influence of Alprazolam.

	=== Interactions ===		=== Interactions ===
Line 102:		Line 102:
	The LD50 of Alprazolam in rats is 331-2171mg/kg.		The LD50 of Alprazolam in rats is 331-2171mg/kg.

	An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed benzodiazepine in the U.S. by a large margin, to be more toxic than diazepam and other benzodiazepines.		An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed [[Benzodiazepines\|benzodiazepine]] in the U.S. by a large margin, to be more toxic than diazepam and other [[Benzodiazepines\|benzodiazepines]].

	== Legal Status ==		== Legal Status ==

GrimReaper at 09:58, 10 March 2015

2015-03-10T09:58:43Z

← Older revision		Revision as of 04:58, 10 March 2015
Line 1:		Line 1:
	[[File:Xanax.jpg\|250px\|right]]		[[File:Xanax.jpg\|250px\|right]]
	Alprazolam is a short acting anxiolytic of the benzodiazepine class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is available in both instant and time released version.		'''Alprazolam''' is a short acting anxiolytic of the benzodiazepine class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is available in both instant and time released version.

	= History =		== History ==

	Alprazolam was first released by Upjohn, under the brand name Xanax. The patent was filed in October 1969, granted in October of 1976, and expired in September of 1993. It was first released in 1981, for the treatment of panic disorders.		Alprazolam was first released by Upjohn, under the brand name Xanax. The patent was filed in October 1969, granted in October of 1976, and expired in September of 1993. It was first released in 1981, for the treatment of panic disorders.

	= Formulations =		== Formulations ==

	Instant release tablets are available in 0.25mg, 0.5mg, 1mg, and 2mg.		Instant release tablets are available in 0.25mg, 0.5mg, 1mg, and 2mg.
Line 14:		Line 14:
	Oral solutions are available in 0.5mg/5mL and as 1mg/1mL solutions.		Oral solutions are available in 0.5mg/5mL and as 1mg/1mL solutions.

	= Dosage =		== Dosage ==

	Note: Higher doses have an increased risk of blacking out.		Note: Higher doses have an increased risk of blacking out.
Line 36:		Line 36:
	\|}		\|}

	= Duration =		== Duration ==

	Note: Duration can be significantly longer with higher doses.		Note: Duration can be significantly longer with higher doses.
Line 51:		Line 51:
	\|}		\|}

	= Effects =		== Effects ==

	== Positive ==		=== Positive ===

	*Euphoria		*Euphoria
Line 60:		Line 60:

	*Anti-Anxiety effects		*Anti-Anxiety effects
	== Neutral ==		=== Neutral ===

	*Drowsiness		*Drowsiness

	*Appetite fluctuation		*Appetite fluctuation
	== Negative ==		=== Negative ===

	*Memory loss		*Memory loss
Line 83:		Line 83:
	*Emotional and social dissociation or de-realization (long term use)		*Emotional and social dissociation or de-realization (long term use)

	= Harm Reduction =		== Harm Reduction ==

	When on high doses of benzodiazepines, users are likely to black out and potentially hurt themselves through a variety of adventures. If you are using it as a sleep aid, it's reccomended to continue doing what you're doing until you begin to feel drowsy, then go to bed.		When on high doses of benzodiazepines, users are likely to black out and potentially hurt themselves through a variety of adventures. If you are using it as a sleep aid, it's reccomended to continue doing what you're doing until you begin to feel drowsy, then go to bed.
Line 89:		Line 89:
	Some users report Alprazolam (and benzodiazepines in general) to lead to compulsive redosing, trying to find a “high” which is where a fair amount of the point above comes from. To avoid this keep doses low and be wary of reduced inhibitions while under the influence of Alprazolam.		Some users report Alprazolam (and benzodiazepines in general) to lead to compulsive redosing, trying to find a “high” which is where a fair amount of the point above comes from. To avoid this keep doses low and be wary of reduced inhibitions while under the influence of Alprazolam.

	== Interactions ==		=== Interactions ===

	As with other depressants, Alprazolam should not be combined with any other CNS depressants (such as [[Alcohol]]), at the risk of respiratory depression, which can lead to death.		As with other depressants, Alprazolam should not be combined with any other CNS depressants (such as [[Alcohol]]), at the risk of respiratory depression, which can lead to death.
	See the [[Drug combinations]] chart for more information.		See the [[Drug combinations]] chart for more information.

	= Chemistry and Pharmacology =		== Chemistry and Pharmacology ==

	Alprazolam is absorbed fairly rapidly, with peak plasma levels achieved around the one-two hour mark.		Alprazolam is absorbed fairly rapidly, with peak plasma levels achieved around the one-two hour mark.
Line 104:		Line 104:
	An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed benzodiazepine in the U.S. by a large margin, to be more toxic than diazepam and other benzodiazepines.		An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed benzodiazepine in the U.S. by a large margin, to be more toxic than diazepam and other benzodiazepines.

	= Legal Status =		== Legal Status ==
	==USA==		===USA===
	Alprazolam is a schedule IV substance.		Alprazolam is a schedule IV substance.
	==UK==		===UK===
	Under the UK drug misuse classification system benzodiazepines are class C drugs (Schedule 4).		Under the UK drug misuse classification system benzodiazepines are class C drugs (Schedule 4).
	==Ireland==		===Ireland===
	Alprazolam is a schedule 4 medicine.		Alprazolam is a schedule 4 medicine.
	==Sweden==		===Sweden===
	Alprazolam is a prescription drug in List IV under the Narcotic Drugs Act (1968).		Alprazolam is a prescription drug in List IV under the Narcotic Drugs Act (1968).
	==Netherlands==		===Netherlands===
	Alprazolam is a List 2 substance of the Opium Law and is available for prescription.		Alprazolam is a List 2 substance of the Opium Law and is available for prescription.
	==Australia==		===Australia===
	Alprazolam was orginally a Schedule 4 (prescription only) medication; yet as of February 2014 it has become a Schedule 8 medication.		Alprazolam was orginally a Schedule 4 (prescription only) medication; yet as of February 2014 it has become a Schedule 8 medication.

GrimReaper: /* Chemistry and Pharmacology */

2015-02-28T21:32:52Z

Chemistry and Pharmacology

← Older revision		Revision as of 16:32, 28 February 2015
Line 101:		Line 101:

	The LD50 of Alprazolam in rats is 331-2171mg/kg.		The LD50 of Alprazolam in rats is 331-2171mg/kg.

			An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed benzodiazepine in the U.S. by a large margin, to be more toxic than diazepam and other benzodiazepines.

	= Legal Status =		= Legal Status =

Toasterlizard: /* Dosage */

2015-01-14T00:33:57Z

Dosage

← Older revision		Revision as of 19:33, 13 January 2015
Line 20:		Line 20:
	{\| class="wikitable"		{\| class="wikitable"
	\|+ Oral		\|+ Oral
	\| Light \|\|.25-.5mg		\| Light \|\|0.25-0.5mg

	\|-		\|-

Roi: fix link

2015-01-13T23:26:54Z

fix link

← Older revision		Revision as of 18:26, 13 January 2015
Line 98:		Line 98:
	Alprazolam is absorbed fairly rapidly, with peak plasma levels achieved around the one-two hour mark.		Alprazolam is absorbed fairly rapidly, with peak plasma levels achieved around the one-two hour mark.

	It is primarily metabilised via CYP3A4. Alprazolam is a chemical analogue of triazolam. It is a triazolobenzodiazepine. It binds to the GABA(a) receptor and modulates the function of the GABA receptor. You can learn more about the GABA(a) receptor ~~here.~~ [~~url]~~[~~[http://wiki.tripsit.me/wiki/GABA_Receptors_and_Subunits_Info~~]]~~[/url]~~		It is primarily metabilised via CYP3A4. Alprazolam is a chemical analogue of triazolam. It is a triazolobenzodiazepine. It binds to the GABA(a) receptor and modulates the function of the GABA receptor. You can learn more about the GABA(a) receptor [[GABA Receptors and Subunits Info\|here]].

	The LD50 of Alprazolam in rats is 331-2171mg/kg.		The LD50 of Alprazolam in rats is 331-2171mg/kg.

Roi at 23:25, 13 January 2015

2015-01-13T23:25:18Z

← Older revision		Revision as of 18:25, 13 January 2015
Line 1:		Line 1:
	[[File:Xanax.jpg\|250px\|right]]		[[File:Xanax.jpg\|250px\|right]]
	Alprazolam, is a short acting anxiolytic of the benzodiazepine class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is ~~found~~ in ~~IR tablets~~ and ~~XR forumulations~~.		Alprazolam is a short acting anxiolytic of the benzodiazepine class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is available in both instant and time released version.

	= History =		= History =

	Alprazolam was first released by ~~Pfizer~~, under the brand name Xanax. The patent was filed in October 1969, granted in October of 1976, and expired in September of 1993. It was first released in 1981~~. It’s first approved usage was~~ panic ~~disorder~~.		Alprazolam was first released by Upjohn, under the brand name Xanax. The patent was filed in October 1969, granted in October of 1976, and expired in September of 1993. It was first released in 1981, for the treatment of panic disorders.

	= Formulations =		= Formulations =
Line 44:		Line 44:

	\| Onset \|\| 20-40 minutes		\| Onset \|\| 20-40 minutes

			\|-

	\| Duration \|\| 5-8 hours		\| Duration \|\| 5-8 hours
Line 83:		Line 85:
	= Harm Reduction =		= Harm Reduction =

	When on high doses of benzodiazepines, users are likely to black out and potentially hurt themselves through a variety of adventures. If you are using it as a sleep aid, it's reccomended to continue doing what you're doing until you begin to feel drowsy, then go to bed		When on high doses of benzodiazepines, users are likely to black out and potentially hurt themselves through a variety of adventures. If you are using it as a sleep aid, it's reccomended to continue doing what you're doing until you begin to feel drowsy, then go to bed.

	Some users report Alprazolam (~~And~~ benzodiazepines in general) to compulsive redosing, trying to find a “high” which is where a fair amount of the above ~~point~~ comes from. To avoid this keep doses low and be wary of reduced inhibitions while under the influence of Alprazolam		Some users report Alprazolam (and benzodiazepines in general) to lead to compulsive redosing, trying to find a “high” which is where a fair amount of the point above comes from. To avoid this keep doses low and be wary of reduced inhibitions while under the influence of Alprazolam.

	== Interactions ==		== Interactions ==
Line 98:		Line 100:
	It is primarily metabilised via CYP3A4. Alprazolam is a chemical analogue of triazolam. It is a triazolobenzodiazepine. It binds to the GABA(a) receptor and modulates the function of the GABA receptor. You can learn more about the GABA(a) receptor here. [url][[http://wiki.tripsit.me/wiki/GABA_Receptors_and_Subunits_Info]][/url]		It is primarily metabilised via CYP3A4. Alprazolam is a chemical analogue of triazolam. It is a triazolobenzodiazepine. It binds to the GABA(a) receptor and modulates the function of the GABA receptor. You can learn more about the GABA(a) receptor here. [url][[http://wiki.tripsit.me/wiki/GABA_Receptors_and_Subunits_Info]][/url]

	The LD50 of Alprazolam in rats is 331-2171mg/kg		The LD50 of Alprazolam in rats is 331-2171mg/kg.

	= Legal Status =		= Legal Status =
	==USA==		==USA==
	Alprazolam is a schedule IV substance.		Alprazolam is a schedule IV substance.
	==UK==		==UK==
	Under the UK drug misuse classification system benzodiazepines are class C drugs (Schedule 4)		Under the UK drug misuse classification system benzodiazepines are class C drugs (Schedule 4).
	==Ireland==		==Ireland==
	Alprazolam is a schedule 4 medicine.		Alprazolam is a schedule 4 medicine.
	==Sweden==		==Sweden==
	Alprazolam is a prescription drug in List IV under the Narcotic Drugs Act (1968)		Alprazolam is a prescription drug in List IV under the Narcotic Drugs Act (1968).
	==Netherlands==		==Netherlands==
	Alprazolam is a List 2 substance of the Opium Law and is available for prescription.		Alprazolam is a List 2 substance of the Opium Law and is available for prescription.
	==Australia==		==Australia==
	Alprazolam was orginally a Schedule 4 (prescription only) medication; yet as of February 2014, it has become a Schedule 8 medication.		Alprazolam was orginally a Schedule 4 (prescription only) medication; yet as of February 2014 it has become a Schedule 8 medication.

	[[Category:Drugs]]		[[Category:Drugs]]

GrimReaper at 23:18, 13 January 2015

2015-01-13T23:18:58Z

← Older revision		Revision as of 18:18, 13 January 2015
Line 1:		Line 1:
	[[File:Xanax.jpg\|250px\|right]]		[[File:Xanax.jpg\|250px\|right]]


	Alprazolam, is a short acting anxiolytic of the benzodiazepine class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is found in IR tablets and XR forumulations.		Alprazolam, is a short acting anxiolytic of the benzodiazepine class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is found in IR tablets and XR forumulations.

GrimReaper at 23:18, 13 January 2015

2015-01-13T23:18:42Z

← Older revision		Revision as of 18:18, 13 January 2015
Line 1:		Line 1:
			[[File:Xanax.jpg\|250px\|right]]


	Alprazolam, is a short acting anxiolytic of the benzodiazepine class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is found in IR tablets and XR forumulations.		Alprazolam, is a short acting anxiolytic of the benzodiazepine class of drugs. It is commonly used and FDA approved for the treatment of panic disorders and anxiety disorders, such as GAD/SAD. It is found in IR tablets and XR forumulations.

GrimReaper at 23:15, 13 January 2015

2015-01-13T23:15:02Z

← Older revision		Revision as of 18:15, 13 January 2015
Line 111:		Line 111:
	==Australia==		==Australia==
	Alprazolam was orginally a Schedule 4 (prescription only) medication; yet as of February 2014, it has become a Schedule 8 medication.		Alprazolam was orginally a Schedule 4 (prescription only) medication; yet as of February 2014, it has become a Schedule 8 medication.

			[[Category:Drugs]]

			[[Category:Benzodiazepine]]

			[[Category:Depressant]]