3-MeO-PCP - Revision history

Sleep: /* Duration */

2015-03-14T23:11:11Z

Duration

← Older revision		Revision as of 18:11, 14 March 2015
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	\|-		\|-

	\| Total \|\| 4-6 hours		\| Total \|\| 3-5 hours +/- 60 minutes, dependent on dose.

	\|-		\|-
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	\|}		\|}

	Insufflated ~~onset is approximately 5~~-15 minutes ~~and the duration is a bit shorter~~.		{\| class="wikitable"

			\|+ Insufflated

			\|-

			\| Onset \|\| 10-30 minutes

			\|-

			\| Total \|\| 2-4 hours +/- ~30 minutes, dependent on dose.

			\|-

			\| After-effects \|\| 2-48 hours

			\|}

	== Effects ==		== Effects ==

Sleep: /* Dosage */

2015-03-14T23:07:03Z

Dosage

← Older revision		Revision as of 18:07, 14 March 2015
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	\|-		\|-

	\| Heavy \|\| 15-~~18mg~~+		\| Heavy \|\| 15-18 mg+

	\|}		\|}
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	\|-		\|-

	\| Heavy \|\| 12-~~15mg~~+		\| Heavy \|\| 12-15 mg+

	\|}		\|}

Sleep: /* Dosage */

2015-03-14T23:06:34Z

Dosage

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 | Light || 3-5 mg
 |-
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 | Strong || 8-12 mg
 |}

GrimReaper at 09:32, 10 March 2015

2015-03-10T09:32:29Z

← Older revision		Revision as of 04:32, 10 March 2015
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	[[File:3meopcp.jpg\|right\|3-MeO-PCP in a pill form]]		[[File:3meopcp.jpg\|right\|3-MeO-PCP in a pill form]]

			'''3-Methoxyphencyclidine''' (3-MeO-PCP) is a dissociative anesthetic drug that is sold online as a research chemical.
	3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative anesthetic drug that is sold online as a research chemical.

	The effects are often described as being more euphoric and mentally clearer than many related compounds.		The effects are often described as being more euphoric and mentally clearer than many related compounds.

	= History =		== History ==

	A 1965 article published by Maddox described the synthesis of 2-MeO-PCP and 4-MeO-PCP. Preparation of 3-MeO-PCP was described later in 1979 by Geneste et al.		A 1965 article published by Maddox described the synthesis of 2-MeO-PCP and 4-MeO-PCP. Preparation of 3-MeO-PCP was described later in 1979 by Geneste et al.
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	The compound was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine derivatives. The activity of 3-MeO-PCP in man was not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency.		The compound was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine derivatives. The activity of 3-MeO-PCP in man was not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency.

	= Dosage =		== Dosage ==

	3-MeO-PCP, like PCP is active in the single milligram range and therefor can be hard to accurately measure.		3-MeO-PCP, like PCP is active in the single milligram range and therefor can be hard to accurately measure.
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	Insufflated onset is approximately 5-15 minutes and the duration is a bit shorter.		Insufflated onset is approximately 5-15 minutes and the duration is a bit shorter.

	= Effects =		== Effects ==

	== Positive ==		=== Positive ===

	* Increase in energy / stimulation		* Increase in energy / stimulation
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	* Shifts in perception of reality		* Shifts in perception of reality

	== Neutral ==		=== Neutral ===

	* Increased heart rate (lower doses)		* Increased heart rate (lower doses)
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	* Confusion, disorientation		* Confusion, disorientation

	== Negative ==		=== Negative ===

	* Disturbing hallucinations and/or delusions		* Disturbing hallucinations and/or delusions
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	* Severe distortion or loss of auditory/visual perception		* Severe distortion or loss of auditory/visual perception

	= Harm Reduction =		== Harm Reduction ==

	* 3-Meo-PCP is a very powerful NMDA antagonist (doses are on par with [[PCP]]), and as such it has the potential to be very confusing.		* 3-Meo-PCP is a very powerful NMDA antagonist (doses are on par with [[PCP]]), and as such it has the potential to be very confusing.
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	* It is difficult to measure 3-MeO-PCP accurately with a scale because it is active in the 1-10 mg range. See [http://wiki.tripsit.me/wiki/3-MeO-PCP#Dosage the dosage section] for more information.		* It is difficult to measure 3-MeO-PCP accurately with a scale because it is active in the 1-10 mg range. See [http://wiki.tripsit.me/wiki/3-MeO-PCP#Dosage the dosage section] for more information.
	* 3-MeO-PCP has a steep dose-response-curve and an onset ranging from approximately 20-40 minutes. It is inadvisable to redose, especially within the first hour.		* 3-MeO-PCP has a steep dose-response-curve and an onset ranging from approximately 20-40 minutes. It is inadvisable to redose, especially within the first hour.


	For more information see [http://wiki.tripsit.me/wiki/Dissociatives#Harm_Reduction Dissociative Harm-Reduction].		For more information see [http://wiki.tripsit.me/wiki/Dissociatives#Harm_Reduction Dissociative Harm-Reduction].

			=== Interactions ===
	== Interactions ==

	Check out our [[Drug Combinations]] page and chart for interactions and combinations of common drugs.		Check out our [[Drug Combinations]] page and chart for interactions and combinations of common drugs.
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	Specifically, do not mix 3-MeO-PCP with alcohol or benzodiazepines. 3-MeO-PCP will also likely produce synergistic effects if used in conjunction with certain serotogenic medications or drugs.		Specifically, do not mix 3-MeO-PCP with alcohol or benzodiazepines. 3-MeO-PCP will also likely produce synergistic effects if used in conjunction with certain serotogenic medications or drugs.

			== Chemistry and Pharmacology ==
	= Chemistry and Pharmacology =

	3-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP. It is also a Serotonin Reuptake Inhibitor (SRI).		3-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP. It is also a Serotonin Reuptake Inhibitor (SRI).
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	3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter and 42 for the sigma1 receptor.		3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter and 42 for the sigma1 receptor.

	= Legal status=		== Legal status ==

	UK: Class B, as are all arylcyclohexamines.		UK: Class B, as are all arylcyclohexamines.
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	US: Covered by the analogue act if sold for human consumption.		US: Covered by the analogue act if sold for human consumption.

	= Links =		== Links ==

	[https://en.wikipedia.org/wiki/3-MeO-PCP Wikipedia]		[https://en.wikipedia.org/wiki/3-MeO-PCP Wikipedia]

GrimReaper at 00:31, 24 January 2015

2015-01-24T00:31:17Z

← Older revision		Revision as of 19:31, 23 January 2015
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			[[File:3meopcp.jpg\|right\|3-MeO-PCP in a pill form]]


	3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative anesthetic drug that is sold online as a research chemical.		3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative anesthetic drug that is sold online as a research chemical.

Sleep at 20:15, 23 December 2014

2014-12-23T20:15:51Z

← Older revision		Revision as of 15:15, 23 December 2014
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	[[Category:Dissociative]]		[[Category:Dissociative]]

			[[category:Research Chemical]]

Trees: /* Dosage */

2014-10-31T20:12:56Z

Dosage

← Older revision		Revision as of 15:12, 31 October 2014
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	= Dosage =		= Dosage =

	3-MeO-PCP, like PCP is active at the single milligram range and therefor can be hard to accurately measure.		3-MeO-PCP, like PCP is active in the single milligram range and therefor can be hard to accurately measure.

	'''Most if not all consumer-grade jewelry-scales advertised as working at the 0.001g (mg) range are not reliably accurate enough to measure quantities weighing less than around 15-25 mg depending on the model and calibration.		'''Most if not all consumer-grade jewelry-scales advertised as working at the 0.001g (mg) range are not reliably accurate enough to measure quantities weighing less than around 15-25 mg depending on the model and calibration.

Trees at 20:09, 31 October 2014

2014-10-31T20:09:37Z

← Older revision		Revision as of 15:09, 31 October 2014
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	3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative anesthetic drug that is sold online as a research chemical.		3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative anesthetic drug that is sold online as a research chemical.

	The effects are often described as more euphoric and mentally clearer than many related compounds.		The effects are often described as being more euphoric and mentally clearer than many related compounds.

	= History =		= History =
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	= Dosage =		= Dosage =

	~~Use~~ a ~~precise milligram scale~~ to ~~avoid overdosing~~.		3-MeO-PCP, like PCP is active at the single milligram range and therefor can be hard to accurately measure.

			'''Most if not all consumer-grade jewelry-scales advertised as working at the 0.001g (mg) range are not reliably accurate enough to measure quantities weighing less than around 15-25 mg depending on the model and calibration.
			With a drug as potent as 3-MeO-PCP a small discrepancy in measurement can make a world of difference in physical and mental response to the dose.
			It is for these reasons that it would be in one's best interest to use a [https://wiki.tripsit.me/wiki/Quick_Guide_to_Volumetric_Dosing volumetric dose measurement technique as outlined in this guide.]'''

	{\| class="wikitable"		{\| class="wikitable"
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	= Effects =		= Effects =

	== ~~Postive~~ ==		== Positive ==

	* Increase in energy / stimulation		* Increase in energy / stimulation
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	* Increased sociability, loss of inhibitions		* Increased sociability, loss of inhibitions

	* Closed- and open-eye visuals		* Closed and open-eye visuals

	* Shifts in perception of reality		* Shifts in perception of reality
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	= Harm Reduction =		= Harm Reduction =

	~~Do not drive~~ or ~~operate heavy machinery~~. ~~Take extra precaution if going out~~ in ~~public on~~ 3-MeO-PCP.		* 3-Meo-PCP is a very powerful NMDA antagonist (doses are on par with [[PCP]]), and as such it has the potential to be very confusing.
			* 3-MeO-PCP is considered to be a 'research-chemical', simply meaning that there is little to no clinical data on long-term effects.
			* 3-MeO-PCP, as with all arylcyclohexylamine class dissociative compounds may cause neurotoxicity when used frequently or in high dose.
			* 3-MeO-PCP acts as a mild Serotonin Reuptake Inhibitor and as such may risk adverse effects as a result of synergy when used with certain serotogenic drugs or medications. See [http://wiki.tripsit.me/wiki/3-MeO-PCP#Interactions Interactions].
			* It is difficult to measure 3-MeO-PCP accurately with a scale because it is active in the 1-10 mg range. See [http://wiki.tripsit.me/wiki/3-MeO-PCP#Dosage the dosage section] for more information.
			* 3-MeO-PCP has a steep dose-response-curve and an onset ranging from approximately 20-40 minutes. It is inadvisable to redose, especially within the first hour.

	~~== WARNING ==~~

	~~We recommend to have a sober friend with you when taking this substance for the first time~~.		For more information see [http://wiki.tripsit.me/wiki/Dissociatives#Harm_Reduction Dissociative Harm-Reduction].


	== Interactions ==		== Interactions ==

	Check out our [[Drug Combinations]] page and chart for interactions and combinations of common drugs.		Check out our [[Drug Combinations]] page and chart for interactions and combinations of common drugs.
			PCP and 3-MeO-PCP have similar profiles and as such its safe to assume the PCP combination-chart data also applies to 3-MeO-PCP.

			Specifically, do not mix 3-MeO-PCP with alcohol or benzodiazepines. 3-MeO-PCP will also likely produce synergistic effects if used in conjunction with certain serotogenic medications or drugs.

	~~Specifically, do not mix with alcohol or benzodiazepines.~~

	= Chemistry and Pharmacology =		= Chemistry and Pharmacology =

Roi at 18:49, 21 July 2014

2014-07-21T18:49:59Z

Show changes

Trainwreck: /* Effects */

2014-07-21T18:15:57Z

Effects

← Older revision		Revision as of 13:15, 21 July 2014
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	= Effects =		= Effects =
	* Dissociation		* Dissociation from reality
	* Difficulty walking		* Difficulty walking
	* Difficulty talking		* Difficulty talking
	* Time dilation		* Time dilation
	* Music appreciation		* Music appreciation
			* May get stuck in thought loops
	* Produces an inner stillness as if all the leaky naggings of the subconscious are completely muted		* Produces an inner stillness as if all the leaky naggings of the subconscious are completely muted



	= Harm Reduction =		= Harm Reduction =