2C-E - Revision history

Toasterlizard: Reverted edits by Dumbdumb123 (talk) to last revision by Dread

2018-10-09T22:09:43Z

Reverted edits by Dumbdumb123 (talk) to last revision by Dread

← Older revision		Revision as of 17:09, 9 October 2018
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	Note: The prevalence of negative effects increases with higher doses.		Note: The prevalence of negative effects increases with higher doses.

			=== Positive ===

			* Mood lift, euphoria, sense of well-being

			* Enhanced sensory perception

			* Increase in associative & creative thinking; introspection

			* Life-changing 'spiritual' experiences

			* Closed and Open eye visuals, patterning, tracers, color-enhancement, etc.

			* Enhanced appreciation of music

			* Increase in energy

			=== Neutral ===

			* Time dilation

			* Slight increase in heart-rate and body temperature

			* Inability to focus or difficulty focusing

	=== Negative ===		=== Negative ===

Dumbdumb123: Goodbye moonmen

2018-10-09T21:51:23Z

Goodbye moonmen

← Older revision		Revision as of 16:51, 9 October 2018
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	Note: The prevalence of negative effects increases with higher doses.		Note: The prevalence of negative effects increases with higher doses.

	~~=== Neutral ===~~

	* Time dilation

	* Slight increase in heart-rate and body temperature

	* Inability to focus or difficulty focusing

	=== Negative ===		=== Negative ===

Dumbdumb123: Goodbye moonmen

2018-10-09T21:50:27Z

Goodbye moonmen

← Older revision		Revision as of 16:50, 9 October 2018
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	Note: The prevalence of negative effects increases with higher doses.		Note: The prevalence of negative effects increases with higher doses.

	~~=== Positive ===~~

	* Mood lift, euphoria, sense of well-being

	* Enhanced sensory perception

	* Increase in associative & creative thinking; introspection

	* Life-changing 'spiritual' experiences

	* Closed and Open eye visuals, patterning, tracers, color-enhancement, etc.

	* Enhanced appreciation of music

	* Increase in energy

	=== Neutral ===		=== Neutral ===

Dread: factsheet relative dosing table

2016-09-19T17:27:43Z

factsheet relative dosing table

@@ Line 13: / Line 13: @@
 == Dosage ==
-{| class="wikitable"
+{{#tdose: 2ce }}
 == Duration ==

Physical: Fixed a typo - Insulated to insufflated

2016-06-19T06:56:29Z

Fixed a typo - Insulated to insufflated

← Older revision		Revision as of 01:56, 19 June 2016
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	See [[Psychedelics#Harm_Reduction\|Psychedelic Harm Reduction]] for more information.		See [[Psychedelics#Harm_Reduction\|Psychedelic Harm Reduction]] for more information.

	* As with all stimulants, care should be taken when dosing via different ROAs. The oral route has a much lower bioavailabity than those that bypass first pass metabolism i.e. ~~Insulated~~, rectal, intramuscular, intravenous and subcutaneous.		* As with all stimulants, care should be taken when dosing via different ROAs. The oral route has a much lower bioavailabity than those that bypass first pass metabolism i.e. Insufflated, rectal, intramuscular, intravenous and subcutaneous.

	See [[Stimulants#Harm Reduction\|Stimulant Harm Reduction]] for more information.		See [[Stimulants#Harm Reduction\|Stimulant Harm Reduction]] for more information.

Toasterlizard: Corrected "Insulated" to "Insufflated"

2016-06-19T02:10:24Z

Corrected "Insulated" to "Insufflated"

← Older revision		Revision as of 21:10, 18 June 2016
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	{\| class="wikitable"		{\| class="wikitable"

	\|+ ~~Insulated~~		\|+ Insufflated

	\|-		\|-

GrimReaper at 09:04, 10 March 2015

2015-03-10T09:04:13Z

← Older revision		Revision as of 04:04, 10 March 2015
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	[[File:2ce.jpg\|thumb\|150px\|Vial of 2C-E with powder]]		[[File:2ce.jpg\|thumb\|150px\|Vial of 2C-E with powder]]

	2C-E is a chemical of the [[2C-X]] series which is characterised by its particularly intense visuals and higher potency when compared with other members of the family.		'''2C-E''' is a chemical of the [[2C-X]] series which is characterised by its particularly intense visuals and higher potency when compared with other members of the family.

	= History =		== History ==

	2C-E, like many of its close analogues, was first synthesized by Alexander Shulgin and published in PiHKAL. He was quite fond of it, granting it a place in his "Magical Half Dozen" alongside of [[DOM]], [[2C-B]], [[2C-T-2]] & 7 and [[mescaline]].		2C-E, like many of its close analogues, was first synthesized by Alexander Shulgin and published in PiHKAL. He was quite fond of it, granting it a place in his "Magical Half Dozen" alongside of [[DOM]], [[2C-B]], [[2C-T-2]] & 7 and [[mescaline]].

	= ~~Uses~~ =		== Usage ==

	2C-E is mainly a recreational entheogen. It can be quite introspective in appropriate doses and settings. It doesn't lend itself well to intense party-like surroundings, much like LSD or similarly intense psychedelics.		2C-E is mainly a recreational entheogen. It can be quite introspective in appropriate doses and settings. It doesn't lend itself well to intense party-like surroundings, much like LSD or similarly intense psychedelics.

	= Dosage =		== Dosage ==

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	= Duration =		== Duration ==

	Note: Duration can be significantly longer with higher doses.		Note: Duration can be significantly longer with higher doses.
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	\|}		\|}

	= Effects =		== Effects ==

	2C-E is a psychedelic phenethylamine and as such has psychedelic and stimulant effects. As with all psychedelics, different users are likely to experience different sets of effects, which usually include some however very rarely would include all of the following effects.		2C-E is a psychedelic phenethylamine and as such has psychedelic and stimulant effects. As with all psychedelics, different users are likely to experience different sets of effects, which usually include some however very rarely would include all of the following effects.
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	Note: The prevalence of negative effects increases with higher doses.		Note: The prevalence of negative effects increases with higher doses.

	== Positive ==		=== Positive ===

	* Mood lift, euphoria, sense of well-being		* Mood lift, euphoria, sense of well-being
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	* Increase in energy		* Increase in energy

	== Neutral ==		=== Neutral ===

	* Time dilation		* Time dilation
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	* Inability to focus or difficulty focusing		* Inability to focus or difficulty focusing

	== Negative ==		=== Negative ===

	* Tension		* Tension
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	* Racing thoughts		* Racing thoughts

			== Harm Reduction ==
	= Harm Reduction =

	* As with all psychedelic drugs 2C-E carries with it the potential for a very powerful experience, and as such has the potential to create a very difficult experience ('bad' trip). Mindset and setting play important roles in governing the nature of a psychedelic experience, among other things.		* As with all psychedelic drugs 2C-E carries with it the potential for a very powerful experience, and as such has the potential to create a very difficult experience ('bad' trip). Mindset and setting play important roles in governing the nature of a psychedelic experience, among other things.
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	See [[Stimulants#Harm Reduction\|Stimulant Harm Reduction]] for more information.		See [[Stimulants#Harm Reduction\|Stimulant Harm Reduction]] for more information.

	==Interactions==		=== Interactions ===

	See the [[Drug combinations]] chart for more information.		See the [[Drug combinations]] chart for more information.

	= Chemistry and Pharmacology =		== Chemistry and Pharmacology ==

	==Chemistry==		=== Chemistry ===

	2,5-Dimethoxy-4-ethylphenethylamine is a colorless oil and analogue of mescaline. Similarly it is classified as a psychedelic phenethylamine. It shares the substituted amphetamine core found in the structure of many entactogens. Crystalline forms are obtained as the amine salt by reacting the free base with a mineral acid, typically HCl. It is soluble in both water and ethanol. Maximum concentration in H2O is reported at ~50mg/ml and it is said to be relatively stable in solution. A drop below normal ambient temperatures can cause particles to crystalize out.		2,5-Dimethoxy-4-ethylphenethylamine is a colorless oil and analogue of mescaline. Similarly it is classified as a psychedelic phenethylamine. It shares the substituted amphetamine core found in the structure of many entactogens. Crystalline forms are obtained as the amine salt by reacting the free base with a mineral acid, typically HCl. It is soluble in both water and ethanol. Maximum concentration in H2O is reported at ~50mg/ml and it is said to be relatively stable in solution. A drop below normal ambient temperatures can cause particles to crystalize out.
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	A full write up on Shulgin's synthesis for 2C-E can be found [https://www.erowid.org/library/books_online/pihkal/pihkal024.shtml here].		A full write up on Shulgin's synthesis for 2C-E can be found [https://www.erowid.org/library/books_online/pihkal/pihkal024.shtml here].

	==Pharmacology==		=== Pharmacology ===

	Like most psychedelic drugs, 2C-E is a 5-HT2a Agonist; from that, we can presume the concurrent or pre-administration of SSRIs may reduce the effects of 2C-E. 2C-E is one of the most potent of the 2C-X family, behind only 2C-P and 2C-T-4. The 2C-X family, specifically, 2C-E, 2C-I, and 2C-C all stimulated G protein binding, suggesting more of an activity similar to tryptamines such as 5-MeO-DMT and, interestingly, DPT. G Proteins are membrane proteins that effectively mediate interaction between hormone receptors and enzymes responsible for changes of metabolism as a result of hormonal changes.		Like most psychedelic drugs, 2C-E is a 5-HT2a Agonist; from that, we can presume the concurrent or pre-administration of SSRIs may reduce the effects of 2C-E. 2C-E is one of the most potent of the 2C-X family, behind only 2C-P and 2C-T-4. The 2C-X family, specifically, 2C-E, 2C-I, and 2C-C all stimulated G protein binding, suggesting more of an activity similar to tryptamines such as 5-MeO-DMT and, interestingly, DPT. G Proteins are membrane proteins that effectively mediate interaction between hormone receptors and enzymes responsible for changes of metabolism as a result of hormonal changes.
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	In rats, Stage I metabolism involved deamination and O-Demthylation, which are related to the Monoamine oxidase (MAO) and cytochrome P450 (CYP) enzymes. For virtually all the 2C’s, (B,I,D,E,T-2, and T-7), MAO-A and MAO-B were reacted upon; interestingly, ½ of the molecules in Shulgin’s Magical Half Dozen (2C-E, 2C-T-2, 2C-T-7, with the addition of 2C-D) also act to a small extent on the CYP2D6 enzyme. Because of the commonality of these receptors, the 2C-X family is likely to be more reactive with other concurrently administered chemicals.		In rats, Stage I metabolism involved deamination and O-Demthylation, which are related to the Monoamine oxidase (MAO) and cytochrome P450 (CYP) enzymes. For virtually all the 2C’s, (B,I,D,E,T-2, and T-7), MAO-A and MAO-B were reacted upon; interestingly, ½ of the molecules in Shulgin’s Magical Half Dozen (2C-E, 2C-T-2, 2C-T-7, with the addition of 2C-D) also act to a small extent on the CYP2D6 enzyme. Because of the commonality of these receptors, the 2C-X family is likely to be more reactive with other concurrently administered chemicals.

	== LD50 ==		=== LD50 ===

	The LD50 in humans is not currently known. Use caution when exploring high doses of this compound.		The LD50 in humans is not currently known. Use caution when exploring high doses of this compound.

	= Legal status =		== Legal status ==

	* In Australia, 2C-E was added to the 'Dangerous Drugs' list of the 'Drugs Misuse Amendment Act 2008.		* In Australia, 2C-E was added to the 'Dangerous Drugs' list of the 'Drugs Misuse Amendment Act 2008.
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	* In the USA, 2C-E is a Schedule I substance under the FDA Safety and Innovation act of 2012, and is illegal to possess, distribute or manufacture.		* In the USA, 2C-E is a Schedule I substance under the FDA Safety and Innovation act of 2012, and is illegal to possess, distribute or manufacture.

	= Links =		== Links ==

	* [https://www.erowid.org/chemicals/2ce/ Erowid]		* [https://www.erowid.org/chemicals/2ce/ Erowid]
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	[[Category:Stimulant]]		[[Category:Stimulant]]

	[[Category:Psychedelic]]		[[Category:Psychedelic]]

	[[Category:Drugs]]		[[Category:Drugs]]
	[[Category:Research Chemical]]		[[Category:Research Chemical]]

Sleep at 20:17, 23 December 2014

2014-12-23T20:17:29Z

← Older revision		Revision as of 15:17, 23 December 2014
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	[[Category:Drugs]]		[[Category:Drugs]]
			[[Category:Research Chemical]]

Krill: /* Chemistry */

2014-12-15T13:52:29Z

Chemistry

← Older revision		Revision as of 08:52, 15 December 2014
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	2,5-Dimethoxy-4-ethylphenethylamine is a colorless oil and analogue of mescaline. Similarly it is classified as a psychedelic phenethylamine. It shares the substituted amphetamine core found in the structure of many entactogens. Crystalline forms are obtained as the amine salt by reacting the free base with a mineral acid, typically HCl. It is soluble in both water and ethanol. Maximum concentration in H2O is reported at ~50mg/ml and it is said to be relatively stable in solution. A drop below normal ambient temperatures can cause particles to crystalize out.		2,5-Dimethoxy-4-ethylphenethylamine is a colorless oil and analogue of mescaline. Similarly it is classified as a psychedelic phenethylamine. It shares the substituted amphetamine core found in the structure of many entactogens. Crystalline forms are obtained as the amine salt by reacting the free base with a mineral acid, typically HCl. It is soluble in both water and ethanol. Maximum concentration in H2O is reported at ~50mg/ml and it is said to be relatively stable in solution. A drop below normal ambient temperatures can cause particles to crystalize out.

	Shulgin does not report an exact boiling point for the free base, stating only that during one synthesis the fraction boiling between 90-100 °C at 0.25 mmHg pressure was collected and converted to the hydrochloride salt. Shulgin reports the melting point of the hydrochloride salt as 208.5-210.5 °C~~. Similarly it is classified as a psychedelic phenethylamine. It shares the substituted amphetamine core found in the structure of many entactogens~~.		Shulgin does not report an exact boiling point for the free base, stating only that during one synthesis the fraction boiling between 90-100 °C at 0.25 mmHg pressure was collected and converted to the hydrochloride salt. Shulgin reports the melting point of the hydrochloride salt as 208.5-210.5 °C.

	A full write up on Shulgin's synthesis for 2C-E can be found [https://www.erowid.org/library/books_online/pihkal/pihkal024.shtml here].		A full write up on Shulgin's synthesis for 2C-E can be found [https://www.erowid.org/library/books_online/pihkal/pihkal024.shtml here].

Sevenforall at 21:27, 3 November 2014

2014-11-03T21:27:53Z

← Older revision		Revision as of 16:27, 3 November 2014
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	[[File:2ce.jpg\|thumb\|~~200px~~\|Vial of 2C-E with powder]]		[[File:2ce.jpg\|thumb\|150px\|Vial of 2C-E with powder]]

	2C-E is a chemical of the [[2C-X]] series which is characterised by its particularly intense visuals and higher potency when compared with other members of the family.		2C-E is a chemical of the [[2C-X]] series which is characterised by its particularly intense visuals and higher potency when compared with other members of the family.