2C-B

2017-06-30T16:12:50Z

PinkDino: /* Negative */

[[File:2cb.jpg|thumb|150px|2C-B vial and powder]]

'''2C-B''' is a [[Psychedelics|psychedelic]] drug of the [[2C-X|2C-X family]].
Effects are often described as being more easily managed than other psychedelics; it is often compared to a mixture of a LSD and MDMA.
2C-B is also known for the strong body component of its effects which are alternately described as pleasurable energy or a 'sense of being in the body,' and by others as an unpleasant 'buzzing' or body-load, which is mostly occurring during onset. Users also report open eye visuals in the form of colour distortions, melting like hallucinations, and other minor visual psychedelic effects.

== History ==
2C-B was first synthesized in 1974 by Alexander Shulgin, and it first saw use among the psychiatric community as an aid during therapy. It was considered one of the best drugs for this purpose because of its short duration, relative absence of side effects, and comparably mild nature. Shortly after becoming popular in the medical community, it became popular recreationally. 2C-B was first sold commercially as an aphrodisiac under the trade name "Eros", which was manufactured by the German pharmaceutical company Drittewelle. From many years after it was available as tablets in Dutch smart shops under the name "Nexus".

== Dosage ==
'''NOTE: DO NOT TAKE THE BELOW DOSING INFORMATION AS A KNOW ALL, PLEASE TAKE CAUTION, AND REMEMBER THAT YOU CAN ALWAYS TAKE MORE, BUT NEVER LESS.'''

{{#tdose: 2cb }}

== Duration ==

{| class="wikitable"
|+ Oral
|-
| Onset || 20-75 minutes
|-
| Total || 4-8 hours
|}

{| class="wikitable"
|+ Insufflated
|-
| Onset || 1-15 minutes
|-
| Total || 4-8 hours
|}

{| class="wikitable"
|+ Rectal
|-
| Onset || 5-20 minutes
|-
| Total || 4-8 hours
|}

== Effects ==
=== Positive ===

* Euphoria

* Giggling

* Empathy

* Personal Insight

* Enhanced Colours

* Closed and Open Eye Visuals

* Enhanced Tactile Sensation

=== Neutral ===

* Decreased Appetite

* Pupil Dilation

* Time Dilation

=== Negative ===

* Restlessness

* Sweating/Chills

* Nausea

* Insomnia

* Muscle Tension

* Confusion

*Vasoconstriction

== Aliases ==

* Bees

* Nexus

== Chemistry and Pharmacology ==
Systematic name: 2-(4-bromo-2,5-dimethoxyphenyl)ethanamine

Unlike most hallucinogens, 2C-B has been shown to be a low efficacy serotonin 5-HT2A receptor partial agonist or even full antagonist. This suggests that the 5-HT2C receptor is primarily responsible for mediating the effects experienced by users of 2C-B, although functional antagonism of 5-HT2A or activation of the 5-HT2A-coupled phospholipase D pathway may also play a role. The rank order of receptorantagonist potency for this family of drugs is 2C-I > 2C-B > 2C-D > 2C-H.

Research suggests that 2C-B increases dopamine levels in the brains of rats, which may contribute to its psychoactivity.

== Harm Reduction ==

2C-B is known as one of the safer psychedelics, with several reported cases of users far exceeding commonly used dosing limits without lasting adverse physical effects. It is also observed to have a low addiction potential. It is a stimulating psychedelic, and therefore it's important to remain hydrated. Refer to [[Psychedelics#Harm_Reduction|Psychedelic Harm Reduction]] for more information.

Do not take heroic doses thinking that 2C-B is one of the "safer psychedelics".

=== Interactions ===

2C-B increases dopamine levels and also has an effect on serotonin. Therefore, 2C-B may react negatively with serotonic drugs like anti-depressants and tramadol.

== Legal Status ==
Internationally, 2C-B is a Schedule II drug under the Convention on Psychotropic Substances. In the Netherlands, 2C-B became a list I substance of the Opium Law despite no health incidents occurring. Following the ban, other phenethylamines were sold in place of 2C-B until the Netherlands became the first country in the world to ban 2C-I, 2C-T-2 and 2C-T-7 alongside 2C-B.

* UK: Class A (Along with all the others in the [[2C-X|2C-X family]]. (Illegal to produce, supply, or possess.))

* United States: [http://www.justice.gov/dea/druginfo/ds.shtml Schedule I] (Illegal to produce, supply, or possess.)

== Links ==

* [https://en.wikipedia.org/wiki/2C-B Wikipedia]
* [https://www.erowid.org/chemicals/2cb/2cb.shtml 2C-B Erowid Vault]

[[Category:Drugs]]
[[Category:Psychedelic]]

LSD

2017-05-05T00:42:53Z

PinkDino: /* Negative */

[[File:Lsd_bottle.jpg|thumb|left]]

'''Lysergic acid diethylamide''', abbreviated LSD or LSD-25, also known as lysergide (INN) and colloquially as '''acid''', is a semisynthetic psychedelic drug of the ergoline family, well known for its psychological effects which can include altered thinking processes, closed and open-eyed visuals, synesthesia, an altered sense of time and spiritual experiences, as well as for its key role in 1960s counterculture. It is used mainly as an entheogen, recreational drug, and as an agent in psychedelic therapy. LSD is non-addictive, is not known to cause brain damage, and has extremely low toxicity relative to dose. However, acute adverse psychiatric reactions such as anxiety, paranoia, and delusions are possible.
LSD is the best known and most researched psychedelic. It is the standard against which all other psychedelics are compared. It is active at extremely low doses and is most commonly available on blotter or in liquid form.

== History ==
First synthesized by Albert Hofmann on November 16, 1938, LSD went on to become a staple of the psychedelic world and the centerpiece of the 1960s counterculture.
On April 19, 1943, Hofmann returned to investigate LSD further and ingested 250 micrograms of LSD. Hofmann believed this dose to have a minuscule, threshold effect. He rode his bicycle home and later wrote that, "... little by little I could begin to enjoy the unprecedented colors and plays of shapes that persisted behind my closed eyes. Kaleidoscopic, fantastic images surged in on me, alternating, variegated, opening and then closing themselves in circles and spirals, exploding in colored fountains, rearranging and hybridizing themselves in constant flux ..." This day in history later became known as Bicycle Day and is celebrated by LSD enthusiasts as the world's first LSD trip.

== Dosage ==
{{#tdose: lsd}}

== Duration ==

Note: Duration can be significantly longer with higher doses.

{| class="wikitable"
|+ Oral
|-
| Onset || 30-120 minutes
|-
| Total || 8-12 hours
|}

== Effects ==

=== Positive ===
* Mood lift, euphoria, sense of well being
* Closed and open eye visuals, including the saturation of colors, tracers, etc.

[[File:Lsdpatterns.png|thumb|500px|An example of visual effects on LSD]]

* Enhanced audio/tactile senses
* Increase in associative & creative thinking; introspection
* At high doses, feeling of 'oneness' with everything; ego death

=== Neutral ===

* Racing thoughts, thought loops
* Extreme pupil dilation; increased sensitivity to light
* Inability to focus
* Slight increase in body temperature and heart rate
* Time dilation; seconds feel like minutes, minutes like hours

=== Negative ===

* Tension
* Anxiety, restlessness, confusion
* Insomnia
* Nausea
* Dizziness
* Vasoconstriction

=== After effects ===

User may feel "out of it" and generally off the day after, esp. with larger doses. Residual euphoria and a "ready to take on the world" feeling may persist. No bodily harm from recreational doses of LSD, though mental effects from long term chronic use can be negative in some people.

== Harm Reduction ==

LSD is regarded as being an extremely safe psychedelic, being almost impossible to overdose on. However, although extraordinarily uncommon, a few cases have been reported in the medical literature of dangerous overheating following ingestion of large amounts of LSD, including one non-fatal case that brought the patient's body temperature to over 106°F (41°C). LSD may also cause dangerous physiological and psychological reactions when used in conjunction with lithium or tricyclic antidepressants.

See [[Psychedelics#Harm_Reduction|Psychedelic Harm Reduction]] for general information.

== Chemistry and Pharmacology ==
Chemical name: 9,10-Didehydro-N,N-diethyl-6-methylergoline-8ß-carboxamide

The mental effects of LSD can be rapidly reversed by the IM administration of 50 mg chlorpromazine.

=== LD50 ===

The LD50 has not been determined, but some estimates suggest doses higher than 10mg (10,000 µg) may be fatal

=== Reactivity ===

Stable for moderate periods of time under normal temperatures and pressures. Thermal decomposition products of LSD when stored in massive quantities may include dangerous amounts of toxic oxides, carbon, and nitrogen. Long-term storage of LSD should be done by limiting exposure to heat, light, and air; eg. wrapped in aluminium foil, vacuum sealed, and placed in a freezer or refrigerator.

=== Polymerization ===

Hazardous polymerization has not been reported to occur under normal temperatures and pressures.

== Legal status ==

LSD is illegal to possess for recreational purposes in most nations. This includes the US, Canada, Mexico, Finland, Germany, Greece, Italy, the Netherlands, Belgium, Sweden, New Zealand, Australia, Norway, Portugal, Russia, UK, and Brazil.

Some exceptions are made in nations where it is used in legitimate research, such as Russia. A license is required.

== Links ==

* [http://www.erowid.org/chemicals/lsd/lsd.shtml Erowid]
* [https://en.wikipedia.org/wiki/LSD Wikipedia]
* [http://www.maps.org/research-archive/w3pb/2008/2008_Passie_23067_1.pdf The Pharmacology of Lysergic Acid Diethylamide: A Review]

[[Category:Psychedelic]]
[[Category:Drugs]]

TripSit Wiki - User contributions [en]

2C-B

LSD