https://wiki.tripsit.me/api.php?action=feedcontributions&feedformat=atom&user=Denniskombucha 2026-04-16T00:05:28Z User contributions MediaWiki 1.44.0 https://wiki.tripsit.me/index.php?title=Terminology&diff=3212 2014-07-21T07:54:00Z

<p>Denniskombucha: </p> <hr /> <div>;MXE<br /> :Methoxetamine<br /> <br /> ;Agonist<br /> :A substance that initiates a physiological response when combined with a receptor.<br /> <br /> ;DRI<br /> :Dopamine Reuptake Inhibitor<br /> <br /> ;SSRI<br /> :Selective Serotonin Reuptake Inhibitor<br /> <br /> ;NMDA<br /> :N-methyl-D-aspartate receptor<br /> <br /> ;TAAR<br /> :Trace amine-associated receptor</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Terminology&diff=3210 2014-07-21T07:51:23Z

<p>Denniskombucha: </p> <hr /> <div>;MXE<br /> :Methoxetamine<br /> <br /> ;Agonist<br /> :A substance that initiates a physiological response when combined with a receptor.<br /> <br /> ;DRI<br /> :Dopamine Reuptake Inhibitor</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Glossary&diff=3197 2014-07-21T06:42:16Z

<p>Denniskombucha: /* Monoamine Oxidase */</p> <hr /> <div><br /> =='''Agonist'''==<br /> A substance that initiates a physiological response when combined with a receptor.<br /> <br /> =='''Antagonist'''==<br /> A substance that interferes with or inhibits the physiological action of another.<br /> <br /> =='''Cannabinoid'''==<br /> Chemicals produced naturally that bind to cannabinoid receptors. They are involved in a variety of mental and physical processes, including pain regulation, food intake, and reward.<br /> <br /> =='''Cathinone'''==<br /> Cathinone, or Benzoylethanamine is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine and other amphetamines. Cathinone differs from amphetamine by possessing a ketone oxygen atom on the β position of the side chain.<br /> <br /> =='''Chirality'''==<br /> The term chiral describes an object, especially a molecule, which has or produces a non-superimposeable mirror image of itself.<br /> <br /> =='''Dopamine'''==<br /> A neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system.<br /> <br /> =='''Enantiomer'''==<br /> One of two stereoisomers that are mirror images of each other that are non-superposable (not identical). Think of it like the left and right hand, which are identical aside from orientation.<br /> <br /> =='''First pass metabolism'''==<br /> First pass metabolism is the process in which the liver starts to break down drugs before they reach systemic circulation. Different ROA's including insufflation are used to bypass this process to increase potency.<br /> <br /> =='''GABA'''==<br /> Gamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter.<br /> <br /> =='''GABA receptor'''==<br /> The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA).<br /> <br /> =='''Inverse agonist'''==<br /> an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.<br /> <br /> =='''Isomer'''==<br /> Each of two or more compounds with the same formula but a different arrangement of atoms in the molecule and different properties.<br /> <br /> =='''MAOI'''==<br /> Monoamine oxidase inhibitor any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate.<br /> <br /> =='''Monoamine Oxidase'''==<br /> An enzyme that catalyzes the metabolism of many drugs (e.g., DMT, dopamine and serotonin).<br /> <br /> =='''NMDA receptor'''==<br /> A glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function.<br /> <br /> =='''Nootropics'''==<br /> These are a class of drugs that work by increasing levels of either/or neurotransmitters, enzymes, hormones, oxygen supply, and/or stimulating nerve growth. They are generaly neuroprotective, and extremely non-toxic.<br /> <br /> =='''Norepinephrine'''==<br /> Norepinephrine, or noradrenaline, is a catecholamine with multiple roles including as a hormone and a neurotransmitter.<br /> <br /> =='''Phenethylamine'''==<br /> Phenethylamine (PEA) is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. In the mammalian central nervous system, phenethylamine is believed to function as a neuromodulator or neurotransmitter.<br /> <br /> =='''Phenethylamine (substituted)'''==<br /> The substituted phenethylamines are a family of chemical compounds that contain the 2-phenylethylamine chemical structure and also have additional modifications at the phenyl ring, sidechain, and/or amino group (i.e. MDMA).<br /> <br /> =='''Re-uptake inhibitor'''==<br /> Also known as a transporter blocker, is a drug which inhibits the transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> =='''Releaser'''==<br /> A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> =='''Research Chemical'''==<br /> Designer drugs, a term used to describe drugs which are created (or marketed, if they had already existed) to get around existing drug laws, usually by modifying the molecular structures of existing drugs to varying degrees, or less commonly by finding drugs with entirely different chemical.<br /> <br /> =='''ROA'''==<br /> Common abbreviation for Route Of Administration, used to describe the various different methods of ingesting drugs, including oral, insufflation, sublingual/buccal, rectal, intramuscular (IM) and intravenous (IV) injection.<br /> <br /> =='''Inverse agonist '''==<br /> An inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist (i.e. Naloxone).<br /> <br /> =='''Serotonin (5-HT)'''==<br /> A monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being.<br /> <br /> =='''Tryptamine'''==<br /> Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived.</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Methamphetamine&diff=3196 2014-07-21T06:36:28Z

<p>Denniskombucha: </p> <hr /> <div>[[File:Crystal Meth.jpg|250px|right]]<br /> <br /> Methamphetamine is a strong physical and mental stimulant. It is legally prescribed as a treatment for ADD under the brand name Desoxyn, for both children and adults. Recreationally, methamphetamine is used to increase sexual, lift the mood, and increase energy, allowing some users to engage in sexual activity continuously for several days straight. Methamphetamine production is a relatively simple process, especially when compared to many other recreational drugs which has contributed to its widespread use. It is frequently reported on in the media when home meth-producing labs are busted.<br /> <br /> Methamphetamine exists as two [[Glossary#Enantiomer|enantiomers]], dextrorotary and levorotary. Dextromethamphetamine is a stronger central nervous system(CNS) stimulant than levomethamphetamine; however, both are addictive and produce the same toxicity symptoms at high doses. Methamphetamine may be sold illegally, either as pure dextromethamphetamine or in an equal parts mixture of the right and left handed molecules (i.e., 50% levomethamphetamine and 50% dextromethamphetamine). Both dextromethamphetamine and racemic methamphetamine are schedule II controlled substances in the United States. Similarly, the production, distribution, sale, and possession of methamphetamine is restricted or illegal in many other countries due to its placement in schedule II of the United Nations Convention on Psychotropic Substancestreaty. In contrast, levomethamphetamine is an over-the-counter drug in the United States.<br /> <br /> == History ==<br /> Amphetamine, discovered before methamphetamine, was first synthesized in 1887 in Germany by Romanian chemist Lazăr Edeleanu who named it phenylisopropylamine. Shortly after, methamphetamine was synthesized from ephedrine in 1893 by Japanesechemist Nagai Nagayoshi. Three decades later, in 1919, methamphetamine hydrochloride was synthesized by pharmacologist Akira Ogata via reduction of ephedrine using red phosphorus and iodine. During World War II, methamphetamine was used extensively by the Axis forces for its stimulant effects. Obetrol, patented by Obetrol Pharmaceuticals in the 1950s and indicated for treatment of obesity, was one of the first brands of pharmaceutical methamphetamine products. Due to the psychological and stimulant effects of methamphetamine, Obetrol became a popular diet pill in America in the 1950s and 1960s. Eventually, as the addictive properties of the drug became known, governments began to strictly regulate the production and distribution of methamphetamine. For example, during the early 1970s in the United States, methamphetamine became a schedule II controlled substance under the Controlled Substances Act. Currently, methamphetamine is sold under the trade name Desoxyn, trademarked by the Danish pharmaceutical company Lundbeck. As of January 2013, the Desoxyn trademark had been sold to Italian pharmaceutical company Recordati.<br /> <br /> = Dosage =<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | Light || 5-15mg<br /> |-<br /> | Common || 10-30mg<br /> |-<br /> | Strong || 20-60mg<br /> |-<br /> | Heavy || 40-150mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Insufflated<br /> |-<br /> | Light || 5-15mg<br /> |-<br /> | Common || 10-40mg<br /> |-<br /> | Strong || 30-60mg<br /> |-<br /> | Heavy || 50mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Smoked<br /> |-<br /> | Light || 5-10mg<br /> |-<br /> | Common || 10-20mg<br /> |-<br /> | Strong || 30-60mg<br /> |-<br /> | Heavy || 50mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Intravenous<br /> |-<br /> | Light || 5-10mg<br /> |-<br /> | Common || 10-40mg<br /> |-<br /> | Strong || 30-60mg<br /> |-<br /> | Heavy || 50-100mg<br /> |}<br /> <br /> = Duration =<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | Onset || 20-70 minutes<br /> |-<br /> | Total || 3-5 hours<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Insufflated<br /> |-<br /> | Onset || 5-10 minutes<br /> |-<br /> | Total || 2-4 hours<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Smoked<br /> |-<br /> | Onset || 0-2 minutes<br /> |-<br /> | Total || 1-3 hours<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Intravenous<br /> |-<br /> | Onset || 0-2 minutes<br /> |-<br /> | Total || 4-8 hours<br /> |}<br /> <br /> = Effects =<br /> == Positive ==<br /> <br /> *Increased energy, alertness<br /> <br /> *Sleep suppression<br /> <br /> *Increased sociability<br /> <br /> *Mood elevation<br /> <br /> *Increased libido<br /> <br /> == Neutral ==<br /> <br /> *Excessive talking<br /> <br /> *Decreased appetite <br /> <br /> *Sweating<br /> <br /> *Dilated pupils<br /> <br /> == Negative ==<br /> <br /> *Weight loss<br /> <br /> *Disturbed sleep patterns, Insomnia<br /> <br /> *Bruxia<br /> <br /> *Drying of oral mucosa<br /> <br /> *Loss of appetite<br /> <br /> *Visual and auditory hallucinations<br /> <br /> *Itchiness<br /> <br /> *Aggressiveness<br /> <br /> *Moodiness, Irritability, Anxiety<br /> <br /> *Increased heart rate, Irregular heart rhythm<br /> <br /> *Excessive sweating, Dehydration<br /> <br /> *Fatal kidney disorder<br /> <br /> *Possible brain damage<br /> <br /> *Liver damage<br /> <br /> = Harm Reduction =<br /> When dealing with methamphetamine it's important to remember that a large number of the harms come not from the drug itself, but from the behaviors the drug causes individuals to exhibit. Loss of sleep, poor nutrition, and poor self care are the cause of many of the negative effects. <br /> <br /> *Methamphetamine lasts for a long time and will impair sleep. Dose early in the day and do not redose to avoid sleep disruption.<br /> <br /> *Oral roa has less redose compulsion than other routes such as vaporization. <br /> <br /> *It is important to eat and stay hydrated, even if you do not feel the need for food. Even if you are not feeling like eating you can generally have some fruit or a bowl of cereal or yogurt with granola. <br /> <br /> *It is important to keep up on your self-care. &quot;Meth mouth&quot; is caused by poor oral hygiene combined with the habit of users to sip sugary beverages to relieve dry mouth symptoms. Use water and not soda to relieve dry mouth. Remember to brush your teeth after eating or consuming any caloric beverages.<br /> <br /> = Chemistry and Pharmacology =<br /> [[File:Meth molecule.jpg|150px|right]]<br /> <br /> Systematic name: N-methyl-1-phenylpropan-2-amine<br /> <br /> At room temperature, the free base of methamphetamine is a clear and colorless liquid with an odor characteristic of geranium leaves. It is soluble in diethyl ether and ethanol as well as miscible with chloroform. In contrast, the methampetamine hydrochloride salt is odorless with a bitter taste. It has a melting point between 170 to 175 °C (338 to 347 °F) and, at room temperature, occurs as white crystals or a white crystalline powder. The hydrochloride salt is also freely soluble in alcohol and water.<br /> <br /> Powder methamphetamine is the hydrochloride salt form which is strongly hygroscopic (absorbs water from the air quickly). The HCl salt is smokable as is. Crystal meth &quot;Crystal Meth&quot; or &quot;Ice&quot; refer to methamphetamine grown into crystals. Though many people believe that Crystal Meth is the freebase form of methamphetamie HCl, this is not true. Methamphetamine is smokable in its normal HCL form, but taking the time to grow it into crystals makes it easier to smoke. Meth in visible crystals (rather than powder) is likely to be relatively pure as it is difficult to grow crystals from impure material. Methamphetamine freebase is an oil and is uncommon on the street.<br /> <br /> = Links=<br /> <br /> [https://en.wikipedia.org/wiki/Methamphetamine Wikipedia]<br /> <br /> [https://www.erowid.org/chemicals/meth/meth.shtml Erowid]<br /> <br /> [http://reddit.com/r/Drugs/wiki/methamphetamine /r/Drugs Wiki]<br /> <br /> [http://science.howstuffworks.com/meth3.htm howstuffworks]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Stimulant]]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Methamphetamine&diff=3195 2014-07-21T06:35:25Z

<p>Denniskombucha: </p> <hr /> <div>[[File:Crystal Meth.jpg|250px|right]]<br /> <br /> Methamphetamine is a strong physical and mental stimulant. It is legally prescribed as a treatment for ADD under the brand name Desoxyn, for both children and adults. Recreationally, methamphetamine is used to increase sexual, lift the mood, and increase energy, allowing some users to engage in sexual activity continuously for several days straight. Methamphetamine production is a relatively simple process, especially when compared to many other recreational drugs which has contributed to its widespread use. It is frequently reported on in the media when home meth-producing labs are busted.<br /> <br /> Methamphetamine exists as two [[Glossary#Enantiomers|enantiomers]], dextrorotary and levorotary. Dextromethamphetamine is a stronger central nervous system(CNS) stimulant than levomethamphetamine; however, both are addictive and produce the same toxicity symptoms at high doses. Methamphetamine may be sold illegally, either as pure dextromethamphetamine or in an equal parts mixture of the right and left handed molecules (i.e., 50% levomethamphetamine and 50% dextromethamphetamine). Both dextromethamphetamine and racemic methamphetamine are schedule II controlled substances in the United States. Similarly, the production, distribution, sale, and possession of methamphetamine is restricted or illegal in many other countries due to its placement in schedule II of the United Nations Convention on Psychotropic Substancestreaty. In contrast, levomethamphetamine is an over-the-counter drug in the United States.<br /> <br /> == History ==<br /> Amphetamine, discovered before methamphetamine, was first synthesized in 1887 in Germany by Romanian chemist Lazăr Edeleanu who named it phenylisopropylamine. Shortly after, methamphetamine was synthesized from ephedrine in 1893 by Japanesechemist Nagai Nagayoshi. Three decades later, in 1919, methamphetamine hydrochloride was synthesized by pharmacologist Akira Ogata via reduction of ephedrine using red phosphorus and iodine. During World War II, methamphetamine was used extensively by the Axis forces for its stimulant effects. Obetrol, patented by Obetrol Pharmaceuticals in the 1950s and indicated for treatment of obesity, was one of the first brands of pharmaceutical methamphetamine products. Due to the psychological and stimulant effects of methamphetamine, Obetrol became a popular diet pill in America in the 1950s and 1960s. Eventually, as the addictive properties of the drug became known, governments began to strictly regulate the production and distribution of methamphetamine. For example, during the early 1970s in the United States, methamphetamine became a schedule II controlled substance under the Controlled Substances Act. Currently, methamphetamine is sold under the trade name Desoxyn, trademarked by the Danish pharmaceutical company Lundbeck. As of January 2013, the Desoxyn trademark had been sold to Italian pharmaceutical company Recordati.<br /> <br /> = Dosage =<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | Light || 5-15mg<br /> |-<br /> | Common || 10-30mg<br /> |-<br /> | Strong || 20-60mg<br /> |-<br /> | Heavy || 40-150mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Insufflated<br /> |-<br /> | Light || 5-15mg<br /> |-<br /> | Common || 10-40mg<br /> |-<br /> | Strong || 30-60mg<br /> |-<br /> | Heavy || 50mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Smoked<br /> |-<br /> | Light || 5-10mg<br /> |-<br /> | Common || 10-20mg<br /> |-<br /> | Strong || 30-60mg<br /> |-<br /> | Heavy || 50mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Intravenous<br /> |-<br /> | Light || 5-10mg<br /> |-<br /> | Common || 10-40mg<br /> |-<br /> | Strong || 30-60mg<br /> |-<br /> | Heavy || 50-100mg<br /> |}<br /> <br /> = Duration =<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | Onset || 20-70 minutes<br /> |-<br /> | Total || 3-5 hours<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Insufflated<br /> |-<br /> | Onset || 5-10 minutes<br /> |-<br /> | Total || 2-4 hours<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Smoked<br /> |-<br /> | Onset || 0-2 minutes<br /> |-<br /> | Total || 1-3 hours<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Intravenous<br /> |-<br /> | Onset || 0-2 minutes<br /> |-<br /> | Total || 4-8 hours<br /> |}<br /> <br /> = Effects =<br /> == Positive ==<br /> <br /> *Increased energy, alertness<br /> <br /> *Sleep suppression<br /> <br /> *Increased sociability<br /> <br /> *Mood elevation<br /> <br /> *Increased libido<br /> <br /> == Neutral ==<br /> <br /> *Excessive talking<br /> <br /> *Decreased appetite <br /> <br /> *Sweating<br /> <br /> *Dilated pupils<br /> <br /> == Negative ==<br /> <br /> *Weight loss<br /> <br /> *Disturbed sleep patterns, Insomnia<br /> <br /> *Bruxia<br /> <br /> *Drying of oral mucosa<br /> <br /> *Loss of appetite<br /> <br /> *Visual and auditory hallucinations<br /> <br /> *Itchiness<br /> <br /> *Aggressiveness<br /> <br /> *Moodiness, Irritability, Anxiety<br /> <br /> *Increased heart rate, Irregular heart rhythm<br /> <br /> *Excessive sweating, Dehydration<br /> <br /> *Fatal kidney disorder<br /> <br /> *Possible brain damage<br /> <br /> *Liver damage<br /> <br /> = Harm Reduction =<br /> When dealing with methamphetamine it's important to remember that a large number of the harms come not from the drug itself, but from the behaviors the drug causes individuals to exhibit. Loss of sleep, poor nutrition, and poor self care are the cause of many of the negative effects. <br /> <br /> *Methamphetamine lasts for a long time and will impair sleep. Dose early in the day and do not redose to avoid sleep disruption.<br /> <br /> *Oral roa has less redose compulsion than other routes such as vaporization. <br /> <br /> *It is important to eat and stay hydrated, even if you do not feel the need for food. Even if you are not feeling like eating you can generally have some fruit or a bowl of cereal or yogurt with granola. <br /> <br /> *It is important to keep up on your self-care. &quot;Meth mouth&quot; is caused by poor oral hygiene combined with the habit of users to sip sugary beverages to relieve dry mouth symptoms. Use water and not soda to relieve dry mouth. Remember to brush your teeth after eating or consuming any caloric beverages.<br /> <br /> = Chemistry and Pharmacology =<br /> [[File:Meth molecule.jpg|150px|right]]<br /> <br /> Systematic name: N-methyl-1-phenylpropan-2-amine<br /> <br /> At room temperature, the free base of methamphetamine is a clear and colorless liquid with an odor characteristic of geranium leaves. It is soluble in diethyl ether and ethanol as well as miscible with chloroform. In contrast, the methampetamine hydrochloride salt is odorless with a bitter taste. It has a melting point between 170 to 175 °C (338 to 347 °F) and, at room temperature, occurs as white crystals or a white crystalline powder. The hydrochloride salt is also freely soluble in alcohol and water.<br /> <br /> Powder methamphetamine is the hydrochloride salt form which is strongly hygroscopic (absorbs water from the air quickly). The HCl salt is smokable as is. Crystal meth &quot;Crystal Meth&quot; or &quot;Ice&quot; refer to methamphetamine grown into crystals. Though many people believe that Crystal Meth is the freebase form of methamphetamie HCl, this is not true. Methamphetamine is smokable in its normal HCL form, but taking the time to grow it into crystals makes it easier to smoke. Meth in visible crystals (rather than powder) is likely to be relatively pure as it is difficult to grow crystals from impure material. Methamphetamine freebase is an oil and is uncommon on the street.<br /> <br /> = Links=<br /> <br /> [https://en.wikipedia.org/wiki/Methamphetamine Wikipedia]<br /> <br /> [https://www.erowid.org/chemicals/meth/meth.shtml Erowid]<br /> <br /> [http://reddit.com/r/Drugs/wiki/methamphetamine /r/Drugs Wiki]<br /> <br /> [http://science.howstuffworks.com/meth3.htm howstuffworks]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Stimulant]]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Glossary&diff=3194 2014-07-21T06:35:14Z

<p>Denniskombucha: /* Enantiomer= */</p> <hr /> <div><br /> =='''Agonist'''==<br /> A substance that initiates a physiological response when combined with a receptor.<br /> <br /> =='''Antagonist'''==<br /> A substance that interferes with or inhibits the physiological action of another.<br /> <br /> =='''Cannabinoid'''==<br /> Chemicals produced naturally that bind to cannabinoid receptors. They are involved in a variety of mental and physical processes, including pain regulation, food intake, and reward.<br /> <br /> =='''Cathinone'''==<br /> Cathinone, or Benzoylethanamine is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine and other amphetamines. Cathinone differs from amphetamine by possessing a ketone oxygen atom on the β position of the side chain.<br /> <br /> =='''Chirality'''==<br /> The term chiral describes an object, especially a molecule, which has or produces a non-superimposeable mirror image of itself.<br /> <br /> =='''Dopamine'''==<br /> A neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system.<br /> <br /> =='''Enantiomer'''==<br /> One of two stereoisomers that are mirror images of each other that are non-superposable (not identical). Think of it like the left and right hand, which are identical aside from orientation.<br /> <br /> =='''First pass metabolism'''==<br /> First pass metabolism is the process in which the liver starts to break down drugs before they reach systemic circulation. Different ROA's including insufflation are used to bypass this process to increase potency.<br /> <br /> =='''GABA'''==<br /> Gamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter.<br /> <br /> =='''GABA receptor'''==<br /> The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA).<br /> <br /> =='''Inverse agonist'''==<br /> an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.<br /> <br /> =='''Isomer'''==<br /> Each of two or more compounds with the same formula but a different arrangement of atoms in the molecule and different properties.<br /> <br /> =='''MAOI'''==<br /> Monoamine oxidase inhibitor any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate.<br /> <br /> =='''Monoamine Oxidase'''==<br /> An enzyme that catalyzes the metabolism of many drugs (e.g., DMT, dopamine and serotonin).<br /> <br /> =='''NMDA receptor''' A glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function.<br /> <br /> =='''Nootropics'''==<br /> These are a class of drugs that work by increasing levels of either/or neurotransmitters, enzymes, hormones, oxygen supply, and/or stimulating nerve growth. They are generaly neuroprotective, and extremely non-toxic.<br /> <br /> =='''Norepinephrine'''==<br /> Norepinephrine, or noradrenaline, is a catecholamine with multiple roles including as a hormone and a neurotransmitter.<br /> <br /> =='''Phenethylamine'''==<br /> Phenethylamine (PEA) is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. In the mammalian central nervous system, phenethylamine is believed to function as a neuromodulator or neurotransmitter.<br /> <br /> =='''Phenethylamine (substituted)'''==<br /> The substituted phenethylamines are a family of chemical compounds that contain the 2-phenylethylamine chemical structure and also have additional modifications at the phenyl ring, sidechain, and/or amino group (i.e. MDMA).<br /> <br /> =='''Re-uptake inhibitor'''==<br /> Also known as a transporter blocker, is a drug which inhibits the transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> =='''Releaser'''==<br /> A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> =='''Research Chemical'''==<br /> Designer drugs, a term used to describe drugs which are created (or marketed, if they had already existed) to get around existing drug laws, usually by modifying the molecular structures of existing drugs to varying degrees, or less commonly by finding drugs with entirely different chemical.<br /> <br /> =='''ROA'''==<br /> Common abbreviation for Route Of Administration, used to describe the various different methods of ingesting drugs, including oral, insufflation, sublingual/buccal, rectal, intramuscular (IM) and intravenous (IV) injection.<br /> <br /> =='''Inverse agonist '''==<br /> An inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist (i.e. Naloxone).<br /> <br /> =='''Serotonin (5-HT)'''==<br /> A monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being.<br /> <br /> =='''Tryptamine'''==<br /> Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived.</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Glossary&diff=3193 2014-07-21T06:33:37Z

<p>Denniskombucha: </p> <hr /> <div><br /> =='''Agonist'''==<br /> A substance that initiates a physiological response when combined with a receptor.<br /> <br /> =='''Antagonist'''==<br /> A substance that interferes with or inhibits the physiological action of another.<br /> <br /> =='''Cannabinoid'''==<br /> Chemicals produced naturally that bind to cannabinoid receptors. They are involved in a variety of mental and physical processes, including pain regulation, food intake, and reward.<br /> <br /> =='''Cathinone'''==<br /> Cathinone, or Benzoylethanamine is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine and other amphetamines. Cathinone differs from amphetamine by possessing a ketone oxygen atom on the β position of the side chain.<br /> <br /> =='''Chirality'''==<br /> The term chiral describes an object, especially a molecule, which has or produces a non-superimposeable mirror image of itself.<br /> <br /> =='''Dopamine'''==<br /> A neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system.<br /> <br /> =='''Enantiomer'''===<br /> One of two stereoisomers that are mirror images of each other that are non-superposable (not identical). Think of it like the left and right hand, which are identical aside from orientation.<br /> <br /> =='''First pass metabolism'''==<br /> First pass metabolism is the process in which the liver starts to break down drugs before they reach systemic circulation. Different ROA's including insufflation are used to bypass this process to increase potency.<br /> <br /> =='''GABA'''==<br /> Gamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter.<br /> <br /> =='''GABA receptor'''==<br /> The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA).<br /> <br /> =='''Inverse agonist'''==<br /> an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.<br /> <br /> =='''Isomer'''==<br /> Each of two or more compounds with the same formula but a different arrangement of atoms in the molecule and different properties.<br /> <br /> =='''MAOI'''==<br /> Monoamine oxidase inhibitor any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate.<br /> <br /> =='''Monoamine Oxidase'''==<br /> An enzyme that catalyzes the metabolism of many drugs (e.g., DMT, dopamine and serotonin).<br /> <br /> =='''NMDA receptor''' A glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function.<br /> <br /> =='''Nootropics'''==<br /> These are a class of drugs that work by increasing levels of either/or neurotransmitters, enzymes, hormones, oxygen supply, and/or stimulating nerve growth. They are generaly neuroprotective, and extremely non-toxic.<br /> <br /> =='''Norepinephrine'''==<br /> Norepinephrine, or noradrenaline, is a catecholamine with multiple roles including as a hormone and a neurotransmitter.<br /> <br /> =='''Phenethylamine'''==<br /> Phenethylamine (PEA) is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. In the mammalian central nervous system, phenethylamine is believed to function as a neuromodulator or neurotransmitter.<br /> <br /> =='''Phenethylamine (substituted)'''==<br /> The substituted phenethylamines are a family of chemical compounds that contain the 2-phenylethylamine chemical structure and also have additional modifications at the phenyl ring, sidechain, and/or amino group (i.e. MDMA).<br /> <br /> =='''Re-uptake inhibitor'''==<br /> Also known as a transporter blocker, is a drug which inhibits the transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> =='''Releaser'''==<br /> A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> =='''Research Chemical'''==<br /> Designer drugs, a term used to describe drugs which are created (or marketed, if they had already existed) to get around existing drug laws, usually by modifying the molecular structures of existing drugs to varying degrees, or less commonly by finding drugs with entirely different chemical.<br /> <br /> =='''ROA'''==<br /> Common abbreviation for Route Of Administration, used to describe the various different methods of ingesting drugs, including oral, insufflation, sublingual/buccal, rectal, intramuscular (IM) and intravenous (IV) injection.<br /> <br /> =='''Inverse agonist '''==<br /> An inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist (i.e. Naloxone).<br /> <br /> =='''Serotonin (5-HT)'''==<br /> A monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being.<br /> <br /> =='''Tryptamine'''==<br /> Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived.</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Glossary&diff=3192 2014-07-21T06:28:49Z

<p>Denniskombucha: </p> <hr /> <div><br /> =='''Agonist'''==<br /> A substance that initiates a physiological response when combined with a receptor.<br /> <br /> =='''Antagonist'''==<br /> A substance that interferes with or inhibits the physiological action of another.<br /> <br /> =='''Cannabinoid'''==<br /> Chemicals produced naturally that bind to cannabinoid receptors. They are involved in a variety of mental and physical processes, including pain regulation, food intake, and reward.<br /> <br /> =='''Cathinone'''==<br /> Cathinone, or Benzoylethanamine is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine and other amphetamines. Cathinone differs from amphetamine by possessing a ketone oxygen atom on the β position of the side chain.<br /> <br /> =='''Chirality'''==<br /> The term chiral describes an object, especially a molecule, which has or produces a non-superimposeable mirror image of itself.<br /> <br /> =='''Dopamine'''==<br /> A neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system.<br /> <br /> =='''First pass metabolism'''==<br /> First pass metabolism is the process in which the liver starts to break down drugs before they reach systemic circulation. Different ROA's including insufflation are used to bypass this process to increase potency.<br /> <br /> =='''GABA'''==<br /> Gamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter.<br /> <br /> =='''GABA receptor'''==<br /> The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA).<br /> <br /> =='''Inverse agonist'''==<br /> an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.<br /> <br /> =='''Isomer'''==<br /> Each of two or more compounds with the same formula but a different arrangement of atoms in the molecule and different properties.<br /> <br /> =='''MAOI'''==<br /> Monoamine oxidase inhibitor any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate.<br /> <br /> =='''Monoamine Oxidase'''==<br /> An enzyme that catalyzes the metabolism of many drugs (e.g., DMT, dopamine and serotonin).<br /> <br /> =='''NMDA receptor''' A glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function.<br /> <br /> =='''Nootropics'''==<br /> These are a class of drugs that work by increasing levels of either/or neurotransmitters, enzymes, hormones, oxygen supply, and/or stimulating nerve growth. They are generaly neuroprotective, and extremely non-toxic.<br /> <br /> =='''Norepinephrine'''==<br /> Norepinephrine, or noradrenaline, is a catecholamine with multiple roles including as a hormone and a neurotransmitter.<br /> <br /> =='''Phenethylamine'''==<br /> Phenethylamine (PEA) is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. In the mammalian central nervous system, phenethylamine is believed to function as a neuromodulator or neurotransmitter.<br /> <br /> =='''Phenethylamine (substituted)'''==<br /> The substituted phenethylamines are a family of chemical compounds that contain the 2-phenylethylamine chemical structure and also have additional modifications at the phenyl ring, sidechain, and/or amino group (i.e. MDMA).<br /> <br /> =='''Re-uptake inhibitor'''==<br /> Also known as a transporter blocker, is a drug which inhibits the transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> =='''Releaser'''==<br /> A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> =='''Research Chemical'''==<br /> Designer drugs, a term used to describe drugs which are created (or marketed, if they had already existed) to get around existing drug laws, usually by modifying the molecular structures of existing drugs to varying degrees, or less commonly by finding drugs with entirely different chemical.<br /> <br /> =='''ROA'''==<br /> Common abbreviation for Route Of Administration, used to describe the various different methods of ingesting drugs, including oral, insufflation, sublingual/buccal, rectal, intramuscular (IM) and intravenous (IV) injection.<br /> <br /> =='''Inverse agonist '''==<br /> An inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist (i.e. Naloxone).<br /> <br /> =='''Serotonin (5-HT)'''==<br /> A monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being.<br /> <br /> =='''Tryptamine'''==<br /> Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived.</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Glossary&diff=3182 2014-07-21T06:03:42Z

<p>Denniskombucha: </p> <hr /> <div><br /> '''Agonist:''' A substance that initiates a physiological response when combined with a receptor.<br /> <br /> '''Amphetamine:''' A synthetic, addictive, mood-altering drug, used illegally as a stimulant and legally as a prescription drug to treat children with ADD and adults with narcolepsy. Substitutions can be made to the structure to give a variety of stimulants and psychedelics, which may be denoted as &quot;amphetamines&quot;.<br /> <br /> '''Antagonist:''' A substance that interferes with or inhibits the physiological action of another.<br /> <br /> '''Benzodiazepine:''' Any of a class of heterocyclic organic compounds effecting the GABA receptor complex used as tranquilizers, such as Librium and Valium.<br /> <br /> '''Cannabinoid:''' Chemicals produced naturally that bind to cannabinoid receptors. They are involved in a variety of mental and physical processes, including pain regulation, food intake, and reward.<br /> <br /> '''Cathinone:''' Cathinone, or Benzoylethanamine is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine and other amphetamines. Cathinone differs from amphetamine by possessing a ketone oxygen atom on the β position of the side chain.<br /> <br /> '''Chirality:''' The term chiral describes an object, especially a molecule, which has or produces a non-superimposeable mirror image of itself.<br /> <br /> '''Depressant:''' A drug that reduces functional or nervous activity.<br /> <br /> '''Dextromethorphan (DXM):''' An antitussive (cough suppressant) drug that also functions as a dissociative at higher doses.<br /> <br /> '''Dissociative:''' A class of psychedelic drugs characterized by intense feelings of depersonalization, derealization, and analgesia.<br /> <br /> '''Dopamine:''' A neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system.<br /> <br /> '''First pass metabolism:''' First pass metabolism is the process in which the liver starts to break down drugs before they reach systemic circulation. Different ROA's including insufflation are used to bypass this process to increase potency.<br /> <br /> '''GABA:''' Gamma aminobutyric acid: an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter.<br /> <br /> '''GABA receptor:''' The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA).<br /> <br /> '''GHB:''' Gamma Hydroxybutyrate. A clear liquid taken for its euphoric and relaxing effects.<br /> <br /> '''Inverse agonist:''' an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.<br /> <br /> '''Isomer:''' Each of two or more compounds with the same formula but a different arrangement of atoms in the molecule and different properties.<br /> <br /> '''Ketamine:''' A synthetic compound used as an anesthetic and analgesic drug and also (illicitly) as a dissassociative hallucinogen through NMDA antagonism.<br /> <br /> '''MAOI:''' Monoamine oxidase inhibitor: any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate.<br /> <br /> '''Monoamine Oxidase:''' An enzyme that catalyzes the metabolism of many drugs (e.g., DMT, dopamine and serotonin).<br /> <br /> '''NMDA receptor:''' A glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function.<br /> <br /> '''Nootropics:''' These are a class of drugs that work by increasing levels of either/or neurotransmitters, enzymes, hormones, oxygen supply, and/or stimulating nerve growth. They are generaly neuroprotective, and extremely non-toxic.<br /> <br /> '''Norepinephrine:''' Norepinephrine, or noradrenaline, is a catecholamine with multiple roles including as a hormone and a neurotransmitter.<br /> <br /> '''Opiate:''' Narcotic analgesic derived from a natural source (opium poppy).<br /> <br /> '''Opioid:''' Narcotic analgesic that is either semi or fully synthetic - also refers to entire family of both opiates and opioids.<br /> <br /> '''Phenethylamine:''' Phenethylamine (PEA) is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. In the mammalian central nervous system, phenethylamine is believed to function as a neuromodulator or neurotransmitter.<br /> <br /> '''Phenethylamine (substituted):''' The substituted phenethylamines are a family of chemical compounds that contain the 2-phenylethylamine chemical structure and also have additional modifications at the phenyl ring, sidechain, and/or amino group (i.e. MDMA).<br /> <br /> '''Re-uptake inhibitor:''' Also known as a transporter blocker, is a drug which inhibits the transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> '''Releaser:''' A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> '''Research Chemical:''' Designer drugs, a term used to describe drugs which are created (or marketed, if they had already existed) to get around existing drug laws, usually by modifying the molecular structures of existing drugs to varying degrees, or less commonly by finding drugs with entirely different chemical.<br /> <br /> '''ROA:''' Common abbreviation for Route Of Administration, used to describe the various different methods of ingesting drugs, including oral, insufflation, sublingual/buccal, rectal, intramuscular (IM) and intravenous (IV) injection.<br /> <br /> '''Inverse agonist:''' An inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist (i.e. Naloxone).<br /> <br /> '''Serotonin (5-HT):''' A monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being.<br /> <br /> '''Stimulant:''' A substance that raises levels of physiological or nervous activity in the body.<br /> <br /> '''Tryptamine:''' Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived.</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Glossary&diff=3181 2014-07-21T06:01:35Z

<p>Denniskombucha: </p> <hr /> <div>[[Glossary#Agonist]]<br /> <br /> '''Agonist:''' A substance that initiates a physiological response when combined with a receptor.<br /> <br /> '''Amphetamine:''' A synthetic, addictive, mood-altering drug, used illegally as a stimulant and legally as a prescription drug to treat children with ADD and adults with narcolepsy. Substitutions can be made to the structure to give a variety of stimulants and psychedelics, which may be denoted as &quot;amphetamines&quot;.<br /> <br /> '''Antagonist:''' A substance that interferes with or inhibits the physiological action of another.<br /> <br /> '''Benzodiazepine:''' Any of a class of heterocyclic organic compounds effecting the GABA receptor complex used as tranquilizers, such as Librium and Valium.<br /> <br /> '''Cannabinoid:''' Chemicals produced naturally that bind to cannabinoid receptors. They are involved in a variety of mental and physical processes, including pain regulation, food intake, and reward.<br /> <br /> '''Cathinone:''' Cathinone, or Benzoylethanamine is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine and other amphetamines. Cathinone differs from amphetamine by possessing a ketone oxygen atom on the β position of the side chain.<br /> <br /> '''Chirality:''' The term chiral describes an object, especially a molecule, which has or produces a non-superimposeable mirror image of itself.<br /> <br /> '''Depressant:''' A drug that reduces functional or nervous activity.<br /> <br /> '''Dextromethorphan (DXM):''' An antitussive (cough suppressant) drug that also functions as a dissociative at higher doses.<br /> <br /> '''Dissociative:''' A class of psychedelic drugs characterized by intense feelings of depersonalization, derealization, and analgesia.<br /> <br /> '''Dopamine:''' A neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system.<br /> <br /> '''First pass metabolism:''' First pass metabolism is the process in which the liver starts to break down drugs before they reach systemic circulation. Different ROA's including insufflation are used to bypass this process to increase potency.<br /> <br /> '''GABA:''' Gamma aminobutyric acid: an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter.<br /> <br /> '''GABA receptor:''' The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA).<br /> <br /> '''GHB:''' Gamma Hydroxybutyrate. A clear liquid taken for its euphoric and relaxing effects.<br /> <br /> '''Inverse agonist:''' an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.<br /> <br /> '''Isomer:''' Each of two or more compounds with the same formula but a different arrangement of atoms in the molecule and different properties.<br /> <br /> '''Ketamine:''' A synthetic compound used as an anesthetic and analgesic drug and also (illicitly) as a dissassociative hallucinogen through NMDA antagonism.<br /> <br /> '''MAOI:''' Monoamine oxidase inhibitor: any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate.<br /> <br /> '''Monoamine Oxidase:''' An enzyme that catalyzes the metabolism of many drugs (e.g., DMT, dopamine and serotonin).<br /> <br /> '''NMDA receptor:''' A glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function.<br /> <br /> '''Nootropics:''' These are a class of drugs that work by increasing levels of either/or neurotransmitters, enzymes, hormones, oxygen supply, and/or stimulating nerve growth. They are generaly neuroprotective, and extremely non-toxic.<br /> <br /> '''Norepinephrine:''' Norepinephrine, or noradrenaline, is a catecholamine with multiple roles including as a hormone and a neurotransmitter.<br /> <br /> '''Opiate:''' Narcotic analgesic derived from a natural source (opium poppy).<br /> <br /> '''Opioid:''' Narcotic analgesic that is either semi or fully synthetic - also refers to entire family of both opiates and opioids.<br /> <br /> '''Phenethylamine:''' Phenethylamine (PEA) is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. In the mammalian central nervous system, phenethylamine is believed to function as a neuromodulator or neurotransmitter.<br /> <br /> '''Phenethylamine (substituted):''' The substituted phenethylamines are a family of chemical compounds that contain the 2-phenylethylamine chemical structure and also have additional modifications at the phenyl ring, sidechain, and/or amino group (i.e. MDMA).<br /> <br /> '''Re-uptake inhibitor:''' Also known as a transporter blocker, is a drug which inhibits the transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> '''Releaser:''' A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter.<br /> <br /> '''Research Chemical:''' Designer drugs, a term used to describe drugs which are created (or marketed, if they had already existed) to get around existing drug laws, usually by modifying the molecular structures of existing drugs to varying degrees, or less commonly by finding drugs with entirely different chemical.<br /> <br /> '''ROA:''' Common abbreviation for Route Of Administration, used to describe the various different methods of ingesting drugs, including oral, insufflation, sublingual/buccal, rectal, intramuscular (IM) and intravenous (IV) injection.<br /> <br /> '''Inverse agonist:''' An inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist (i.e. Naloxone).<br /> <br /> '''Serotonin (5-HT):''' A monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being.<br /> <br /> '''Stimulant:''' A substance that raises levels of physiological or nervous activity in the body.<br /> <br /> '''Tryptamine:''' Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived.</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=How_To_Deal_With_A_Bad_Trip&diff=3173 2014-07-20T22:57:01Z

<p>Denniskombucha: /* Relaxing Music */</p> <hr /> <div>= What is a Bad Trip =<br /> <br /> A bad trip is defined as a trip, or stage of trip, which is disturbing and negative for the user. The most common manifestation of a bad trip is through negative thought loops; a user has a negative thought which they cannot let go of, and continues in a positive feedback loop becoming more negative. These can be triggered by ongoing life issues, a poor setting, or something as simple as worrying about having a bad trip.<br /> <br /> = How To Prevent a Bad Trip =<br /> <br /> The primary causes of a bad trip are entering the trip with a bad mindset. It's often repeated, but set and setting are the most important factors which will dictate the quality of a trip.<br /> <br /> Tripping while in a bad mood, or in an unstable mental state is likely to lead to negative thoughts and thereby a bad trip. Similarly, tripping in an uncomfortable environment, such as with people you don't know well, is liable to lead to negative thoughts.<br /> <br /> If it's your first time taking a new drug, it's always recommended to do so in the [[How_To_Tripsit_In_Real_Life|presence of a sober sitter]] - preferably one with experience in the given drug. Human contact can help reconnect a user to reality, and allay any paranoias.<br /> <br /> Some chemicals are particularly given to causing bad trips; for example, [[deliriants]] such as [[DPH]] are notorious for causing bad trips due to the scary nature of their hallucinations, and inability for the user to distinguish the effects of the drug from reality. It is recommended to avoid such drugs.<br /> <br /> = Dealing with a bad trip =<br /> <br /> Most bad trips are very similar to anxiety or panic attacks, and can be reversed by focusing on something positive or distracting yourself with some sort of entertainment.<br /> <br /> However, attempting to fight a bad experience is often liable to worsen things. It's helpful to focus on specific aspects that are discomforting and attempt to resolve them one at a time. You can start with easily solved issues of physical discomfort. Are you thirsty? Do you need to eat something? Having beverages and easy to eat foods like fruit can be very helpful. It's also useful to change your setting to change your mental state. If you have sombre music playing, you can put on something more light hearted or energetic. If things are feeling overwhelming, it can help to lie down and try to reduce the amount of input you have to deal with.<br /> <br /> Keep in mind that your experience will end, and that it's all a matter of time. Many bad trip situations are very similar to panic attacks, and as such the same techniques can be applied; mindfulness meditation and controlled breathing can help you calm yourself down.<br /> <br /> Breathe slowly and deeply. Inhale for four seconds, hold the breath for four seconds and then take another four seconds to exhale. This can help relax you and clear your mind when you're having a panic attack.<br /> <br /> Don't be discouraged that you have somehow 'ruined' your high. The more challenging experiences tend to be some of the most insightful ones. It you try to analyse if it's going bad or well it's easy to get into a reinforcing loop if you are feeling poorly. Focus on what you feel and what you are thinking, so that later on you can go over those feelings and thoughts to gain insight as to your thought processes.<br /> <br /> = Getting help =<br /> <br /> Sometimes, just talking to someone can help change the course of a bad trip. For this purpose, TripSit provides a 24 hour tripsitting service you can find [http://chat.tripsit.me/ here]. Come and say hi or type ~tripsit and we will be happy to talk with you!<br /> <br /> = Links =<br /> <br /> [https://www.erowid.org/library/books_online/essential_psychedelic_guide/essential_psychedelic_guide.shtml D. M. Turner - The Essential Psychedelic Guide]<br /> <br /> [https://en.wikipedia.org/wiki/Bad_trip Bad Trip - Wikipedia]<br /> <br /> = Relaxing Music =<br /> <br /> * [https://www.youtube.com/watch?v=bV-hSgL1R74 Halcyon On And On]<br /> <br /> * [http://www.youtube.com/watch?v=t989-ukRYTY Relaxing piano music]<br /> <br /> * [http://grooveshark.com/#!/playlist/Relax/84980264 Relaxing playlist]<br /> <br /> * [http://stereodose.com/ Music for some of the more classic drugs.]<br /> <br /> <br /> [[Category:Guides]]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Talk:How_To_Deal_With_A_Bad_Trip&diff=3171 2014-07-20T22:51:57Z

<p>Denniskombucha: Created page with &quot;On this page, should it be mentioned that tripping when the mood strikes might be more likely to induce a bad trip? IE &quot;I feel like tripping tonight, so what can I take?&quot; This...&quot;</p> <hr /> <div>On this page, should it be mentioned that tripping when the mood strikes might be more likely to induce a bad trip? IE &quot;I feel like tripping tonight, so what can I take?&quot;<br /> This should possibly be explored. For myself at least this seems to greatly increase the probability that a &quot;bad&quot; trip will occur.</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=User_talk:Denniskombucha&diff=3169 2014-07-20T22:47:17Z

<p>Denniskombucha: </p> <hr /> <div>'''Welcome to ''TripSit wiki''!'''<br /> We hope you will contribute much and well.<br /> You will probably want to read the [[Help:Contents|help pages]].<br /> Again, welcome and have fun! [[User:Reality|Reality]] ([[User talk:Reality|talk]]) 19:10, 22 September 2013 (CEST)<br /> <br /> Currently working on experimenting with methoxetamine, going to try and anecdotally discover if there is a body-weight dependent dosage, and may be interested in seeing if people are interested in working on this with me. The page also needs to be changed from being a word-for-word copy of the wikipedia page, and should probably be exponded upon a bit.<br /> <br /> May generally work on touching up grammar and readability of the wiki, shoot me a message if there's anything you feel is unreadable or could be made more coherent and I will look into working on it.</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Methoxetamine&diff=3167 2014-07-20T22:45:07Z

<p>Denniskombucha: /* General Information */</p> <hr /> <div>= General Information =<br /> Methoxetamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.<br /> <br /> = Dosage =<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | Threshold || 5-20mg<br /> |-<br /> | Low || 10-30mg<br /> |-<br /> | Common || 40-60mg<br /> |-<br /> | Strong || 50-100mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Insufflated<br /> |-<br /> | Threshold || 5-15mg<br /> |-<br /> | Low || 15-30mg<br /> |-<br /> | Common || 30-50mg<br /> |-<br /> | Strong || 50-75mg<br /> |-<br /> | Hole || 75-100mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Sublingual<br /> |-<br /> | Threshold || 5-10mg<br /> |-<br /> | Low || 10-20mg<br /> |-<br /> | Common || 40-60mg<br /> |-<br /> | Strong || 60-75mg<br /> |-<br /> | Hole || 75-100mg+<br /> |}<br /> <br /> = Duration =<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | Onset || 30-60 minutes<br /> |-<br /> | Total || 3-6 hours<br /> |-<br /> | After-effects || 2-48 hours (dose-dependent)<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Insufflated<br /> |-<br /> | Onset || 5-40 minutes<br /> |-<br /> | Total || 3-6 hours<br /> |-<br /> | After-effects || 2-48 hours (dose-dependent)<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Sublingual<br /> |-<br /> | Onset || 15-45 minutes<br /> |-<br /> | Total || 3-6 hours<br /> |-<br /> | After-effects || 2-48 hours (dose-dependent)<br /> |}<br /> <br /> = Effects =<br /> == Positive ==<br /> * Euphoria, mood lift<br /> * Sense of calm and serenity<br /> * Vivid recall of past memories and dreams<br /> * Closed- and open-eye visuals (common)<br /> * Out-of-body experience (less intense then ketamine)<br /> <br /> == Neutral ==<br /> * Distortion or loss of sensory perceptions (common)<br /> * Dissociation of mind from body<br /> * Sweating<br /> * Analgesia, numbness<br /> * Significant change in perception of time<br /> * Increase in heart rate<br /> * Confusion, disorientation<br /> <br /> == Negative ==<br /> * Risk of psychological dependency<br /> * Nasal discomfort upon insufflation<br /> * Blacking out and forgetting one has taken a drug<br /> * Discomfort, pain or numbness at injection site (with IM)<br /> * Severe confusion, disorganised thinking<br /> * Vertigo, spinning sensation (risk of injury)<br /> * Nausea, vomiting<br /> * Susceptibility to accidents (from uncoordination and change in perception of body and time)<br /> * Severe dissociation, depersonalisation<br /> * Loss of consciousness<br /> * Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)<br /> <br /> = Harm Reduction =<br /> * Avoid driving at all costs.<br /> * Avoid walking or moving around in general if you are on a medium to hole dose. <br /> * Taking this on a non-empty substance could lead to nausea.<br /> <br /> == Interactions ==<br /> [[Drug Combinations]]<br /> <br /> = Links = <br /> <br /> [https://en.wikipedia.org/wiki/Methoxetamine Wikipedia]<br /> <br /> [http://www.erowid.org/chemicals/methoxetamine/methoxetamine.shtml Erowid]<br /> <br /> [http://www.drugs-forum.com/forum/showwiki.php?title=Methoxetamine Drugs-Forum]<br /> <br /> [http://reddit.com/r/Drugs/comments/o9wam/rdrugs_ama_series_mxe_methoxetamine/?sort=top /r/Drugs FAQ]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Dissociative]]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Methoxetamine&diff=3166 2014-07-20T22:44:45Z

<p>Denniskombucha: /* General Information */</p> <hr /> <div>= General Information =<br /> Methoxetamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high dose DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.<br /> <br /> = Dosage =<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | Threshold || 5-20mg<br /> |-<br /> | Low || 10-30mg<br /> |-<br /> | Common || 40-60mg<br /> |-<br /> | Strong || 50-100mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Insufflated<br /> |-<br /> | Threshold || 5-15mg<br /> |-<br /> | Low || 15-30mg<br /> |-<br /> | Common || 30-50mg<br /> |-<br /> | Strong || 50-75mg<br /> |-<br /> | Hole || 75-100mg+<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Sublingual<br /> |-<br /> | Threshold || 5-10mg<br /> |-<br /> | Low || 10-20mg<br /> |-<br /> | Common || 40-60mg<br /> |-<br /> | Strong || 60-75mg<br /> |-<br /> | Hole || 75-100mg+<br /> |}<br /> <br /> = Duration =<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | Onset || 30-60 minutes<br /> |-<br /> | Total || 3-6 hours<br /> |-<br /> | After-effects || 2-48 hours (dose-dependent)<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Insufflated<br /> |-<br /> | Onset || 5-40 minutes<br /> |-<br /> | Total || 3-6 hours<br /> |-<br /> | After-effects || 2-48 hours (dose-dependent)<br /> |}<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Sublingual<br /> |-<br /> | Onset || 15-45 minutes<br /> |-<br /> | Total || 3-6 hours<br /> |-<br /> | After-effects || 2-48 hours (dose-dependent)<br /> |}<br /> <br /> = Effects =<br /> == Positive ==<br /> * Euphoria, mood lift<br /> * Sense of calm and serenity<br /> * Vivid recall of past memories and dreams<br /> * Closed- and open-eye visuals (common)<br /> * Out-of-body experience (less intense then ketamine)<br /> <br /> == Neutral ==<br /> * Distortion or loss of sensory perceptions (common)<br /> * Dissociation of mind from body<br /> * Sweating<br /> * Analgesia, numbness<br /> * Significant change in perception of time<br /> * Increase in heart rate<br /> * Confusion, disorientation<br /> <br /> == Negative ==<br /> * Risk of psychological dependency<br /> * Nasal discomfort upon insufflation<br /> * Blacking out and forgetting one has taken a drug<br /> * Discomfort, pain or numbness at injection site (with IM)<br /> * Severe confusion, disorganised thinking<br /> * Vertigo, spinning sensation (risk of injury)<br /> * Nausea, vomiting<br /> * Susceptibility to accidents (from uncoordination and change in perception of body and time)<br /> * Severe dissociation, depersonalisation<br /> * Loss of consciousness<br /> * Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)<br /> <br /> = Harm Reduction =<br /> * Avoid driving at all costs.<br /> * Avoid walking or moving around in general if you are on a medium to hole dose. <br /> * Taking this on a non-empty substance could lead to nausea.<br /> <br /> == Interactions ==<br /> [[Drug Combinations]]<br /> <br /> = Links = <br /> <br /> [https://en.wikipedia.org/wiki/Methoxetamine Wikipedia]<br /> <br /> [http://www.erowid.org/chemicals/methoxetamine/methoxetamine.shtml Erowid]<br /> <br /> [http://www.drugs-forum.com/forum/showwiki.php?title=Methoxetamine Drugs-Forum]<br /> <br /> [http://reddit.com/r/Drugs/comments/o9wam/rdrugs_ama_series_mxe_methoxetamine/?sort=top /r/Drugs FAQ]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Dissociative]]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=DOM&diff=3162 2014-07-19T13:07:14Z

<p>Denniskombucha: /* Important Substance Information */</p> <hr /> <div>== General Description ==<br /> DOM (2,5-Dimethoxy-4-methylamphetamine) is a psychdelic substituted amphetamine with effects similar to LSD. It has a slow come up, and an extremely long duration.<br /> <br /> == History ==<br /> DOM first saw human use in 1967, when tablets sold under the street name 'STP' started to become popular in the Haight-Ashbury District of San Francisco. These tabs contained an excessively high dose in the range of 15 to 20mg. This, combined with the long onset of the drug, led to numerous non-fatal overdoses.<br /> <br /> ==Dosage==<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | Threshold || 0.5-1mg<br /> |-<br /> | Light || 1-2mg<br /> |-<br /> | Common || 2-6mg+<br /> |-<br /> | Strong || 6-10mg<br /> |-<br /> | Heavy || 8-12mg<br /> |-<br /> | LD50 || 18mg/KG<br /> |}<br /> <br /> ==Duration==<br /> <br /> Note: This is a very dose dependent substance, with higher doses yielding longer, more intense results.<br /> <br /> {| class=&quot;wikitable&quot;<br /> |+ Oral<br /> |-<br /> | First effects || 1-2 hours<br /> |-<br /> | Coming up || 1-2 hours<br /> |-<br /> | Peak || 2-3 hours<br /> |-<br /> | Plateau || 4-6 hours<br /> |-<br /> | Coming down || 4-12 hours<br /> |-<br /> | After-effects || 4-16 hours<br /> |}<br /> <br /> == Important Substance Information ==<br /> DOM has been known to have a long comeup (up to 3 hours in some cases), as well as being one of the longer-acting psychedelic phenethylamines. For this reason, redosing is not recommended.<br /> <br /> == Images == <br /> <br /> &lt;gallery&gt;<br /> File:dom_blotter.jpg| ''5mg of DOM on blotter paper, US quarter for size comparison''<br /> File:dom_strip.jpg| ''5 blotters of DOM''<br /> File:Dom_powder.jpg| ''DOM in powder form''<br /> &lt;/gallery&gt;<br /> <br /> == Legal status ==<br /> <br /> === Europe === <br /> DOM is Class A in the UK, making it illegal to buy, sell, or possess without a license.<br /> <br /> === America === <br /> DOM is Schedule I in the United States. This means it is illegal to manufacture, buy, possess, or distribute (sell, trade or give) without a DEA license.<br /> <br /> <br /> [[Category:Drugs]]<br /> [[Category:Psychedelic]]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Ketamine&diff=1914 2013-12-19T14:35:57Z

<p>Denniskombucha: /* Harm Reduction */</p> <hr /> <div>== General Information ==<br /> <br /> [[File:Ketamine.png|Ketamine molecule]]<br /> <br /> '''Ketamine''' is a ''dissociative anesthetic'' that belongs to the arylcyclohexylamine class, and commonly used in human medical and veterinary care. It has a very wide safety margin, with an anesthetic dose being as much as ten times a recreational dose in an inexperienced user.<br /> <br /> === Introduction ===<br /> <br /> Ketamine is generally sold to the recreational user in one of two forms: in the evaporated salts, which are sold as a powder, or crystals (often referred to as shards), as well as in multi-dose vials for use in veterinary and human medicine. These vials may have concentrations ranging from 5mg/mL all the way up to 100mg/mL, and vary by manufacturer. One manufacturer, Parke-Davis, reports cases of accidental overdoses of ketamine as much as ten times higher than that required for surgery (which is to say 40-100x a recreational dose) &quot;with no obvious, lasting effects.&quot; It is, therefore, reasonable to consider it a drug of relatively safe usage.<br /> <br /> Because ketamine is a dissociative and an anesthetic, users are prone to becoming injured by interaction with their environment and have died from things such as drowning (DM Turner). Overdose, however, is unlikely.<br /> <br /> Ketamine is usually either injected intramuscularly (although intravenous administration does happen) or insufflated. Additional routes of administration are &quot;plugging&quot; (rectal) and orally. Oral availability of ketamine is poor.<br /> <br /> In some countries, such as Thailand and Mexico, ketamine is available over-the-counter without a prescription; legality for human use is questionable, however.<br /> <br /> === History ===<br /> <br /> Ketamine was originally produced by Parke-Davis laboratories in the early 1960s, and its recreational use was first reported in 1965; by the early 1970s, the US FDA was concerned about its use as a recreational drug. In the early 1990s, the US &quot;Drug Czar&quot; labeled ketamine as an &quot;emerging drug&quot; because of its involvement in the electronic music scene, and by 1999, it had been scheduled in the United States (Schedule III), although this designation is only applicable when the drug is intended for use in humans.<br /> <br /> == Dosage == <br /> <br /> These numbers are quoted directly from Erowid (which uses subjective dosage reports). Individual dosages will vary based on route of administration, tolerance and weight of the user, purity of the drug, as well as other conditions. It is always wise to start with a small dose and work up to a recreational dose. Remember, you cannot take less of the drug you have taken, but you can always take more.<br /> <br /> === A note on the &quot;k-hole&quot; ===<br /> <br /> There is no &quot;guaranteed&quot; dose to &quot;hole&quot; with ketamine. The &quot;k-hole&quot; as it is called is a state of full dissociative anesthesia in which the user is able to retain a semblance of consciousness. The effect associated with this is ego death; that is, the dissolution of the ego, the loss of the perspective of &quot;I&quot; in perception. It is a tricky dose to attain. Reaching too far with dosage will result in full anesthesia without memory of the experience and is worthless for recreational or psychonautical purposes. Too low a dosage will result in a mild sedation and body load, but no ego death, and redosing when anesthetized is tricky.<br /> <br /> It is posited that using a needle and a precisely measured dose is more likely to get a user to a full state of ego death, the k-hole, due to the lack of titration of dosage, rapid come-up, and exactly-metered dosage. Finding a dosage that &quot;works for you&quot; is important, and there will need to be a period of experimentation before such a dose is found. Assuming the user does not approach this dose very often, tolerance should not build, and it can be consistently used to reach that level of effect/ego death.<br /> <br /> It may be helpful for the user to measure out doses in syringes before using if a re-dose is desired; pulling a new shot can be difficult while under the effects of ketamine, and takes time while the drug is wearing off. Administering a shot while anesthetized can be perilous at best; for this reason, re-dosing is not recommended. If one must re-dose, use of an &quot;auto-ject&quot; like device (a spring loaded syringe) is convenient.<br /> <br /> Because the &quot;k-hole&quot; involves full dissociative anesthesia, it is crucial that the user be in a safe place, physically, such as lying flat in bed. It may be useful to have a sitter present because arousal from the k-hole may be disorienting.<br /> <br /> Understand, however, that there is no guaranteed mechanism for &quot;reaching the hole,&quot; and it takes practice. Become familiar with the drug before taking large doses such as those required to reach the &quot;hole.&quot; Find a dose that works for you.<br /> <br /> === Oral ===<br /> <br /> 1-4mg/lb of body mass. Doses higher than 3mg/lb may exceed the recreational window and leave the user anesthetized rather than &quot;tripping.&quot; Doses of 2-3mg/lb may incur greater (short-term) memory loss and have little additional value as a psychedelic.<br /> <br /> === Insufflated === <br /> <br /> Threshold effects may begin at about .25mg/lb body mass, and recreational doses can range up to 2mg/lb, with common doses being 1mg/lb of body mass. As above, higher doses may not yield greater desirable effect. Ketamine is reported to be fairly gentle on the nasal tissues compared to brominated phenethylamines and organofluorides.<br /> <br /> <br /> === Intramuscular injection === <br /> <br /> Typically 1mg/lb body mass for IM injection is quite sufficient for a full dissociative experience. Doses of .5-.75mg/lb are more &quot;threshold&quot; and cogent experiences. Doses exceeding 1mg/lb body mass usually result in full anesthesia with little recall of the experience and may take longer to recover. There may be short-term memory loss with higher doses.<br /> <br /> Onset: &lt; 2 minutes.<br /> Duration: major effects &lt; 60 minutes; tertiary effects 90 minutes; return to baseline 120 minutes.<br /> <br /> === Intravenous injection ===<br /> <br /> Intravenous injection is possible with ketamine. The doses are the same as for intramuscular injection. However, with intravenous injection, the user can become fully anesthetized before she is able to remove the needle from her body. For this reason alone intravenous injection of ketamine is discouraged. Additionally, intramuscular injection provides a near-identical experience with the only major difference being a shorter (&lt; 1 minute vs &lt; 2 minutes) come-up.<br /> <br /> == Preparation of injectable ketamine solution from &quot;street&quot; ketamine ==<br /> <br /> It is assumed that ketamine provided is simply the evaporated shards of veterinary-grade ketamine (e.g., Ketalar, Ketaset, etc). These instructions do not cover &quot;extraction&quot; of ketamine from non-ketamine-containing mixtures. Additionally, the assumed route of administration here is intramuscular, not intravenous; intravenous solutions can have a higher concentration of ketamine per ml.<br /> <br /> ==== A note on purity of &quot;street&quot; ketamine ====<br /> <br /> Anecdotal evidence suggests that even the &quot;cleanest&quot; ketamine available on the street cannot be sterile, or even assured to be 100% ketamine (common household dust and debris being an example of non-deliberate contamination; too small to see in a powder, but big enough to cause a problem for injection). If the procedure below is followed without the step of using the syringe filter of appropriate depth, particulate will appear in the final solution. These particles may be made sterile by boiling or the addition of benzyl alcohol. However, they can clog needles, and more importantly, they can lead to abscesses (sterile and non-sterile) in the muscles chosen for injection. This can become a medical emergency, and may need to be [http://www.thegooddrugsguide.com/gallery/before-and-after-drug-abuse/steroid-abuse/abusing-fake-steroids.htm surgically removed] ('''warning: graphic content'''). Early treatment is possible with antibiotics. An abscess will feel like a &quot;lump&quot; under the skin at the injection site, will usually be visibly raised, and warm to the touch. Seek treatment early if you have these symptoms.<br /> <br /> === Materiel ===<br /> <br /> * Sterile saline solution<br /> * Ketamine powder or &quot;shards&quot;<br /> * Benzyl alcohol<br /> * Sterile 10ml multi-dose vials<br /> * Septums (&quot;tops&quot;) per each multi-dose vial<br /> * Sterile glass stirring rods<br /> * Sterile beaker or graduated cylinder of greater than 50ml capacity<br /> * Sterile syringe filters (22μm)<br /> * Sterile 20cc syringes<br /> * Temperature-controlled hot plate with magnetic stirring device or glass stirring rods, above<br /> <br /> === Preparation ===<br /> <br /> Ketamine is quite soluble in water up to about 200mg/ml when warm and closer to 100mg/ml at room temperature.<br /> <br /> # To begin, measure out one gram (1g) of ketamine per 10ml of saline solution used. Heat water in the beaker or cylinder to 80°C.<br /> ::''note:'' boiling is preferable but will throw off the total volume of water and thus the ratio of ketamine per cc.<br /> # Per 10ml, measure out .1ml of benzyl alcohol (1%), and dispense to each multi-dose vial.<br /> ::''note:'' benzyl alcohol and benzyl benzoate are soluble in water, but require stirring and heating. Either should stay in solution after the water is heated and subsequently cools.<br /> <br /> # Add ketamine powder to the heated water.<br /> # Stir using a glass stirring rod or magnetic stirring device.<br /> # When powder is visibly dissolved in the sterile solution, meter out 10ml of the solution using a 20cc syringe per 10ml vial.<br /> # Using the 22μm syringe filter, add 10ml of the ketamine solution per multi-dose vial, pushing through (not pulling through) the syringe filter.<br /> # Apply septum to each multi-dose vial and allow solution to cool to at most 30°C.<br /> <br /> ===Notes on parenteral usage===<br /> <br /> Always use a test injection of e.g., 1/10th cc (in this case, 10mg) before actually using a therapeutic or recreational dose.<br /> <br /> Benzyl benzoate may be used instead of benzyl alcohol at 1-2% per volume as a preservative/antimicrobial agent.<br /> <br /> Ketamine is highly soluble in water at room- and body temperature. That said, for intramuscular injection, it is very important to ensure the solution will not &quot;crash&quot; (come out of solution) post-injection because of the solution cooling. Under no circumstances should you prepare a solution of greater than 100mg/ml or inject a solution that is above body temperature.<br /> :''' ''note'' ''': left in a multi-dose vial or in syringes, ketamine can come out of solution if the ambient temperature dips low enough. there is at least one anecdote of a winter breeze through a domicile cooling both syringes and a vial sufficiently that crystals began to condense from the solution. obviously one should not attempt to inject the contents of a syringe if crystalline content is evident.<br /> <br /> With benzyl alcohol or benzyl benzoate, in sterile sealed vials, having been processed through a syringe filter, and kept above freezing, this solution should remain quite stable and sterile indefinitely.<br /> <br /> == Effects == <br /> <br /> === Positive === <br /> <br /> * Ego death is a state often sought in the use of psychedelics, and ketamine is often considered to be a very quick route to ego death, in a repeatable, safe way.<br /> * Some users report euphoria.<br /> * Pain relief.<br /> * There has been some indication that ketamine, in low doses (20-30mg), can be an effective anti-depressant.<br /> <br /> === Neutral === <br /> <br /> <br /> <br /> === Negative === <br /> <br /> * Long-term, chronic usage may lead to psychosis.<br /> * Bladder and [http://www.erowid.org/chemicals/ketamine/ketamine_article2.shtml lower urinary tract discomfort], up to and including tissue necrosis requiring replacement of bladder, ureters, and urethra, has been reported. If these effects are noticed, discontinue use immediately. There is no known treatment for this except cessation of use. Symptoms may subside with discontinuation.<br /> * Ketamine is well-known in the psychedelics community to be habit-forming. It may not be technically 'physically addictive', but certainly psychological dependence is an issue that is widely reported.<br /> * Any substance used intramuscularly or intravenously can be associated with abscesses among other hazards.<br /> <br /> === After effects ===<br /> <br /> * Ketamine takes much longer to return to a complete baseline than is immediately apparent to the user. While major effects subside in usually less than an hour, some research has shown it can take a day or longer for more subtle psychological effects to subside. For this reason, it is important to be careful with redosing and daily usage.<br /> <br /> == Harm Reduction ==<br /> <br /> * Avoid driving.<br /> <br /> * Avoid walking or moving in general if possible.<br /> <br /> * A full stomach may lead to nausea; consider fasting 3-4+ hours before usage.<br /> <br /> &lt;!--<br /> <br /> * Recommended time (pauses) between using the substance<br /> <br /> * Addiction potential?<br /> <br /> * Risk of death?<br /> <br /> * Mental illness?<br /> <br /> * Heart issues?<br /> <br /> * Bladder problems?<br /> --&gt;<br /> <br /> == Chemistry and Pharmacology == <br /> <br /> === Production ===<br /> <br /> == Images ==<br /> [[File:ketamine_molecule.gif|3D model of ketamine molecule]]<br /> <br /> == Legal Status ==<br /> <br /> * United States: [http://www.justice.gov/dea/druginfo/ds.shtml Schedule III]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Ketamine&diff=1913 2013-12-19T14:35:26Z

<p>Denniskombucha: /* Positive */</p> <hr /> <div>== General Information ==<br /> <br /> [[File:Ketamine.png|Ketamine molecule]]<br /> <br /> '''Ketamine''' is a ''dissociative anesthetic'' that belongs to the arylcyclohexylamine class, and commonly used in human medical and veterinary care. It has a very wide safety margin, with an anesthetic dose being as much as ten times a recreational dose in an inexperienced user.<br /> <br /> === Introduction ===<br /> <br /> Ketamine is generally sold to the recreational user in one of two forms: in the evaporated salts, which are sold as a powder, or crystals (often referred to as shards), as well as in multi-dose vials for use in veterinary and human medicine. These vials may have concentrations ranging from 5mg/mL all the way up to 100mg/mL, and vary by manufacturer. One manufacturer, Parke-Davis, reports cases of accidental overdoses of ketamine as much as ten times higher than that required for surgery (which is to say 40-100x a recreational dose) &quot;with no obvious, lasting effects.&quot; It is, therefore, reasonable to consider it a drug of relatively safe usage.<br /> <br /> Because ketamine is a dissociative and an anesthetic, users are prone to becoming injured by interaction with their environment and have died from things such as drowning (DM Turner). Overdose, however, is unlikely.<br /> <br /> Ketamine is usually either injected intramuscularly (although intravenous administration does happen) or insufflated. Additional routes of administration are &quot;plugging&quot; (rectal) and orally. Oral availability of ketamine is poor.<br /> <br /> In some countries, such as Thailand and Mexico, ketamine is available over-the-counter without a prescription; legality for human use is questionable, however.<br /> <br /> === History ===<br /> <br /> Ketamine was originally produced by Parke-Davis laboratories in the early 1960s, and its recreational use was first reported in 1965; by the early 1970s, the US FDA was concerned about its use as a recreational drug. In the early 1990s, the US &quot;Drug Czar&quot; labeled ketamine as an &quot;emerging drug&quot; because of its involvement in the electronic music scene, and by 1999, it had been scheduled in the United States (Schedule III), although this designation is only applicable when the drug is intended for use in humans.<br /> <br /> == Dosage == <br /> <br /> These numbers are quoted directly from Erowid (which uses subjective dosage reports). Individual dosages will vary based on route of administration, tolerance and weight of the user, purity of the drug, as well as other conditions. It is always wise to start with a small dose and work up to a recreational dose. Remember, you cannot take less of the drug you have taken, but you can always take more.<br /> <br /> === A note on the &quot;k-hole&quot; ===<br /> <br /> There is no &quot;guaranteed&quot; dose to &quot;hole&quot; with ketamine. The &quot;k-hole&quot; as it is called is a state of full dissociative anesthesia in which the user is able to retain a semblance of consciousness. The effect associated with this is ego death; that is, the dissolution of the ego, the loss of the perspective of &quot;I&quot; in perception. It is a tricky dose to attain. Reaching too far with dosage will result in full anesthesia without memory of the experience and is worthless for recreational or psychonautical purposes. Too low a dosage will result in a mild sedation and body load, but no ego death, and redosing when anesthetized is tricky.<br /> <br /> It is posited that using a needle and a precisely measured dose is more likely to get a user to a full state of ego death, the k-hole, due to the lack of titration of dosage, rapid come-up, and exactly-metered dosage. Finding a dosage that &quot;works for you&quot; is important, and there will need to be a period of experimentation before such a dose is found. Assuming the user does not approach this dose very often, tolerance should not build, and it can be consistently used to reach that level of effect/ego death.<br /> <br /> It may be helpful for the user to measure out doses in syringes before using if a re-dose is desired; pulling a new shot can be difficult while under the effects of ketamine, and takes time while the drug is wearing off. Administering a shot while anesthetized can be perilous at best; for this reason, re-dosing is not recommended. If one must re-dose, use of an &quot;auto-ject&quot; like device (a spring loaded syringe) is convenient.<br /> <br /> Because the &quot;k-hole&quot; involves full dissociative anesthesia, it is crucial that the user be in a safe place, physically, such as lying flat in bed. It may be useful to have a sitter present because arousal from the k-hole may be disorienting.<br /> <br /> Understand, however, that there is no guaranteed mechanism for &quot;reaching the hole,&quot; and it takes practice. Become familiar with the drug before taking large doses such as those required to reach the &quot;hole.&quot; Find a dose that works for you.<br /> <br /> === Oral ===<br /> <br /> 1-4mg/lb of body mass. Doses higher than 3mg/lb may exceed the recreational window and leave the user anesthetized rather than &quot;tripping.&quot; Doses of 2-3mg/lb may incur greater (short-term) memory loss and have little additional value as a psychedelic.<br /> <br /> === Insufflated === <br /> <br /> Threshold effects may begin at about .25mg/lb body mass, and recreational doses can range up to 2mg/lb, with common doses being 1mg/lb of body mass. As above, higher doses may not yield greater desirable effect. Ketamine is reported to be fairly gentle on the nasal tissues compared to brominated phenethylamines and organofluorides.<br /> <br /> <br /> === Intramuscular injection === <br /> <br /> Typically 1mg/lb body mass for IM injection is quite sufficient for a full dissociative experience. Doses of .5-.75mg/lb are more &quot;threshold&quot; and cogent experiences. Doses exceeding 1mg/lb body mass usually result in full anesthesia with little recall of the experience and may take longer to recover. There may be short-term memory loss with higher doses.<br /> <br /> Onset: &lt; 2 minutes.<br /> Duration: major effects &lt; 60 minutes; tertiary effects 90 minutes; return to baseline 120 minutes.<br /> <br /> === Intravenous injection ===<br /> <br /> Intravenous injection is possible with ketamine. The doses are the same as for intramuscular injection. However, with intravenous injection, the user can become fully anesthetized before she is able to remove the needle from her body. For this reason alone intravenous injection of ketamine is discouraged. Additionally, intramuscular injection provides a near-identical experience with the only major difference being a shorter (&lt; 1 minute vs &lt; 2 minutes) come-up.<br /> <br /> == Preparation of injectable ketamine solution from &quot;street&quot; ketamine ==<br /> <br /> It is assumed that ketamine provided is simply the evaporated shards of veterinary-grade ketamine (e.g., Ketalar, Ketaset, etc). These instructions do not cover &quot;extraction&quot; of ketamine from non-ketamine-containing mixtures. Additionally, the assumed route of administration here is intramuscular, not intravenous; intravenous solutions can have a higher concentration of ketamine per ml.<br /> <br /> ==== A note on purity of &quot;street&quot; ketamine ====<br /> <br /> Anecdotal evidence suggests that even the &quot;cleanest&quot; ketamine available on the street cannot be sterile, or even assured to be 100% ketamine (common household dust and debris being an example of non-deliberate contamination; too small to see in a powder, but big enough to cause a problem for injection). If the procedure below is followed without the step of using the syringe filter of appropriate depth, particulate will appear in the final solution. These particles may be made sterile by boiling or the addition of benzyl alcohol. However, they can clog needles, and more importantly, they can lead to abscesses (sterile and non-sterile) in the muscles chosen for injection. This can become a medical emergency, and may need to be [http://www.thegooddrugsguide.com/gallery/before-and-after-drug-abuse/steroid-abuse/abusing-fake-steroids.htm surgically removed] ('''warning: graphic content'''). Early treatment is possible with antibiotics. An abscess will feel like a &quot;lump&quot; under the skin at the injection site, will usually be visibly raised, and warm to the touch. Seek treatment early if you have these symptoms.<br /> <br /> === Materiel ===<br /> <br /> * Sterile saline solution<br /> * Ketamine powder or &quot;shards&quot;<br /> * Benzyl alcohol<br /> * Sterile 10ml multi-dose vials<br /> * Septums (&quot;tops&quot;) per each multi-dose vial<br /> * Sterile glass stirring rods<br /> * Sterile beaker or graduated cylinder of greater than 50ml capacity<br /> * Sterile syringe filters (22μm)<br /> * Sterile 20cc syringes<br /> * Temperature-controlled hot plate with magnetic stirring device or glass stirring rods, above<br /> <br /> === Preparation ===<br /> <br /> Ketamine is quite soluble in water up to about 200mg/ml when warm and closer to 100mg/ml at room temperature.<br /> <br /> # To begin, measure out one gram (1g) of ketamine per 10ml of saline solution used. Heat water in the beaker or cylinder to 80°C.<br /> ::''note:'' boiling is preferable but will throw off the total volume of water and thus the ratio of ketamine per cc.<br /> # Per 10ml, measure out .1ml of benzyl alcohol (1%), and dispense to each multi-dose vial.<br /> ::''note:'' benzyl alcohol and benzyl benzoate are soluble in water, but require stirring and heating. Either should stay in solution after the water is heated and subsequently cools.<br /> <br /> # Add ketamine powder to the heated water.<br /> # Stir using a glass stirring rod or magnetic stirring device.<br /> # When powder is visibly dissolved in the sterile solution, meter out 10ml of the solution using a 20cc syringe per 10ml vial.<br /> # Using the 22μm syringe filter, add 10ml of the ketamine solution per multi-dose vial, pushing through (not pulling through) the syringe filter.<br /> # Apply septum to each multi-dose vial and allow solution to cool to at most 30°C.<br /> <br /> ===Notes on parenteral usage===<br /> <br /> Always use a test injection of e.g., 1/10th cc (in this case, 10mg) before actually using a therapeutic or recreational dose.<br /> <br /> Benzyl benzoate may be used instead of benzyl alcohol at 1-2% per volume as a preservative/antimicrobial agent.<br /> <br /> Ketamine is highly soluble in water at room- and body temperature. That said, for intramuscular injection, it is very important to ensure the solution will not &quot;crash&quot; (come out of solution) post-injection because of the solution cooling. Under no circumstances should you prepare a solution of greater than 100mg/ml or inject a solution that is above body temperature.<br /> :''' ''note'' ''': left in a multi-dose vial or in syringes, ketamine can come out of solution if the ambient temperature dips low enough. there is at least one anecdote of a winter breeze through a domicile cooling both syringes and a vial sufficiently that crystals began to condense from the solution. obviously one should not attempt to inject the contents of a syringe if crystalline content is evident.<br /> <br /> With benzyl alcohol or benzyl benzoate, in sterile sealed vials, having been processed through a syringe filter, and kept above freezing, this solution should remain quite stable and sterile indefinitely.<br /> <br /> == Effects == <br /> <br /> === Positive === <br /> <br /> * Ego death is a state often sought in the use of psychedelics, and ketamine is often considered to be a very quick route to ego death, in a repeatable, safe way.<br /> * Some users report euphoria.<br /> * Pain relief.<br /> * There has been some indication that ketamine, in low doses (20-30mg), can be an effective anti-depressant.<br /> <br /> === Neutral === <br /> <br /> <br /> <br /> === Negative === <br /> <br /> * Long-term, chronic usage may lead to psychosis.<br /> * Bladder and [http://www.erowid.org/chemicals/ketamine/ketamine_article2.shtml lower urinary tract discomfort], up to and including tissue necrosis requiring replacement of bladder, ureters, and urethra, has been reported. If these effects are noticed, discontinue use immediately. There is no known treatment for this except cessation of use. Symptoms may subside with discontinuation.<br /> * Ketamine is well-known in the psychedelics community to be habit-forming. It may not be technically 'physically addictive', but certainly psychological dependence is an issue that is widely reported.<br /> * Any substance used intramuscularly or intravenously can be associated with abscesses among other hazards.<br /> <br /> === After effects ===<br /> <br /> * Ketamine takes much longer to return to a complete baseline than is immediately apparent to the user. While major effects subside in usually less than an hour, some research has shown it can take a day or longer for more subtle psychological effects to subside. For this reason, it is important to be careful with redosing and daily usage.<br /> <br /> == Harm Reduction ==<br /> <br /> * Avoid driving.<br /> <br /> * Avoid walking or moving in general if possible.<br /> <br /> * Non-empty stomach may lead to nausea; consider fasting 3-4+ hours before usage.<br /> <br /> &lt;!--<br /> <br /> * Recommended time (pauses) between using the substance<br /> <br /> * Addiction potential?<br /> <br /> * Risk of death?<br /> <br /> * Mental illness?<br /> <br /> * Heart issues?<br /> <br /> --&gt;<br /> <br /> == Chemistry and Pharmacology == <br /> <br /> === Production ===<br /> <br /> == Images ==<br /> [[File:ketamine_molecule.gif|3D model of ketamine molecule]]<br /> <br /> == Legal Status ==<br /> <br /> * United States: [http://www.justice.gov/dea/druginfo/ds.shtml Schedule III]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Ketamine&diff=1912 2013-12-19T14:33:43Z

<p>Denniskombucha: /* Dosage */</p> <hr /> <div>== General Information ==<br /> <br /> [[File:Ketamine.png|Ketamine molecule]]<br /> <br /> '''Ketamine''' is a ''dissociative anesthetic'' that belongs to the arylcyclohexylamine class, and commonly used in human medical and veterinary care. It has a very wide safety margin, with an anesthetic dose being as much as ten times a recreational dose in an inexperienced user.<br /> <br /> === Introduction ===<br /> <br /> Ketamine is generally sold to the recreational user in one of two forms: in the evaporated salts, which are sold as a powder, or crystals (often referred to as shards), as well as in multi-dose vials for use in veterinary and human medicine. These vials may have concentrations ranging from 5mg/mL all the way up to 100mg/mL, and vary by manufacturer. One manufacturer, Parke-Davis, reports cases of accidental overdoses of ketamine as much as ten times higher than that required for surgery (which is to say 40-100x a recreational dose) &quot;with no obvious, lasting effects.&quot; It is, therefore, reasonable to consider it a drug of relatively safe usage.<br /> <br /> Because ketamine is a dissociative and an anesthetic, users are prone to becoming injured by interaction with their environment and have died from things such as drowning (DM Turner). Overdose, however, is unlikely.<br /> <br /> Ketamine is usually either injected intramuscularly (although intravenous administration does happen) or insufflated. Additional routes of administration are &quot;plugging&quot; (rectal) and orally. Oral availability of ketamine is poor.<br /> <br /> In some countries, such as Thailand and Mexico, ketamine is available over-the-counter without a prescription; legality for human use is questionable, however.<br /> <br /> === History ===<br /> <br /> Ketamine was originally produced by Parke-Davis laboratories in the early 1960s, and its recreational use was first reported in 1965; by the early 1970s, the US FDA was concerned about its use as a recreational drug. In the early 1990s, the US &quot;Drug Czar&quot; labeled ketamine as an &quot;emerging drug&quot; because of its involvement in the electronic music scene, and by 1999, it had been scheduled in the United States (Schedule III), although this designation is only applicable when the drug is intended for use in humans.<br /> <br /> == Dosage == <br /> <br /> These numbers are quoted directly from Erowid (which uses subjective dosage reports). Individual dosages will vary based on route of administration, tolerance and weight of the user, purity of the drug, as well as other conditions. It is always wise to start with a small dose and work up to a recreational dose. Remember, you cannot take less of the drug you have taken, but you can always take more.<br /> <br /> === A note on the &quot;k-hole&quot; ===<br /> <br /> There is no &quot;guaranteed&quot; dose to &quot;hole&quot; with ketamine. The &quot;k-hole&quot; as it is called is a state of full dissociative anesthesia in which the user is able to retain a semblance of consciousness. The effect associated with this is ego death; that is, the dissolution of the ego, the loss of the perspective of &quot;I&quot; in perception. It is a tricky dose to attain. Reaching too far with dosage will result in full anesthesia without memory of the experience and is worthless for recreational or psychonautical purposes. Too low a dosage will result in a mild sedation and body load, but no ego death, and redosing when anesthetized is tricky.<br /> <br /> It is posited that using a needle and a precisely measured dose is more likely to get a user to a full state of ego death, the k-hole, due to the lack of titration of dosage, rapid come-up, and exactly-metered dosage. Finding a dosage that &quot;works for you&quot; is important, and there will need to be a period of experimentation before such a dose is found. Assuming the user does not approach this dose very often, tolerance should not build, and it can be consistently used to reach that level of effect/ego death.<br /> <br /> It may be helpful for the user to measure out doses in syringes before using if a re-dose is desired; pulling a new shot can be difficult while under the effects of ketamine, and takes time while the drug is wearing off. Administering a shot while anesthetized can be perilous at best; for this reason, re-dosing is not recommended. If one must re-dose, use of an &quot;auto-ject&quot; like device (a spring loaded syringe) is convenient.<br /> <br /> Because the &quot;k-hole&quot; involves full dissociative anesthesia, it is crucial that the user be in a safe place, physically, such as lying flat in bed. It may be useful to have a sitter present because arousal from the k-hole may be disorienting.<br /> <br /> Understand, however, that there is no guaranteed mechanism for &quot;reaching the hole,&quot; and it takes practice. Become familiar with the drug before taking large doses such as those required to reach the &quot;hole.&quot; Find a dose that works for you.<br /> <br /> === Oral ===<br /> <br /> 1-4mg/lb of body mass. Doses higher than 3mg/lb may exceed the recreational window and leave the user anesthetized rather than &quot;tripping.&quot; Doses of 2-3mg/lb may incur greater (short-term) memory loss and have little additional value as a psychedelic.<br /> <br /> === Insufflated === <br /> <br /> Threshold effects may begin at about .25mg/lb body mass, and recreational doses can range up to 2mg/lb, with common doses being 1mg/lb of body mass. As above, higher doses may not yield greater desirable effect. Ketamine is reported to be fairly gentle on the nasal tissues compared to brominated phenethylamines and organofluorides.<br /> <br /> <br /> === Intramuscular injection === <br /> <br /> Typically 1mg/lb body mass for IM injection is quite sufficient for a full dissociative experience. Doses of .5-.75mg/lb are more &quot;threshold&quot; and cogent experiences. Doses exceeding 1mg/lb body mass usually result in full anesthesia with little recall of the experience and may take longer to recover. There may be short-term memory loss with higher doses.<br /> <br /> Onset: &lt; 2 minutes.<br /> Duration: major effects &lt; 60 minutes; tertiary effects 90 minutes; return to baseline 120 minutes.<br /> <br /> === Intravenous injection ===<br /> <br /> Intravenous injection is possible with ketamine. The doses are the same as for intramuscular injection. However, with intravenous injection, the user can become fully anesthetized before she is able to remove the needle from her body. For this reason alone intravenous injection of ketamine is discouraged. Additionally, intramuscular injection provides a near-identical experience with the only major difference being a shorter (&lt; 1 minute vs &lt; 2 minutes) come-up.<br /> <br /> == Preparation of injectable ketamine solution from &quot;street&quot; ketamine ==<br /> <br /> It is assumed that ketamine provided is simply the evaporated shards of veterinary-grade ketamine (e.g., Ketalar, Ketaset, etc). These instructions do not cover &quot;extraction&quot; of ketamine from non-ketamine-containing mixtures. Additionally, the assumed route of administration here is intramuscular, not intravenous; intravenous solutions can have a higher concentration of ketamine per ml.<br /> <br /> ==== A note on purity of &quot;street&quot; ketamine ====<br /> <br /> Anecdotal evidence suggests that even the &quot;cleanest&quot; ketamine available on the street cannot be sterile, or even assured to be 100% ketamine (common household dust and debris being an example of non-deliberate contamination; too small to see in a powder, but big enough to cause a problem for injection). If the procedure below is followed without the step of using the syringe filter of appropriate depth, particulate will appear in the final solution. These particles may be made sterile by boiling or the addition of benzyl alcohol. However, they can clog needles, and more importantly, they can lead to abscesses (sterile and non-sterile) in the muscles chosen for injection. This can become a medical emergency, and may need to be [http://www.thegooddrugsguide.com/gallery/before-and-after-drug-abuse/steroid-abuse/abusing-fake-steroids.htm surgically removed] ('''warning: graphic content'''). Early treatment is possible with antibiotics. An abscess will feel like a &quot;lump&quot; under the skin at the injection site, will usually be visibly raised, and warm to the touch. Seek treatment early if you have these symptoms.<br /> <br /> === Materiel ===<br /> <br /> * Sterile saline solution<br /> * Ketamine powder or &quot;shards&quot;<br /> * Benzyl alcohol<br /> * Sterile 10ml multi-dose vials<br /> * Septums (&quot;tops&quot;) per each multi-dose vial<br /> * Sterile glass stirring rods<br /> * Sterile beaker or graduated cylinder of greater than 50ml capacity<br /> * Sterile syringe filters (22μm)<br /> * Sterile 20cc syringes<br /> * Temperature-controlled hot plate with magnetic stirring device or glass stirring rods, above<br /> <br /> === Preparation ===<br /> <br /> Ketamine is quite soluble in water up to about 200mg/ml when warm and closer to 100mg/ml at room temperature.<br /> <br /> # To begin, measure out one gram (1g) of ketamine per 10ml of saline solution used. Heat water in the beaker or cylinder to 80°C.<br /> ::''note:'' boiling is preferable but will throw off the total volume of water and thus the ratio of ketamine per cc.<br /> # Per 10ml, measure out .1ml of benzyl alcohol (1%), and dispense to each multi-dose vial.<br /> ::''note:'' benzyl alcohol and benzyl benzoate are soluble in water, but require stirring and heating. Either should stay in solution after the water is heated and subsequently cools.<br /> <br /> # Add ketamine powder to the heated water.<br /> # Stir using a glass stirring rod or magnetic stirring device.<br /> # When powder is visibly dissolved in the sterile solution, meter out 10ml of the solution using a 20cc syringe per 10ml vial.<br /> # Using the 22μm syringe filter, add 10ml of the ketamine solution per multi-dose vial, pushing through (not pulling through) the syringe filter.<br /> # Apply septum to each multi-dose vial and allow solution to cool to at most 30°C.<br /> <br /> ===Notes on parenteral usage===<br /> <br /> Always use a test injection of e.g., 1/10th cc (in this case, 10mg) before actually using a therapeutic or recreational dose.<br /> <br /> Benzyl benzoate may be used instead of benzyl alcohol at 1-2% per volume as a preservative/antimicrobial agent.<br /> <br /> Ketamine is highly soluble in water at room- and body temperature. That said, for intramuscular injection, it is very important to ensure the solution will not &quot;crash&quot; (come out of solution) post-injection because of the solution cooling. Under no circumstances should you prepare a solution of greater than 100mg/ml or inject a solution that is above body temperature.<br /> :''' ''note'' ''': left in a multi-dose vial or in syringes, ketamine can come out of solution if the ambient temperature dips low enough. there is at least one anecdote of a winter breeze through a domicile cooling both syringes and a vial sufficiently that crystals began to condense from the solution. obviously one should not attempt to inject the contents of a syringe if crystalline content is evident.<br /> <br /> With benzyl alcohol or benzyl benzoate, in sterile sealed vials, having been processed through a syringe filter, and kept above freezing, this solution should remain quite stable and sterile indefinitely.<br /> <br /> == Effects == <br /> <br /> === Positive === <br /> <br /> * Ego death is a state often sought in the use of psychedelics, and ketamine is a very quick route to ego death, in a repeatable, safe way.<br /> * Some users report euphoria.<br /> * Pain relief.<br /> * There has been some indication that ketamine, in low doses (20-30mg), can be an effective anti-depressant.<br /> <br /> === Neutral === <br /> <br /> <br /> <br /> === Negative === <br /> <br /> * Long-term, chronic usage may lead to psychosis.<br /> * Bladder and [http://www.erowid.org/chemicals/ketamine/ketamine_article2.shtml lower urinary tract discomfort], up to and including tissue necrosis requiring replacement of bladder, ureters, and urethra, has been reported. If these effects are noticed, discontinue use immediately. There is no known treatment for this except cessation of use. Symptoms may subside with discontinuation.<br /> * Ketamine is well-known in the psychedelics community to be habit-forming. It may not be technically 'physically addictive', but certainly psychological dependence is an issue that is widely reported.<br /> * Any substance used intramuscularly or intravenously can be associated with abscesses among other hazards.<br /> <br /> === After effects ===<br /> <br /> * Ketamine takes much longer to return to a complete baseline than is immediately apparent to the user. While major effects subside in usually less than an hour, some research has shown it can take a day or longer for more subtle psychological effects to subside. For this reason, it is important to be careful with redosing and daily usage.<br /> <br /> == Harm Reduction ==<br /> <br /> * Avoid driving.<br /> <br /> * Avoid walking or moving in general if possible.<br /> <br /> * Non-empty stomach may lead to nausea; consider fasting 3-4+ hours before usage.<br /> <br /> &lt;!--<br /> <br /> * Recommended time (pauses) between using the substance<br /> <br /> * Addiction potential?<br /> <br /> * Risk of death?<br /> <br /> * Mental illness?<br /> <br /> * Heart issues?<br /> <br /> --&gt;<br /> <br /> == Chemistry and Pharmacology == <br /> <br /> === Production ===<br /> <br /> == Images ==<br /> [[File:ketamine_molecule.gif|3D model of ketamine molecule]]<br /> <br /> == Legal Status ==<br /> <br /> * United States: [http://www.justice.gov/dea/druginfo/ds.shtml Schedule III]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Ketamine&diff=1911 2013-12-19T14:29:20Z

<p>Denniskombucha: /* General Information */</p> <hr /> <div>== General Information ==<br /> <br /> [[File:Ketamine.png|Ketamine molecule]]<br /> <br /> '''Ketamine''' is a ''dissociative anesthetic'' that belongs to the arylcyclohexylamine class, and commonly used in human medical and veterinary care. It has a very wide safety margin, with an anesthetic dose being as much as ten times a recreational dose in an inexperienced user.<br /> <br /> === Introduction ===<br /> <br /> Ketamine is generally sold to the recreational user in one of two forms: in the evaporated salts, which are sold as a powder, or crystals (often referred to as shards), as well as in multi-dose vials for use in veterinary and human medicine. These vials may have concentrations ranging from 5mg/mL all the way up to 100mg/mL, and vary by manufacturer. One manufacturer, Parke-Davis, reports cases of accidental overdoses of ketamine as much as ten times higher than that required for surgery (which is to say 40-100x a recreational dose) &quot;with no obvious, lasting effects.&quot; It is, therefore, reasonable to consider it a drug of relatively safe usage.<br /> <br /> Because ketamine is a dissociative and an anesthetic, users are prone to becoming injured by interaction with their environment and have died from things such as drowning (DM Turner). Overdose, however, is unlikely.<br /> <br /> Ketamine is usually either injected intramuscularly (although intravenous administration does happen) or insufflated. Additional routes of administration are &quot;plugging&quot; (rectal) and orally. Oral availability of ketamine is poor.<br /> <br /> In some countries, such as Thailand and Mexico, ketamine is available over-the-counter without a prescription; legality for human use is questionable, however.<br /> <br /> === History ===<br /> <br /> Ketamine was originally produced by Parke-Davis laboratories in the early 1960s, and its recreational use was first reported in 1965; by the early 1970s, the US FDA was concerned about its use as a recreational drug. In the early 1990s, the US &quot;Drug Czar&quot; labeled ketamine as an &quot;emerging drug&quot; because of its involvement in the electronic music scene, and by 1999, it had been scheduled in the United States (Schedule III), although this designation is only applicable when the drug is intended for use in humans.<br /> <br /> == Dosage == <br /> <br /> These numbers are quoted directly from Erowid (which uses subjective dosage reports…). Individual dosages will vary based on route of administration, tolerance of the user, purity of the drug, weight of the user, and other conditions. It is always wise to start with a small dose and work up to a recreational dose. Remember, you cannot take less of the drug you have taken, but you can always take more.<br /> <br /> === A note on the &quot;k-hole&quot; ===<br /> <br /> There is no &quot;guaranteed&quot; dose to &quot;hole&quot; with ketamine. The &quot;k-hole&quot; as it is called is a state of full dissociative anesthesia in which the user is able to retain a semblance of consciousness. The effect associated with this is ego death; that is, the dissolution of the ego, the loss of the perspective of &quot;I&quot; in perception. It is a tricky dose to attain. Reaching too far with dosage will result in full anesthesia without memory of the experience and is worthless for recreational or psychonaut purposes. Too low a dosage will result in a mild sedation and body load, but no ego death, and redosing when anesthetized is tricky.<br /> <br /> It is posited that using a needle and a precisely measured dose is more likely to get a user to a full state of ego death, the k-hole, due to the lack of titration of dosage, rapid come-up, and exactly-metered dosage. Finding a dosage that &quot;works for you&quot; is important, and there will need to be a period of experimentation before such a dose is found. Assuming the user does not approach this dose very often, tolerance should not build, and it can be consistently used to reach that level of effect/ego death.<br /> <br /> It may be helpful for the user to measure out doses in syringes before using if a re-dose is desired; pulling a new shot can be difficult while under the effects of ketamine, and takes time while the drug is wearing off. Administering a shot while anesthetized can be perilous at best; for this reason, re-dosing is not recommended. If one must re-dose, use of an &quot;auto-ject&quot; like device (a spring loaded syringe) is convenient.<br /> <br /> Because the &quot;k-hole&quot; involves full dissociative anesthesia, it is crucial that the user be in a safe place, physically, such as lying flat in bed. It may be useful to have a sitter present because arousal from the k-hole may be disorienting.<br /> <br /> Understand, however, that there is no guaranteed mechanism for &quot;reaching the hole,&quot; and it takes practice. Become familiar with the drug before taking heroic doses. Find a dose that works for you.<br /> <br /> === Oral ===<br /> <br /> 1-4mg/lb of body mass. Doses higher than 3mg/lb may exceed the recreational window and leave the user anesthetized rather than &quot;tripping.&quot; Doses of 2-3mg/lb may incur greater (short-term) memory loss and have little additional value as a psychedelic.<br /> <br /> === Insufflated === <br /> <br /> Threshold effects may begin about 1/4mg/lb body mass, and recreational doses can range up to 2mg/lb, with common doses being 1mg per 1lb of body mass. As above, higher doses may not yield greater desirable effect. Ketamine is reported to be fairly gentle on the nasal tissues compared to brominated phenethylamines and organofluorides.<br /> <br /> <br /> === Intramuscular injection === <br /> <br /> Typically 1mg/lb body mass for IM injection is quite sufficient for a full dissociative experience. Doses of .5-.75mg/lb are more &quot;threshold&quot; and cogent experiences. Doses exceeding 1mg/lb body mass usually result in full anesthesia with little recall of the experience and may take longer to recover. There may be short-term memory loss with higher doses.<br /> <br /> Onset: &lt; 2 minutes.<br /> Duration: major effects &lt; 60 minutes; tertiary effects 90 minutes; return to baseline 120 minutes.<br /> <br /> === Intravenous injection ===<br /> <br /> Intravenous injection is possible with ketamine. The doses are the same as for intramuscular injection. However, with intravenous injection, the user can become fully anesthetized before she is able to remove the needle from her body. For this reason alone intravenous injection of ketamine is discouraged. Additionally, intramuscular injection provides a near-identical experience with the only major difference being a shorter (&lt; 1 minute vs &lt; 2 minutes) come-up.<br /> <br /> == Preparation of injectable ketamine solution from &quot;street&quot; ketamine ==<br /> <br /> It is assumed that ketamine provided is simply the evaporated shards of veterinary-grade ketamine (e.g., Ketalar, Ketaset, etc). These instructions do not cover &quot;extraction&quot; of ketamine from non-ketamine-containing mixtures. Additionally, the assumed route of administration here is intramuscular, not intravenous; intravenous solutions can have a higher concentration of ketamine per ml.<br /> <br /> ==== A note on purity of &quot;street&quot; ketamine ====<br /> <br /> Anecdotal evidence suggests that even the &quot;cleanest&quot; ketamine available on the street cannot be sterile, or even assured to be 100% ketamine (common household dust and debris being an example of non-deliberate contamination; too small to see in a powder, but big enough to cause a problem for injection). If the procedure below is followed without the step of using the syringe filter of appropriate depth, particulate will appear in the final solution. These particles may be made sterile by boiling or the addition of benzyl alcohol. However, they can clog needles, and more importantly, they can lead to abscesses (sterile and non-sterile) in the muscles chosen for injection. This can become a medical emergency, and may need to be [http://www.thegooddrugsguide.com/gallery/before-and-after-drug-abuse/steroid-abuse/abusing-fake-steroids.htm surgically removed] ('''warning: graphic content'''). Early treatment is possible with antibiotics. An abscess will feel like a &quot;lump&quot; under the skin at the injection site, will usually be visibly raised, and warm to the touch. Seek treatment early if you have these symptoms.<br /> <br /> === Materiel ===<br /> <br /> * Sterile saline solution<br /> * Ketamine powder or &quot;shards&quot;<br /> * Benzyl alcohol<br /> * Sterile 10ml multi-dose vials<br /> * Septums (&quot;tops&quot;) per each multi-dose vial<br /> * Sterile glass stirring rods<br /> * Sterile beaker or graduated cylinder of greater than 50ml capacity<br /> * Sterile syringe filters (22μm)<br /> * Sterile 20cc syringes<br /> * Temperature-controlled hot plate with magnetic stirring device or glass stirring rods, above<br /> <br /> === Preparation ===<br /> <br /> Ketamine is quite soluble in water up to about 200mg/ml when warm and closer to 100mg/ml at room temperature.<br /> <br /> # To begin, measure out one gram (1g) of ketamine per 10ml of saline solution used. Heat water in the beaker or cylinder to 80°C.<br /> ::''note:'' boiling is preferable but will throw off the total volume of water and thus the ratio of ketamine per cc.<br /> # Per 10ml, measure out .1ml of benzyl alcohol (1%), and dispense to each multi-dose vial.<br /> ::''note:'' benzyl alcohol and benzyl benzoate are soluble in water, but require stirring and heating. Either should stay in solution after the water is heated and subsequently cools.<br /> <br /> # Add ketamine powder to the heated water.<br /> # Stir using a glass stirring rod or magnetic stirring device.<br /> # When powder is visibly dissolved in the sterile solution, meter out 10ml of the solution using a 20cc syringe per 10ml vial.<br /> # Using the 22μm syringe filter, add 10ml of the ketamine solution per multi-dose vial, pushing through (not pulling through) the syringe filter.<br /> # Apply septum to each multi-dose vial and allow solution to cool to at most 30°C.<br /> <br /> ===Notes on parenteral usage===<br /> <br /> Always use a test injection of e.g., 1/10th cc (in this case, 10mg) before actually using a therapeutic or recreational dose.<br /> <br /> Benzyl benzoate may be used instead of benzyl alcohol at 1-2% per volume as a preservative/antimicrobial agent.<br /> <br /> Ketamine is highly soluble in water at room- and body temperature. That said, for intramuscular injection, it is very important to ensure the solution will not &quot;crash&quot; (come out of solution) post-injection because of the solution cooling. Under no circumstances should you prepare a solution of greater than 100mg/ml or inject a solution that is above body temperature.<br /> :''' ''note'' ''': left in a multi-dose vial or in syringes, ketamine can come out of solution if the ambient temperature dips low enough. there is at least one anecdote of a winter breeze through a domicile cooling both syringes and a vial sufficiently that crystals began to condense from the solution. obviously one should not attempt to inject the contents of a syringe if crystalline content is evident.<br /> <br /> With benzyl alcohol or benzyl benzoate, in sterile sealed vials, having been processed through a syringe filter, and kept above freezing, this solution should remain quite stable and sterile indefinitely.<br /> <br /> == Effects == <br /> <br /> === Positive === <br /> <br /> * Ego death is a state often sought in the use of psychedelics, and ketamine is a very quick route to ego death, in a repeatable, safe way.<br /> * Some users report euphoria.<br /> * Pain relief.<br /> * There has been some indication that ketamine, in low doses (20-30mg), can be an effective anti-depressant.<br /> <br /> === Neutral === <br /> <br /> <br /> <br /> === Negative === <br /> <br /> * Long-term, chronic usage may lead to psychosis.<br /> * Bladder and [http://www.erowid.org/chemicals/ketamine/ketamine_article2.shtml lower urinary tract discomfort], up to and including tissue necrosis requiring replacement of bladder, ureters, and urethra, has been reported. If these effects are noticed, discontinue use immediately. There is no known treatment for this except cessation of use. Symptoms may subside with discontinuation.<br /> * Ketamine is well-known in the psychedelics community to be habit-forming. It may not be technically 'physically addictive', but certainly psychological dependence is an issue that is widely reported.<br /> * Any substance used intramuscularly or intravenously can be associated with abscesses among other hazards.<br /> <br /> === After effects ===<br /> <br /> * Ketamine takes much longer to return to a complete baseline than is immediately apparent to the user. While major effects subside in usually less than an hour, some research has shown it can take a day or longer for more subtle psychological effects to subside. For this reason, it is important to be careful with redosing and daily usage.<br /> <br /> == Harm Reduction ==<br /> <br /> * Avoid driving.<br /> <br /> * Avoid walking or moving in general if possible.<br /> <br /> * Non-empty stomach may lead to nausea; consider fasting 3-4+ hours before usage.<br /> <br /> &lt;!--<br /> <br /> * Recommended time (pauses) between using the substance<br /> <br /> * Addiction potential?<br /> <br /> * Risk of death?<br /> <br /> * Mental illness?<br /> <br /> * Heart issues?<br /> <br /> --&gt;<br /> <br /> == Chemistry and Pharmacology == <br /> <br /> === Production ===<br /> <br /> == Images ==<br /> [[File:ketamine_molecule.gif|3D model of ketamine molecule]]<br /> <br /> == Legal Status ==<br /> <br /> * United States: [http://www.justice.gov/dea/druginfo/ds.shtml Schedule III]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=Ketamine&diff=1910 2013-12-19T13:55:15Z

<p>Denniskombucha: /* Positive */</p> <hr /> <div>== General Information ==<br /> <br /> [[File:Ketamine.png|Ketamine molecule]]<br /> <br /> '''Ketamine''' is a ''dissociative anesthetic'' that belong to arylcyclohexylamines, and commonly used in human medical care, and veterinary. It has a very wide safety margin, with a anesthetic dose being as much as ten times a recreational dose in a naive user.<br /> <br /> === Introduction ===<br /> <br /> Ketamine is generally sold to the recreational user in one of two forms: in the evaporated salts, which are sold as a powder, or crystals called shards, as well as in the multi-dose vials for use in veterinary and human medicine. These latter vials may have concentrations of 5mg/mL all the way up to 100mg/mL, and vary by manufacturer. One manufacturer, Parke-Davis, reports cases of accidental overdoses of ketamine as much as ten times higher than that required for surgery (which is to say 40-100x a recreational dose) &quot;with no obvious, lasting effects.&quot; It is therefore reasonable to consider it a drug of relatively safe usage.<br /> <br /> Because ketamine is a dissociative and an anesthetic, users are prone to becoming injured by interaction with their environment and have died from e.g., drowning (DM Turner). Overdose, however, is unlikely.<br /> <br /> Ketamine is usually used either injected intramuscularly (although intravenous administration does happen) or insufflated. Additional routes of administration are &quot;plugging&quot; (rectal) and orally. Oral availability of ketamine is poor.<br /> <br /> In some countries, such as Thailand and Mexico, ketamine is available over-the-counter without a prescription; legality for human use is questionable, however.<br /> <br /> As a solid, ketamine is either a bright white powder, or crystals (&quot;shards&quot;) resembling rock salt.<br /> <br /> === History ===<br /> <br /> Ketamine was originally produced by Parke-Davis laboratories in the early 1960s, and its recreational use was first reported in 1965; by the early 1970s, the US FDA was concerned about its use as a recreational drug. In the early 1990s, the US &quot;Drug Czar&quot; labeled ketamine as an &quot;emerging drug&quot; because of its involvement in the electronic music scene, and by 1999, it had been scheduled in the United States (Schedule III), although this designation is only applicable when the drug is intended for use in humans.<br /> <br /> == Dosage == <br /> <br /> These numbers are quoted directly from Erowid (which uses subjective dosage reports…). Individual dosages will vary based on route of administration, tolerance of the user, purity of the drug, weight of the user, and other conditions. It is always wise to start with a small dose and work up to a recreational dose. Remember, you cannot take less of the drug you have taken, but you can always take more.<br /> <br /> === A note on the &quot;k-hole&quot; ===<br /> <br /> There is no &quot;guaranteed&quot; dose to &quot;hole&quot; with ketamine. The &quot;k-hole&quot; as it is called is a state of full dissociative anesthesia in which the user is able to retain a semblance of consciousness. The effect associated with this is ego death; that is, the dissolution of the ego, the loss of the perspective of &quot;I&quot; in perception. It is a tricky dose to attain. Reaching too far with dosage will result in full anesthesia without memory of the experience and is worthless for recreational or psychonaut purposes. Too low a dosage will result in a mild sedation and body load, but no ego death, and redosing when anesthetized is tricky.<br /> <br /> It is posited that using a needle and a precisely measured dose is more likely to get a user to a full state of ego death, the k-hole, due to the lack of titration of dosage, rapid come-up, and exactly-metered dosage. Finding a dosage that &quot;works for you&quot; is important, and there will need to be a period of experimentation before such a dose is found. Assuming the user does not approach this dose very often, tolerance should not build, and it can be consistently used to reach that level of effect/ego death.<br /> <br /> It may be helpful for the user to measure out doses in syringes before using if a re-dose is desired; pulling a new shot can be difficult while under the effects of ketamine, and takes time while the drug is wearing off. Administering a shot while anesthetized can be perilous at best; for this reason, re-dosing is not recommended. If one must re-dose, use of an &quot;auto-ject&quot; like device (a spring loaded syringe) is convenient.<br /> <br /> Because the &quot;k-hole&quot; involves full dissociative anesthesia, it is crucial that the user be in a safe place, physically, such as lying flat in bed. It may be useful to have a sitter present because arousal from the k-hole may be disorienting.<br /> <br /> Understand, however, that there is no guaranteed mechanism for &quot;reaching the hole,&quot; and it takes practice. Become familiar with the drug before taking heroic doses. Find a dose that works for you.<br /> <br /> === Oral ===<br /> <br /> 1-4mg/lb of body mass. Doses higher than 3mg/lb may exceed the recreational window and leave the user anesthetized rather than &quot;tripping.&quot; Doses of 2-3mg/lb may incur greater (short-term) memory loss and have little additional value as a psychedelic.<br /> <br /> === Insufflated === <br /> <br /> Threshold effects may begin about 1/4mg/lb body mass, and recreational doses can range up to 2mg/lb, with common doses being 1mg per 1lb of body mass. As above, higher doses may not yield greater desirable effect. Ketamine is reported to be fairly gentle on the nasal tissues compared to brominated phenethylamines and organofluorides.<br /> <br /> <br /> === Intramuscular injection === <br /> <br /> Typically 1mg/lb body mass for IM injection is quite sufficient for a full dissociative experience. Doses of .5-.75mg/lb are more &quot;threshold&quot; and cogent experiences. Doses exceeding 1mg/lb body mass usually result in full anesthesia with little recall of the experience and may take longer to recover. There may be short-term memory loss with higher doses.<br /> <br /> Onset: &lt; 2 minutes.<br /> Duration: major effects &lt; 60 minutes; tertiary effects 90 minutes; return to baseline 120 minutes.<br /> <br /> === Intravenous injection ===<br /> <br /> Intravenous injection is possible with ketamine. The doses are the same as for intramuscular injection. However, with intravenous injection, the user can become fully anesthetized before she is able to remove the needle from her body. For this reason alone intravenous injection of ketamine is discouraged. Additionally, intramuscular injection provides a near-identical experience with the only major difference being a shorter (&lt; 1 minute vs &lt; 2 minutes) come-up.<br /> <br /> == Preparation of injectable ketamine solution from &quot;street&quot; ketamine ==<br /> <br /> It is assumed that ketamine provided is simply the evaporated shards of veterinary-grade ketamine (e.g., Ketalar, Ketaset, etc). These instructions do not cover &quot;extraction&quot; of ketamine from non-ketamine-containing mixtures. Additionally, the assumed route of administration here is intramuscular, not intravenous; intravenous solutions can have a higher concentration of ketamine per ml.<br /> <br /> ==== A note on purity of &quot;street&quot; ketamine ====<br /> <br /> Anecdotal evidence suggests that even the &quot;cleanest&quot; ketamine available on the street cannot be sterile, or even assured to be 100% ketamine (common household dust and debris being an example of non-deliberate contamination; too small to see in a powder, but big enough to cause a problem for injection). If the procedure below is followed without the step of using the syringe filter of appropriate depth, particulate will appear in the final solution. These particles may be made sterile by boiling or the addition of benzyl alcohol. However, they can clog needles, and more importantly, they can lead to abscesses (sterile and non-sterile) in the muscles chosen for injection. This can become a medical emergency, and may need to be [http://www.thegooddrugsguide.com/gallery/before-and-after-drug-abuse/steroid-abuse/abusing-fake-steroids.htm surgically removed] ('''warning: graphic content'''). Early treatment is possible with antibiotics. An abscess will feel like a &quot;lump&quot; under the skin at the injection site, will usually be visibly raised, and warm to the touch. Seek treatment early if you have these symptoms.<br /> <br /> === Materiel ===<br /> <br /> * Sterile saline solution<br /> * Ketamine powder or &quot;shards&quot;<br /> * Benzyl alcohol<br /> * Sterile 10ml multi-dose vials<br /> * Septums (&quot;tops&quot;) per each multi-dose vial<br /> * Sterile glass stirring rods<br /> * Sterile beaker or graduated cylinder of greater than 50ml capacity<br /> * Sterile syringe filters (22μm)<br /> * Sterile 20cc syringes<br /> * Temperature-controlled hot plate with magnetic stirring device or glass stirring rods, above<br /> <br /> === Preparation ===<br /> <br /> Ketamine is quite soluble in water up to about 200mg/ml when warm and closer to 100mg/ml at room temperature.<br /> <br /> # To begin, measure out one gram (1g) of ketamine per 10ml of saline solution used. Heat water in the beaker or cylinder to 80°C.<br /> ::''note:'' boiling is preferable but will throw off the total volume of water and thus the ratio of ketamine per cc.<br /> # Per 10ml, measure out .1ml of benzyl alcohol (1%), and dispense to each multi-dose vial.<br /> ::''note:'' benzyl alcohol and benzyl benzoate are soluble in water, but require stirring and heating. Either should stay in solution after the water is heated and subsequently cools.<br /> <br /> # Add ketamine powder to the heated water.<br /> # Stir using a glass stirring rod or magnetic stirring device.<br /> # When powder is visibly dissolved in the sterile solution, meter out 10ml of the solution using a 20cc syringe per 10ml vial.<br /> # Using the 22μm syringe filter, add 10ml of the ketamine solution per multi-dose vial, pushing through (not pulling through) the syringe filter.<br /> # Apply septum to each multi-dose vial and allow solution to cool to at most 30°C.<br /> <br /> ===Notes on parenteral usage===<br /> <br /> Always use a test injection of e.g., 1/10th cc (in this case, 10mg) before actually using a therapeutic or recreational dose.<br /> <br /> Benzyl benzoate may be used instead of benzyl alcohol at 1-2% per volume as a preservative/antimicrobial agent.<br /> <br /> Ketamine is highly soluble in water at room- and body temperature. That said, for intramuscular injection, it is very important to ensure the solution will not &quot;crash&quot; (come out of solution) post-injection because of the solution cooling. Under no circumstances should you prepare a solution of greater than 100mg/ml or inject a solution that is above body temperature.<br /> :''' ''note'' ''': left in a multi-dose vial or in syringes, ketamine can come out of solution if the ambient temperature dips low enough. there is at least one anecdote of a winter breeze through a domicile cooling both syringes and a vial sufficiently that crystals began to condense from the solution. obviously one should not attempt to inject the contents of a syringe if crystalline content is evident.<br /> <br /> With benzyl alcohol or benzyl benzoate, in sterile sealed vials, having been processed through a syringe filter, and kept above freezing, this solution should remain quite stable and sterile indefinitely.<br /> <br /> == Effects == <br /> <br /> === Positive === <br /> <br /> * Ego death is a state often sought in the use of psychedelics, and ketamine is a very quick route to ego death, in a repeatable, safe way.<br /> * Some users report euphoria.<br /> * Pain relief.<br /> * There has been some indication that ketamine, in low doses (20-30mg), can be an effective anti-depressant.<br /> <br /> === Neutral === <br /> <br /> <br /> <br /> === Negative === <br /> <br /> * Long-term, chronic usage may lead to psychosis.<br /> * Bladder and [http://www.erowid.org/chemicals/ketamine/ketamine_article2.shtml lower urinary tract discomfort], up to and including tissue necrosis requiring replacement of bladder, ureters, and urethra, has been reported. If these effects are noticed, discontinue use immediately. There is no known treatment for this except cessation of use. Symptoms may subside with discontinuation.<br /> * Ketamine is well-known in the psychedelics community to be habit-forming. It may not be technically 'physically addictive', but certainly psychological dependence is an issue that is widely reported.<br /> * Any substance used intramuscularly or intravenously can be associated with abscesses among other hazards.<br /> <br /> === After effects ===<br /> <br /> * Ketamine takes much longer to return to a complete baseline than is immediately apparent to the user. While major effects subside in usually less than an hour, some research has shown it can take a day or longer for more subtle psychological effects to subside. For this reason, it is important to be careful with redosing and daily usage.<br /> <br /> == Harm Reduction ==<br /> <br /> * Avoid driving.<br /> <br /> * Avoid walking or moving in general if possible.<br /> <br /> * Non-empty stomach may lead to nausea; consider fasting 3-4+ hours before usage.<br /> <br /> &lt;!--<br /> <br /> * Recommended time (pauses) between using the substance<br /> <br /> * Addiction potential?<br /> <br /> * Risk of death?<br /> <br /> * Mental illness?<br /> <br /> * Heart issues?<br /> <br /> --&gt;<br /> <br /> == Chemistry and Pharmacology == <br /> <br /> === Production ===<br /> <br /> == Images ==<br /> [[File:ketamine_molecule.gif|3D model of ketamine molecule]]<br /> <br /> == Legal Status ==<br /> <br /> * United States: [http://www.justice.gov/dea/druginfo/ds.shtml Schedule III]</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=TripSitter_Orientation&diff=1908 2013-12-16T21:52:37Z

<p>Denniskombucha: </p> <hr /> <div>= Welcome to your first step into the TripSit network! =<br /> <br /> Based on your commendable performance, your willingness to help out, and your positive attitude towards the people here, you have been accepted as staff in the TripSit network. Here's some vital information about the network and staffing to help you perform well in your new position! Please review all of the following points and return here if you have any questions. When you have finished reading, please let an admin know. <br /> <br /> == History ==<br /> <br /> The TripSit network was founded by Techno_shaman (Teknos) in reddit.com/r/tripsit on June 1st, 2012. It progressed into an IRC channel on Sept 2, 2012 and continues to increase it's focus around harm reduction and providing a safe community for the world's Psychonaut community. It has since grown into a website, live web radio, and social network. So far, we have helped countless people in many different ways. We have been featured by MAPS and we've had several news articles written about us. We're currently expanding our social network and working on developing a real-life presence at festivals and concerts, and you're invited to be a part in the next step in growing our network.<br /> <br /> == Definitions ==<br /> <br /> *'''Voice''': The +v flag gives a user a spiffy icon and thus 'status' as someone to be trusted. Voiced users can also say !flags to get a list of staff in that room. <br /> <br /> *'''Operator''': The +o flag gives a user the ability to ban someone from a channel. These people will either be a mod or an admin on the network.<br /> <br /> *'''Staff''': Having a flag in one of our public rooms excluding #drugsvip.<br /> <br /> *'''Tripsitter''': User with +voice in #tripsit. Can not kick/ban, but can invite and view !flags.<br /> <br /> *'''Power User''': User that guides discussion in a positive manner. Cannot kick or ban. Can use ~quiet to silence problem users. <br /> <br /> *'''Moderator''': Having the ability to kick and ban users from channels.<br /> <br /> *'''Admin''': Responsible for the general administration of the network. <br /> <br /> *'''Report''': To ~report #channel User Reason sends a PM to all staff in that room. Avalible to anyone in channel.<br /> <br /> *'''Notify''': ~notify #channel NOTICE is a way to send a PM to all staff in that channel. Available to anyone in channel.<br /> <br /> *'''Tripbot''': A multi-use omnibot that is quickly approaching sentience. <br /> <br /> *'''Bot''': An RSS and utility bot. <br /> <br /> *'''Warning''': To ~warn USER REASON sets a note on that user. Available to PowerUsers and higher<br /> <br /> * '''~ (tilde)''': The prefix for tripbot commands<br /> <br /> * '''@ (at)''': Prefix for tagging users when reporting to tripbot. (Eg. if you and another user helped somebody in #tripsit, you would '~notify #tripsit user summary' and tag the user that helped with @user in the summary)<br /> <br /> * '''! (exclamation)''': The prefix for Bot commands<br /> <br /> * '''Sourcing''': Defined as &quot;discussion of where to specifically purchase or otherwise acquire substances of any kind; this includes links to legal substance vendors and paraphernalia. This rule does not necessarily apply to scales or other dosing related items, as they aid in harm reduction.<br /> <br /> == Tripbot ==<br /> <br /> === Introduction ===<br /> <br /> Tripbot is a multi-use omnibot that includes many features we rely on to do an efficient job of moderating the network. <br /> <br /> <br /> === Webinterface ===<br /> <br /> Located [http://nourishedcloud.com:1337 here], your username is myuser@tripsit, and you can set a password by issuing the '~setwebpass mypassword' command. Please PM tripbot to keep your password confidential. Contact reality if you have any issues.<br /> <br /> === Entry Alert ===<br /> <br /> ~gettripsitentries to receive them, ~notripsitentries to stop receiving them.<br /> <br /> This will alert you when a previously unrecognised host enters #tripsit who may potentially need help. <br /> <br /> === Other Commands ===<br /> <br /> See ~tripbotcommands. These commands are constantly updating. New commands will be shared via Tripbot notifications.<br /> <br /> == Feedback System ==<br /> <br /> === Report ===<br /> <br /> Syntax: ~report &lt;user&gt; &lt;room&gt; &lt;message&gt;<br /> <br /> *Available to all users. This will send a notice to everyone voiced in the channel you reported to. For example: &quot;~report #drugs Teknos debauchery&quot; will report Teknos to everyone with the +v flag in #drugs for the reason of debauchery. Commonly used for problem users in #drugs and other channels. When responding to a report by talking with the user, send a ~notify to #teamtripsit to acknowledge that staff has followed through on a report. Encourage regular users to employ use of this command, we rely on reports to know when things are not right.<br /> <br /> === Warning ===<br /> <br /> Syntax: ~warn &lt;user&gt; &lt;message&gt; <br /> <br /> *Available to Power Users and higher. Warnings are counted and permanently stored online for staff to view past events. Warnings should only be given for repeat behavior or serious offenses (IE: Sourcing. Sourcing happens fairly often, not direct links, but simple &quot;Where can I get X&quot;, &quot;Does anyone know a good vendor for X&quot; kind of stuff. Verbal warnings suffice most of the time.<br /> <br /> === Notify ===<br /> <br /> Syntax: ~notify &lt;room&gt; &lt;message&gt;<br /> <br /> *Available to all users. Send ~notify #tripsit for every encounter on #tripsit. Send notifications to #teamtripsit for all other reasons. Excellent communication tool. Use this as much as you'd like. Be sure to include the user's info, a short summary of the encounter, and anyone who assisted (tag them with @. e.g. ~notify #tripsit Trainwreck came into #tripsit and was really high on marijuana and lost the remote. @Teknos and I helped him find it. <br /> <br /> === Quiet ===<br /> <br /> Syntax: ~quiet (minutes) (#channel) &lt;user&gt; reason (Minutes and channel are optional)<br /> <br /> *Available to PowerUsers and higher. This prevents the user from speaking in that channel, as well as changing their nickname and also sends a notify to staff in that channel. Excellent for trolls and rowdy users.<br /> <br /> === Network Ban ===<br /> <br /> Syntax: ~nban &lt;user&gt; &lt;reason&gt;<br /> <br /> *Available to Mods and higher. Bans a user from all of our public channels. Infinitaly easier than playing whack-a-user when they pop into different channels. <br /> <br /> == Staff Expectations ==<br /> <br /> === Communication ===<br /> <br /> Communication is extremely important and as such we have several forms of contact for our team members.<br /> <br /> ==== IRC Communication ====<br /> <br /> Our main mode of communication is IRC as it allows real time converstations.<br /> <br /> ==== Staff Channels ====<br /> <br /> Required: All staff members should be on at least these channels.<br /> <br /> ===== #tripsit =====<br /> <br /> Our flagship channel for immediate assistance. Please idle here and if you see someone ping you with the !tripsit or ~tripsit command do your best to respond. Remember: KIPP! (Keep it positive people!)<br /> <br /> ===== #drugs: =====<br /> <br /> Tripsit handles moderation of this general talk channel.<br /> <br /> ===== #tripsitvip =====<br /> <br /> VIP section for regular #drugs users.<br /> <br /> *You need to be a registered user in order to join.<br /> <br /> ===== #tripsit.me =====<br /> <br /> Accessible to Power Users, Mods, and Admins only. Tripsitters and any user may join to discuss channel issues directly with mods but cannot idle.<br /> <br /> *Admin talk for issues with TripSit. <br /> <br /> *NO SOCIAL TALK PLEASE (take it to #teamtripsit or #tripsitvip), it makes reading the log a PITA when there's pages of irrelevant info.<br /> <br /> ===== #teamtripsit =====<br /> <br /> This is a channel for all staff. People who regular this room will recieve general tripsit memos regarding the network. Used for general and social chat, as well as teambuilding and brainstorming on how to improve the network<br /> <br /> *Optional: These rooms are affiliated with tripsit but are not the main rooms. <br /> <br /> ===== #psychonaut =====<br /> <br /> Channel for psychonaut discussion. Moderate the same way as you would for #drugs.<br /> <br /> ===== #psychopharm =====<br /> Channel to discuss pharmacology, chemistry, and other psychonautic topics.<br /> <br /> ===== #bitcoin =====<br /> <br /> Channel to discuss the online currency, bitcoin.<br /> <br /> ===== #tripradio =====<br /> <br /> [www.tripsit.fm]'s channel. Used for requests, music talk, DJ talk, and any other questions about becoming a DJ or getting involved with www.tripsit.fm.<br /> <br /> ==== Titanpad ====<br /> <br /> We document changes to the network in monthly pads. Please check the month and go to the corresponding pad. <br /> <br /> *Only staff members have access to the Titanpad by default. <br /> <br /> *When using the Titanpad, PLEASE ENTER YOUR NAME TO THE RIGHT SO WE KNOW WHO'S EDITING!<br /> <br /> *When making a new pad, please be sure to include a title and classification (user, info, misc., etc)<br /> <br /> *Only make a pad password protected if you have consulted with one of the admins about the contents of the pad. Admins have access to password protected pads.<br /> <br /> ==== Nexus Forum ====<br /> <br /> Nexus forum topics are used for discussion and votes. Please keep up to date with the Administrator section on the Nexus forums. This is where we will have the majority of our meetings, discussion about policy changes, etc. Click LIKE to notify that you have read a thread or a reply. If you cannot get access to the Administrator forums, please contact a Nexus admin (Teknos, reality, trees).<br /> <br /> ==== Emails ====<br /> <br /> If you would like a @tripsit.me email please let an admin know.<br /> <br /> == Network Wide Duties and Job Functions ==<br /> <br /> ===General Attitude===<br /> <br /> Staff members are positive, nice, respectful and professional in their dealings with members whether regular or staff; they represent the entire network! We want people who have leadership skills and can enforce rules whilte still promoteing a positive environment. They guide conversation to an acceptable level of quality by being positive and supportive at all times.while maintaining a positive and compassionate attitude.<br /> <br /> We want all of our staff members to be role models and regular contributors. All staff supervise and advance part of the TripSit network. We expect them to be able to devote a reasonable amount of time to TripSit projects, including: Nexus, Wiki, a TripSit affiliated IRC channel, the Official TinyChat, twitter, and future TripSit projects. Contribute Contribute Contribute! We want you on the team! We want your input!<br /> <br /> ===Enforce Rules===<br /> <br /> You will be expected to know the network policies and procedures as listed at http://wiki.tripsit.me/wiki/IRC_rules. Our staff will recognize misinformation, request citations when needed, and deal with trolls. Remember: No info &gt; bad info.<br /> <br /> === Ban-Appealment Policy ===<br /> <br /> It is network policy not to discuss a ban in PM. If a user wishes to contest a ban ask them to join #tripsit.me to appeal.<br /> <br /> === Populate other channels ===<br /> <br /> Move conversations to appropriate channels: IE: #psychonaut for spiritual talk, #psychopharm for chemistry discussion, #tripsitvip for slower, denser chat and the Nexus blogs for trip reports.<br /> <br /> === Be Involved ===<br /> <br /> Try to get involved with the various other TripSit projects. Get a Nexus account, learn to DJ, contribute to the Wiki. Contribute Contribute Contribute! We want you on the team! We want your input!<br /> <br /> == Tripsitter Duties ==<br /> <br /> Tripsitters are the backbone of our network. Without their selfless efforts we would not be here today. Each of us have stepped up in the #tripsit room to help people and it's a rite of passage to advance to other positions in the network. As such we have fairly high expectations of our tripsitters and expect the best out of them. <br /> <br /> You will continue to be an active, responsible trip sitter in the #tripsit channel. After recieving the proper flags, you will recieve !tripsit and ~tripsit notifications and are expected to respond to them whenever possible. You may tell tripbot ~gettripsitentries and he will let you know when new users enter #tripsit and may need help. Please respond to anyone joining #tripsit with a &quot;how are you doing&quot; or something to that effect. If the user does not need help and just wants general chat, direct them to /join #drugs. If the user needs help, do the best you can to answer their questions while keeping in mind no info is always better than false info. Never be afraid to defer a question to another member of the team by asking in #teamtripsit or even to use the '~tripsit user' command yourself to let people know a user needs further help. When the encounter is over you must send a notify to tripbot (syntax below) detailing how it went. You must send an notify for EACH and EVERY encounter. There is a no tollerance policy for trolling and sarcasm, you're free to ~report &lt;user&gt; whenever you feel they cross the line.<br /> <br /> If a user is trolling, becoming overly aggressive, or otherwise causing a problem, you may ~quiet (syntax below) them.<br /> <br /> == PowerUser Responsibilities==<br /> <br /> Summing up the responsibilities of a Power User would be the word &quot;guidance.&quot; <br /> <br /> *They represent our network and make sure that things are going smoothly. <br /> <br /> *They don't have the responsiblity of kick/baning people and their primary goal is to be helpful and positive. <br /> <br /> *They multitask by guiding all tripsit channels into a positive light. <br /> <br /> *They make heavy use of the ~report command for notification of our team. <br /> <br /> *PowerUsers cannot kick or ban, so please ~warn the offender, ~report them, and ~quiet if necessary, and if an admin is not online initiate a !voteban<br /> <br /> == Moderator Responsibilities ==<br /> <br /> Moderators have leadership skills and can enforce rules while maintaining a positive and compassionate attitude. They assume all the roles and responsibilities of being a power user, but with additional powers and expectations for rule breakers, as discussed in the Rule Breaking Procedure. Physical, trees, toasterlizard, sundown and borax are moderators.<br /> <br /> == Admin Responsibilities ==<br /> <br /> Oversee entire TripSit Network and make sure the network doesnt burn down. Follow through on reports, log bans/warnings. Work on and delegate numerous projects relating to Nexus, Merch, Wiki, IRC, and other content. Work on IRL applications to our TripSit network, including merch, marketing, improving network<br /> <br /> == Rule Breaking Procedure ==<br /> <br /> === As a member ===<br /> <br /> *~report the user<br /> <br /> *If no action is taken, initiate a !votekick &lt;user&gt; yes/no or a !voteban<br /> <br /> === As a tripsitter ===<br /> <br /> * ~report &lt;user&gt; and discuss the problem with other staff in #teamtripsit.<br /> * ~quiet &lt;time&gt; &lt;#channel&gt; &lt;username&gt; &lt;reason&gt; to quiet problematic users.<br /> <br /> === As a Power User ===<br /> <br /> *Follow the above procedure and respond to ~reports by telling the TripSit team via ~notify #channel that you recieved the report and will talk to the person in PM. Warning will be sent via PM on most occasions as to avoid drama in the main channels and a note will be added to their file on Titanpad. Occasionally public warnings will be issued. If action continues then you may issue an official ~warning to them. If they persist without a moderator stepping in, you may ~quiet them. <br /> <br /> * ~report #channel user reason' every time you have to verbally warn a user. Instances of ~quiet etc are automatically documented (and you can provide a reason along with them).<br /> <br /> === As a moderator: ===<br /> <br /> *You have the power to kick/ban people from the network. We ask that you use the corresponding Tripbot commands for this. Your involvement starts when the powerusers' end. After a ~report and/or ~warning has been issued, you may ~kick the user as a final warning. Always provide a reason for the kick. <br /> <br /> *Finally, if they continue their behavior, you may ~nban them from the network. Remember that banned users don't give good reviews or come back to help so do this as a last resort. Admins/mods will investigate every ban so make sure that you feel the ban is necessary. <br /> <br /> **Remember to keep logs and documentation on Titanpad. <br /> <br /> **If they protest or are unclear as to why they are banned, do not argue in PM, invite them to #tripsit.me to keep it public and explain why they were banned. <br /> <br /> **Keep it professional; do not make it personal, seek vengeance or retaliation. &quot;Please do not take any of this personally as we are running a professional harm reduction network. We love you all, but some of you need a break sometimes!&quot;<br /> <br /> == Default Nicknames ==<br /> <br /> Sometimes a user will come in with a default nickname. Different nicknames indicate where they came from.<br /> <br /> *Social = #drugs<br /> <br /> *Druggiter= #drugs<br /> <br /> *Psychonaut = #psychonaut<br /> <br /> *Pharmer = #psychopharm<br /> <br /> Should be greeted upon entry, this isn't always possible, considering the volume of people that join #tripsit. Do your best to be welcoming though!<br /> <br /> *TripDude = #tripsit (Non immediate assistance)<br /> <br /> *TripsitMe = #tripsit (Immediate assistance link)<br /> <br /> *Sapling = #tripsit (Immediate assistance link)<br /> <br /> == Applications and new staff ==<br /> <br /> We do not need a certain number of staff, but it would be foolish to turn down someone who wants to help. If you or someone you know wants to work on a project let the POC of that branch know and fill out an application: http://wiki.tripsit.me/wiki/Application</div>

Denniskombucha https://wiki.tripsit.me/index.php?title=User:Jane/Tinychat&diff=1769 2013-12-08T18:27:59Z

<p>Denniskombucha: /* episode iv: a new hope */</p> <hr /> <div>== episode iv: a new hope ==<br /> # dbad<br /> # audio consent, default no-mike, music okay &lt;nowiki&gt;[+consent]&lt;/nowiki&gt;<br /> # tripsit rules, in full, apply. if you aren't allowed to do it there, don't do it here.</div>

Denniskombucha