3-MeO-PCP

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3-MeO-PCP in a pill form
3-MeO-PCP in a pill form

3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative anesthetic drug that is sold online as a research chemical. The effects are often described as being more euphoric and mentally clearer than many related compounds.

History

A 1965 article published by Maddox described the synthesis of 2-MeO-PCP and 4-MeO-PCP. Preparation of 3-MeO-PCP was described later in 1979 by Geneste et al.

The compound was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine derivatives. The activity of 3-MeO-PCP in man was not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency.

Dosage

3-MeO-PCP, like PCP is active in the single milligram range and therefor can be hard to accurately measure.

Most if not all consumer-grade jewelry-scales advertised as working at the 0.001g (mg) range are not reliably accurate enough to measure quantities weighing less than around 15-25 mg depending on the model and calibration. With a drug as potent as 3-MeO-PCP a small discrepancy in measurement can make a world of difference in physical and mental response to the dose. It is for these reasons that it would be in one's best interest to use a volumetric dose measurement technique as outlined in this guide.

Oral
Threshold 1.5-3 mg
Light 3-5 mg
Common 5-10 mg
Strong 10-15 mg
Heavy 15-18 mg+
Insufflated
Threshold 1-2 mg
Light 2-5 mg
Common 5-8 mg
Strong 8-12 mg
Heavy 12-15 mg+

Duration

Oral
Onset 20-40 minutes
Total 3-5 hours +/- 60 minutes, dependent on dose.
After-effects 2-48 hours
Insufflated
Onset 10-30 minutes
Total 2-4 hours +/- ~30 minutes, dependent on dose.
After-effects 2-48 hours

Effects

Positive

  • Increase in energy / stimulation
  • Euphoria
  • Pleasant mental and/or body high
  • Music appreciation
  • Disconnected thoughts
  • Sense of calm
  • Increased sociability, loss of inhibitions
  • Closed and open-eye visuals
  • Shifts in perception of reality

Neutral

  • Increased heart rate (lower doses)
  • Altered time perception
  • Disrupted speech patterns
  • Analgesia (decreased pain awareness) and numbness
  • Distorted sensory perceptions, hallucinations
  • Unusual and unpredictable behavior
  • Mild to moderate dissociation
  • Confusion, disorientation

Negative

  • Disturbing hallucinations and/or delusions
  • Anxiety, paranoia
  • Severe dissociation, depersonalization
  • Ataxia (loss of motor coordination)
  • Psychotic episodes
  • Nausea, vomiting
  • Temporary amnesia
  • Severe distortion or loss of auditory/visual perception

Harm Reduction

  • 3-Meo-PCP is a very powerful NMDA antagonist (doses are on par with PCP), and as such it has the potential to be very confusing.
  • 3-MeO-PCP is considered to be a 'research-chemical', simply meaning that there is little to no clinical data on long-term effects.
  • 3-MeO-PCP, as with all arylcyclohexylamine class dissociative compounds may cause neurotoxicity when used frequently or in high dose.
  • 3-MeO-PCP acts as a mild Serotonin Reuptake Inhibitor and as such may risk adverse effects as a result of synergy when used with certain serotogenic drugs or medications. See Interactions.
  • It is difficult to measure 3-MeO-PCP accurately with a scale because it is active in the 1-10 mg range. See the dosage section for more information.
  • 3-MeO-PCP has a steep dose-response-curve and an onset ranging from approximately 20-40 minutes. It is inadvisable to redose, especially within the first hour.

For more information see Dissociative Harm-Reduction.

Interactions

Check out our Drug Combinations page and chart for interactions and combinations of common drugs. PCP and 3-MeO-PCP have similar profiles and as such its safe to assume the PCP combination-chart data also applies to 3-MeO-PCP.

Specifically, do not mix 3-MeO-PCP with alcohol or benzodiazepines. 3-MeO-PCP will also likely produce synergistic effects if used in conjunction with certain serotogenic medications or drugs.

Chemistry and Pharmacology

3-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP. It is also a Serotonin Reuptake Inhibitor (SRI).

3-MeO-PCP hydrochloride is a white crystalline solid with a melting point of 204-205°C.

3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter and 42 for the sigma1 receptor.

Legal status

UK: Class B, as are all arylcyclohexamines.

US: Covered by the analogue act if sold for human consumption.

Links

Wikipedia

Interview with a Ketamine Chemist

From MXE to PCP