General Information

Zolpidem, brand name Ambien, Stilnox is a Z-drug prescribed by doctors to help patients sleep. Zolpidem has very weak anxiolytic, myorelaxant, and anticonvulsant properties but very strong hypnotic properties. In low doses and without mixing, zolpidem is great for people who have trouble sleeping. In high doses, you may black out and do very dangerous/risky things and not remember it. Zolpidem is not a recreational drug and should be used only as prescribed.


The United States patent for zolpidem was held by the French pharmaceutical corporation Sanofi-Aventis. On April 23, 2007, the U.S. Food and Drug Administration (FDA) approved 13 generic versions of zolpidem tartrate. Zolpidem is available from several generic manufacturers in the UK, as a generic from Sandoz in South Africa and TEVA in Israel, as well as from other manufacturers such as Ratiopharm and Takeda GmbH (both German).



Light: 10mg

Common: 20-30mg

Strong: 40-50mg

Heavy: 50mg NOTE: Any more and you risk blacking out and becoming a ambien "walrus", unable to function well physically and mentally.



Onset: 15-30 min

Peak: 90min

Total Duration: 8-10 hours. Half life 2-3 hours

After-effects: Drowsiness, physically and mentally tired. Look below for potential negative side effects


Some users have reported unexplained sleepwalking while using zolpidem, as well as sleep driving, binge eating while asleep, and performing other daily tasks while sleeping.


  • Helps with insomnia/sleep
  • Euphoria and/or dysphoria


  • Hallucinations, through all physical senses, of varying intensity
  • Increased appetite
  • Increased or decreased libido
  • Uninhibited extroversion in social or interpersonal settings


  • Headaches (mostly withdrawal symptom)
  • Nausea (mostly withdrawal symptom)
  • Vomiting (mostly withdrawal symptom)
  • Dizziness
  • Anterograde amnesia
  • Delusions
  • Altered thought patterns
  • AtaxiaLoss of motor coordination or poor motor coordination, difficulty maintaining balance
  • Increased impulsivity (mostly withdrawal symptom)
  • When stopped, rebound insomnia may occur
  • Impaired judgment and reasoning

Harm Reduction

General info and things to avoid.

  • Do not exceed your prescribed dose.
  • Do not drive or opporate heavy machinery
  • Its best to just go to bed


An overdose of zolpidem may cause excessive sedation, pin-point pupils, or depressed respiratory function, which may progress to coma, and possibly death. Combined with alcohol, opiates, or other CNSCentral Nervous System depressants, it may be even more likely to lead to fatal overdoses. Zolpidem overdosage can be treated with the benzodiazepine receptor antagonistA substance that interferes with or inhibits the physiological action of another. flumazenil, which displaces zolpidem from its binding site on the benzodiazepine receptor to rapidly reverse the effects of the zolpidem.


Chronic users of high doses are more likely to develop physical dependence on the drug, which may cause severe withdrawal symptoms, including seizures, if abrupt withdrawal from zolpidem occurs.


  • Benzodiazapines
  • Alcohol
  • Opiates
  • Other CNSCentral Nervous System depressants


Notable drug-drug interactions with the pharmacokinetics of zolpidem include chlorpromazine, fluconazole, imipramine, itraconazole,ketoconazole, rifampicin, and ritonavir. Interactions with carbamazepine and phenytoin can be expected based on their metabolic pathways, but have not yet been studied.

Chemistry and Pharmacology

Zolpidem is a short-acting nonbenzodiazepine hypnotic that potentiates GABAGamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter., an inhibitory neurotransmitter, by binding to GABAA receptors at the same location as benzodiazepines.

Legal status

  • US: Schedule IV controlled substance in the U.S., according to the Controlled Substances Act, given its potential for abuse and dependence.


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