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Agarin, 5-(aminomethyl)-3- [2H] -isoxazolone, pyroibotenic
Substance type: amino acid, isoxazole derivative
Muscimol was first described in 1964 as a constituent
of Amanita pantherina. Muscimol is the
decarboxylated product of ibotenic acid and is
considered to be more psychoactive than it. Some
15 to 20 mg is regarded as a psychoactive dosage
(Muller and Eugster 1965; Ott 1993,446*; Scotti et
Muscimol is an analog of the neurotransmitter
GABAGamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter. (gamma amino butyric acid) and docks to
its receptor (Johnston 1971). Kavapyrones (cf.
Piper methysticum) also bind to the same receptor.
Ibotenic acid as well as muscimol were detected
in the urine of people who had eaten fly agaric
mushrooms (Amanita muscaria) about an hour
earlier. An experiment with mice conducted by the
same team of researchers found that the amount of
active constituents in the urine passed by one
inebriated animal was not sufficient to inebriateanother animal (Ott et al. 1975).
|Commercial Forms and Regulations
Muscimol can be purchased from chemical suppliers.
The substance is legal and is not subject to
any specific regulations.
See also the entries for Amanita muscaria and
Johnston, G. A. R. 1971. Muscimol and the uptake of
,),-aminobutyric acid by rat brain slices.
Muller, G. F. R., and C. H. Eugster. 1965. Muscimol,
ein pharmakodynamisch wirksamer Stoff aus
Amanita muscaria. Helvetica Chemica Acta
Ott, Jonathan, Preston S. Wheaton, and William
Scott Chilton. 1975. Fate of muscimol in the
mouse. Physiol. Chem. and Physics 7:381-84.
Scotti de Carolis, A., et al. 1969.
Neuropharmacological investigations on
muscimol, a psychotropic drug extracted from
Amanita muscaria. Psychopharmacologia15:186-95.