|
|
| (3 intermediate revisions by 3 users not shown) |
| Line 1: |
Line 1: |
| | | [[Category:Drugs]] |
| <table style="font-family: Arial, Helvetica, sans-serif; font-size: 9pt;" width="100%" border="0" cellspacing="0" cellpadding="0">
| | [[Category:Psychedelic]] |
| | | [[Category:Chemicals]] |
| <tr>
| |
| <td valign="top" width="50%"><strong>Other Names</strong>
| |
| | |
| Agarin, 5-(aminomethyl)-3- [2H] -isoxazolone, pyroibotenic
| |
| | |
| acid, 3-hydroxy-5-aminomethyl-isoxazole
| |
| | |
| Substance type: amino acid, isoxazole derivative
| |
| | |
| Muscimol was first described in 1964 as a constituent
| |
| | |
| of Amanita pantherina. Muscimol is the
| |
| | |
| decarboxylated product of ibotenic acid and is
| |
| | |
| considered to be more psychoactive than it. Some
| |
| | |
| 15 to 20 mg is regarded as a psychoactive dosage
| |
| | |
| (Muller and Eugster 1965; Ott 1993,446*; Scotti et
| |
| | |
| al. 1969).
| |
| | |
| Muscimol is an analog of the neurotransmitter
| |
| | |
| GABA (gamma amino butyric acid) and docks to
| |
| | |
| its receptor (Johnston 1971). Kavapyrones (cf.
| |
| | |
| Piper methysticum) also bind to the same receptor.
| |
| | |
| Ibotenic acid as well as muscimol were detected
| |
| | |
| in the urine of people who had eaten fly agaric
| |
| | |
| mushrooms (Amanita muscaria) about an hour
| |
| | |
| earlier. An experiment with mice conducted by the
| |
| | |
| same team of researchers found that the amount of
| |
| | |
| active constituents in the urine passed by one
| |
| | |
| inebriated animal was not sufficient to inebriate
| |
| | |
| another animal (Ott et al. 1975).</td>
| |
| <td valign="top" width="53%"><strong>Commercial Forms and Regulations
| |
| | |
| </strong>Muscimol can be purchased from chemical suppliers.
| |
| | |
| The substance is legal and is not subject to
| |
| | |
| any specific regulations.
| |
| | |
| <strong>
| |
| | |
| Literature</strong>
| |
| | |
| See also the entries for Amanita muscaria and
| |
| | |
| ibotenic acid.
| |
| | |
| Johnston, G. A. R. 1971. Muscimol and the uptake of
| |
| | |
| ,),-aminobutyric acid by rat brain slices.
| |
| | |
| Psychopharmacologia 22:230.
| |
| | |
| Muller, G. F. R., and C. H. Eugster. 1965. Muscimol,
| |
| | |
| ein pharmakodynamisch wirksamer Stoff aus
| |
| | |
| Amanita muscaria. Helvetica Chemica Acta
| |
| | |
| 48:910-26.
| |
| | |
| Ott, Jonathan, Preston S. Wheaton, and William
| |
| | |
| Scott Chilton. 1975. Fate of muscimol in the
| |
| | |
| mouse. Physiol. Chem. and Physics 7:381-84.
| |
| | |
| Scotti de Carolis, A., et al. 1969.
| |
| | |
| Neuropharmacological investigations on
| |
| | |
| muscimol, a psychotropic drug extracted from
| |
| | |
| Amanita muscaria. Psychopharmacologia
| |
| | |
| 15:186-95.</td>
| |
| </tr>
| |
| | |
| </table>
| |