(Created page with " <table style="font-family: Arial, Helvetica, sans-serif; font-size: 9pt;" width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td valign="top" width="50%"><strong>...")
 
 
(3 intermediate revisions by 3 users not shown)
Line 1: Line 1:
 
+
[[Category:Drugs]]
<table style="font-family: Arial, Helvetica, sans-serif; font-size: 9pt;" width="100%" border="0" cellspacing="0" cellpadding="0">
+
[[Category:Psychedelic]]
 
+
[[Category:Chemicals]]
<tr>
+
<td valign="top" width="50%"><strong>Other Names</strong>
+
 
+
Agarin, 5-(aminomethyl)-3- [2H] -isoxazolone, pyroibotenic
+
 
+
acid, 3-hydroxy-5-aminomethyl-isoxazole
+
 
+
Substance type: amino acid, isoxazole derivative
+
 
+
Muscimol was first described in 1964 as a constituent
+
 
+
of Amanita pantherina. Muscimol is the
+
 
+
decarboxylated product of ibotenic acid and is
+
 
+
considered to be more psychoactive than it. Some
+
 
+
15 to 20 mg is regarded as a psychoactive dosage
+
 
+
(Muller and Eugster 1965; Ott 1993,446*; Scotti et
+
 
+
al. 1969).
+
 
+
Muscimol is an analog of the neurotransmitter
+
 
+
GABA (gamma amino butyric acid) and docks to
+
 
+
its receptor (Johnston 1971). Kavapyrones (cf.
+
 
+
Piper methysticum) also bind to the same receptor.
+
 
+
Ibotenic acid as well as muscimol were detected
+
 
+
in the urine of people who had eaten fly agaric
+
 
+
mushrooms (Amanita muscaria) about an hour
+
 
+
earlier. An experiment with mice conducted by the
+
 
+
same team of researchers found that the amount of
+
 
+
active constituents in the urine passed by one
+
 
+
inebriated animal was not sufficient to inebriate
+
 
+
another animal (Ott et al. 1975).</td>
+
<td valign="top" width="53%"><strong>Commercial Forms and Regulations
+
 
+
</strong>Muscimol can be purchased from chemical suppliers.
+
 
+
The substance is legal and is not subject to
+
 
+
any specific regulations.
+
 
+
<strong>
+
 
+
Literature</strong>
+
 
+
See also the entries for Amanita muscaria and
+
 
+
ibotenic acid.
+
 
+
Johnston, G. A. R. 1971. Muscimol and the uptake of
+
 
+
,),-aminobutyric acid by rat brain slices.
+
 
+
Psychopharmacologia 22:230.
+
 
+
Muller, G. F. R., and C. H. Eugster. 1965. Muscimol,
+
 
+
ein pharmakodynamisch wirksamer Stoff aus
+
 
+
Amanita muscaria. Helvetica Chemica Acta
+
 
+
48:910-26.
+
 
+
Ott, Jonathan, Preston S. Wheaton, and William
+
 
+
Scott Chilton. 1975. Fate of muscimol in the
+
 
+
mouse. Physiol. Chem. and Physics 7:381-84.
+
 
+
Scotti de Carolis, A., et al. 1969.
+
 
+
Neuropharmacological investigations on
+
 
+
muscimol, a psychotropic drug extracted from
+
 
+
Amanita muscaria. Psychopharmacologia
+
 
+
15:186-95.</td>
+
</tr>
+
 
+
</table>
+

Latest revision as of 10:50, 11 March 2015

Top Contributors