Mephedrone (4-Methylmethcathinone, 4-MMC, and also known by slang terms such as 'meow' and 'M-CAT') is a synthetic stimulant with empathogenic effects. A research chemical first developed as an analogue of MDMA in 1929, it eventually became popular among recreational drug users between 2007 and 2009 as it became available for purchase online. As a result, it was used increasingly in Europe, Australia, and New Zealand, associated with several deaths, and as a result was controlled in some countries.
Because of the similarity in names, it is sometimes confused with Methedrone (4-Methoxymethcathinone, βk-PMMC) or Methylone (βk-MDMA).
Duration may lengthen with higher doses.
|| 15-45 minutes
|| 15-30 minutes
|| 2-5 hours
|| 2-4 hours
|| 5-15 minutes
|| 15-30 minutes
|| 1-3 hours
|| 2-4 hours
Generally described as being more intense of a stimulant than MDMA, providing greater euphoria, but with somewhat less of an empathogenic feel and a shorter length to the 'rush.'
It is often reported as very 'fiendish,' with the tendency to cause users to redose repeatedly throughout the experience.
- Mental and physical stimulation
- Feelings of empathy, openness
- Increase in sociability, desire to talk with others
- General change in consciousness (as with most psychoactives)
- Unusual body sensations (facial flushing, chills, goosebumps, body energy)
- Change in body temperature regulation
- Increase in heart rate and blood pressure
Likelihood of negative side effects increases with higher doses
- Strong desire to redose, craving to recapture initial euphoric rush
- Uncomfortable changes in body temperature (sweating/chills)
- Heart palpitations, sense of racing heart
- Impaired short term memory
- Tightened jaw muscles, grinding teeth (trismus and bruxia)
- Dizziness, light headedness, vertigo
- When insufflated: pain and swelling in nose and throat, sinusitis
- Taking Mephedrone while on SSRIs or MAOIs can cause serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. syndrome, which can be deadly.
- The drug has not been proven as neurotoxic, however primary indications show that it may well be. As this is the case, care should be taken to space experiences with this drug out - two weeks has been regarded as a good rule of thumb.
- Given the tendency for users to redose, issues such as malnutrition and sleep deprivation may become a problem with extended use. Try to sleep, and see Quick Guide to Stimulant Comedowns for more information on managing a comedown.
Chemistry and Pharmacology
Mephedrone is a releasing agent and reuptake inhibitor of dopamineA neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system., serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. and norepinephrine.
For a breakdown of the legal status of Mephedrone click here.