General Information

GHB (Gamma-Hydroxybutyric Acid) is a CNSCentral Nervous System depressant used as intoxicant. It is a naturally occurring substance found in the human central nervous system, as well as in wine, beef, small citrus fruits, and in small amounts in almost all animals. GHB has been used in a medical setting as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.

History

GHB was synthesized and introduced into medicine in 1960 and in 1963 discovered as a naturally occurring chemical in the human brain.

Dosage

Oral

Duration: 1-3 hours

Light: 0.5-1.5g

Common: 1-2.5g

Strong: 2-4g

GBL dose: 1ml GBL is equal to 1.6g GHB

Effects

Positive

  • Relaxation
  • Increased sociability
  • Positive mood changes
  • Euphoria
  • Empatogenic
  • Enhanced sensuality

Neutral

  • Dizziness

Negative

  • Nausea
  • Restlessness
  • Unconsciousness
  • Amnesia

After effects

  • Hangover (usually only occurs from high doses)
  • Sleepiness
  • Drowsiness

Harm Reduction

The only way to know the concentration of liquid GHB is to know and trust information provided by the source. Users should be extremely careful about GHB dosages as even small overdoses can result in temporarily unrousable sleep.

  • Avoid driving and operating heavy machinery
  • Don't mix it with Alcohol, or only very carefully
    • In humans, GHB has been shown to inhibit the elimination rate of alcohol. This may explain the respiratory arrest that has been reported after ingestion of both drugs.[30] A review of the details of 194 deaths attributed to or related to GHB over a ten-year period found that most were from respiratory depression caused by interaction with alcohol or other drugs
  • Recommended time (pauses) between using the substance:
    • 2-3 times a week should be the maximum
  • High Addiction potential


Chemistry and Pharmacology

GHB has at least two distinct binding sites in the central nervous system. GHB is an agonistA substance that initiates a physiological response when combined with a receptor. at the newly characterized GHB receptor, which is excitatory, and it is a weak agonistA substance that initiates a physiological response when combined with a receptor. at the GABAGamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter.-B receptor, which is inhibitory. GHB is a naturally occurring substance that acts in a similar fashion to some neurotransmitters in the mammalian brain. GHB is probably synthesized from GABAGamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter. in GABAergic neurons, and released when the neurons fire.

If taken orallyRoute of administration in which the subject swallows a substance., GABAGamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter. itself does not effectively cross the blood-brain-barrier.

Production

Production of GHB consists simply of mixing "lactone" (short for gamma butyrlactone) and lye (sodium hydroxide) in the proper amounts. It can also be converted from GBL.

Legal status

GHB is illegal in most parts of the world, GBL is legal in parts of Europe.

Links

http://en.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid

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