Sealed vial of etizolam solved in propylene glycol.

Etizolam is a research chemical analogue of the benzodiazepine class of drugs - the benzene ring being replaced by a thiophene ring, making it a thienodiazepineClose analogues of benzodiazepines.. The drug largely shares the effect profile of benzodiazepine drugs (being both hypnotic and anxiolytic), however studies have shown some major differences between etizolam and the more traditional benzos used for treatments; it suffers much less from the build-up of tolerance, and also has a larger range of observed side-effects with abuse.

History

The availability of Etizolam in the more general research chemical scene began around 2011, and attention has only increased since. Its prevalence is probably due to both the low cost of the drug (with 500-1000 standard doses costing around £100, and is available in bulk powder form for even less), and the highly addictive nature it shares with benzodiazepines.

Though relatively new to the recreational research chemical scene, etizolam differs from most other research chemicals in that it is actually approved and actively prescribed as a medical treatment for anxiety in many countries around the world (such as India) under brand names such as Etilaam and Etizest. Its origins as a medical drug are actually very unclear, though medical papers citing its use in the treatment of anxiety are recorded as early as the 90s.

Doses

Oral
Light .5-1mg
Common 1-2mg
Strong 2-5mg
Heavy 5mg+

Duration

Note: Duration can be significantly longer with higher doses.

Oral
Onset 20-60 Minutes
Total 5-8 hours

Effects

Positive

  • Anti-Anxiety
  • Relaxation
  • A Sense of Well Being

Neutral

  • Appetite fluctuation
  • Drowsiness

Negative

  • Memory loss
  • Potential blackout
  • Rage
  • Loss of a % of Motor Skills
  • Headaches
  • Dizziness
  • Irritability
  • LethargyA lack of energy and enthusiasm.
  • Personality Changes
  • Aggression
  • Depression
  • Nausea
  • Social Deterioration (Long Term)
  • Emotional Clouding

Long Term Effects

  • The effects of long-term Etizolam, as with benzodiazepine use include drug dependence as well as the possibility of adverse effects on cognitive function, physical health, and mental health.
  • There are a number of side-effects associated with addiction to benzodiazepines such as depression and flu-like symptoms, though occurring in only a small amount of people.

Harm Reduction

  • When on high doses of the drug, users are likely to black out and potentially hurt themselves through misadventure. If you are taking a hypnotic dose, it is best to confine yourself to your bed.
  • Some users report Etizolam as given to compulsive redosing, especially when a user is 'blacked out.' To avoid this, keep doses low and take note of reduced inhibitons while under the influence.
  • In some users, particular with abuse Etizolam has been shown to cause blepharospasmInvoluntary eye twitching. (involuntary eye twitching).
  • In very rare cases, Etizolam has been responsible for skin lesions in abusers.

Interactions

As with other depressants, Etizolam should not be combined with any other CNSCentral Nervous System depressants (such as alcohol), at the risk of respiratory depression, which can lead to death.

See the Drug combinations chart for more information.

Chemistry and Pharmacology

Etizolam is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.5 hours. Etizolam acts as a full agonistA substance that initiates a physiological response when combined with a receptor. at the benzodiazepine receptor to produce its range of therapeutic and adverse effects.

In addition, etizolam, unlike most other benzodiazepines, has prolactogenic effects, leading to an increase in blood levels of prolactin, which is a protein that in humans is best known for its role in enabling female mammals to produce milk. Etizolam abuse can also cause lactation in males.

During a controlled clinical trial that compared the effectiveness of etizolam and several benzodiazepines for the treatment of generalized anxiety disorder, it was found that etizolam became more effective from 2 weeks to 4 weeks, which implies a type of reverse tolerance.

The LD50The dosage of a substance at which 50% of the exposed subjects does not survive. To estimate the LD50 for humans, tests are conducted on non-human subjects. of Etizolam is currently unknown.

Legal status

USA

Etizolam is not controlled in the USA, however it is a Schedule I drug in Arkansas and Mississippi.

UK

Not controlled as of October 2014.

Germany

Controlled since 2013.

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